Thyroidal Iodine Metabolism and Uterine-Ovarian Characteristics of Rats and Swine Treated with Methallibure or Its Metabolites

Tj, Archbold; Pw, Aschbacher; Je, Tilton

doi:10.2527/jas1973.36157x

Journal of Animal Science

1973

DOI: 10.2527/jas1973.36157x

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Thyroidal Iodine Metabolism and Uterine-Ovarian Characteristics of Rats and Swine Treated with Methallibure or Its Metabolites

Archbold Tj

Aschbacher Pw

Tilton Je

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1974

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“…The drug may also directly modify thyroidal function (Archibald, Aschbacher & Tilton, 1973) and/or diminish ovarian sensitivity to circulating hormones. Undernutrition delays puberty till the rat reaches a body weight of 90 to 100 g. Since methallibure-fed rats fail to show signs of puberty even after they reach adult body weights, these effects of the drug do not seem to depend on a retardation of growth rate which is related to nutrition.…”

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Methallibure, Delayed Puberty and the Pituitary-Hypothalamic Complex of Female Rats

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1974

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Methallibure prevents the onset of puberty and ovulation and inhibits pituitary gonadotrophic activity in 30-day-old rats (Walpole, 1968). The compound also reduces food intake (Benson & Zagni, 1965) and body weight in adult rats (Labhsetwar & Walpole, 1972). Restriction of food intake per se causes a deficiency in LH secretion in adult rats (Howland, 1971), but Labhsetwar & Walpole (1972) have shown that the reduction in pituitary and plasma LH produced by methallibure in adult spayed rats is not secondary to its effect on food intake. It is due, presumably, to a primary effect on the hypothalamohypophysial complex (Malven, 1971). In the present study, we explored the recurrence of delayed puberty in intact rats treated with methallibure (Ayerst).Twenty-eight-day-old female rats of Sprague-Dawley strain from the Charles River Company were housed under standard conditions of lighting (07.00 to 21.00 hours) and temperature (71 to 72\s=deg\F). One group, having free access to food, served as fully fed controls. The treatment group received methallibure (40 mg/kg/day in 0\ m=. \ 2 ml of 0\m=.\5% Tween 80) orally for 20 days beginning at 28 days of age. The food consumption of these rats was measured daily and the same amount offered on the following day to those in the pair-fed group. (On the first day of the experiment, rats in the pair-fed group received an unrestricted quantity of food.) All the animals were weighed daily. Rats in a fourth, untreated, group were killed at 28 days of age following blood collection, under ether anaesthesia, into heparinized syringes. Blood was taken similarly from the remaining animals on the day following the last day of methallibure feeding. The pair-fed and fully fed rats were killed between 11.00 and 13.00 hours in such a way as to obtain representative samples during pro-oestrus and dioestrus. Organs were cleaned, and weighed on a torsion balance. Follicles and CL were counted after pressing ovaries between two slides and examining them under a microscope.Plasma was stored frozen until assayed for LH, FSH and prolactin (Niswender Midgley, Monroe & Reichert, 1968) using NIH kits and the reference standards NIAMD-Rat-LH-1-3, Rat FSH-1-1 and Rat-Prolactin-1-1. The data were ana¬ lysed by t test. 105

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Methallibure, Delayed Puberty and the Pituitary-Hypothalamic Complex of Female Rats

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1974

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Thyroidal Iodine Metabolism and Uterine-Ovarian Characteristics of Rats and Swine Treated with Methallibure or Its Metabolites

Cited by 1 publication

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Methallibure, Delayed Puberty and the Pituitary-Hypothalamic Complex of Female Rats

Methallibure, Delayed Puberty and the Pituitary-Hypothalamic Complex of Female Rats

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