Thyroiditis

Pearce, Elizabeth N.; Farwell, Alan P.; Braverman, Lewis E.

doi:10.1056/nejmra021194

Cited by 852 publications

(678 citation statements)

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“…Subacute thyroiditis is also referred as giant cell granulomatous thyroiditis or De Quervain thyroiditis. 17 Disruption of thyroid follicles associated with multinucleated giant cells and histiocytic reaction are diagnostic characteristics for subacute thyroiditis, when they were examined in early hyperthyroid phase. There are two different points to distinguish IgG4 thyroiditis and subacute thyroiditis histopathologically.…”

Section: Discussionmentioning

confidence: 99%

“…The typical histological features of Hashimoto's thyroiditis include a lymphoplasmacytic infiltration, a germinal center formation, follicular destruction, a Hurthle cell change, and variable degrees of fibrosis. 16,17 The incidental findings of focal (nonspecific) lymphocytic thyroiditis in the tumorbearing thyroid tissue were excluded from this study. This study was approved by the Kuma Hospital Bioethical Committee.…”

Section: Case Selectionmentioning

confidence: 99%

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Distinct histopathological features of Hashimoto's thyroiditis with respect to IgG4-related disease

Zhou

Ozaki

et al. 2012

Modern Pathology

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A form of Hashimoto's thyroiditis with lymphoplasmacytic sclerosing changes and increased numbers of IgG4-positive plasma cells has recently been reported in the literature. These histopathological features suggest that this subtype of Hashimoto's thyroiditis may be closely related to IgG4-related disease. Therefore, this unique form of IgG4-related Hashimoto's thyroiditis, which is referred to as IgG4 thyroiditis, has its own clinical, serological, and sonographic features that are distinct from those associated with non-IgG4 thyroiditis. IgG4 thyroiditis shares similarities with the well-known fibrous variant of Hashimoto's thyroiditis; however, the detailed histopathological features of IgG4 thyroiditis have not been well established. Based on immunostaining results, 105 patients with Hashimoto's thyroiditis were divided into an IgG4 thyroiditis group (n ¼ 28) and a non-IgG4 thyroiditis group (n ¼ 77). As in our previous reports, IgG4 thyroiditis was associated with a patient population of a younger age, a lower female-to-male ratio, rapid progression, higher levels of thyroid autoantibodies, subclinical hypothyroidism, and diffuse sonographic echogenicity. Histopathologically, this group revealed severe lymphoplasmacytic infiltration, dense stromal fibrosis, marked follicular cell degeneration, numerous micro-follicles, and notable giant cell/histiocyte infiltration. Importantly, the IgG4-related group did not completely overlap with fibrous variant of Hashimoto's thyroiditis. Four cases (14%) in the IgG4 thyroiditis group presented only mild fibrosis in the stroma, whereas 29 cases (38%) in the non-IgG4 thyroiditis group met the diagnostic criteria for fibrous variant of Hashimoto's thyroiditis. Furthermore, we observed three patterns of stromal fibrosis in Hashimoto's thyroiditis: interfollicular fibrosis, interlobular fibrosis, and scar fibrosis. The IgG4 thyroiditis group was significantly associated with the presence of predominant interfollicular fibrosis. In conclusion, IgG4 Hashimoto's thyroiditis presents histopathological features quite distinct from its non-IgG4 counterpart.

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Section: Discussionmentioning

confidence: 99%

Section: Case Selectionmentioning

confidence: 99%

Distinct histopathological features of Hashimoto's thyroiditis with respect to IgG4-related disease

Zhou

Ozaki

et al. 2012

Modern Pathology

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“…Hashimoto's thyroiditis (HT) -chronic lymphocytic thyroiditis or autoimmune thyroiditis-is the most common autoimmune thyroid disease and the most common non-iatrogenic cause of hypothyroidism [1]. This condition was first described in 1912 by Hakaru Hashimoto, a Japanese surgeon and pathologist [2].…”

Section: Introductionmentioning

confidence: 99%

Hashimoto’s Thyroiditis And Cancer: A Review

Salti

2017

int arch med

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Background: No consensus exists on the association betweenHashimoto's thyroiditis (HT) and cancer. To resolve this controversy, this review aimed to evaluate the relationship between the two conditions. Methods:Using pub-med database, we searched studies relevant to the topic focusing on the association between HT and papillary thyroid cancer (PTC), as well as the association between HT and primary thyroid lymphoma (PTL).Findings: Both HT and PTC are common worldwide, and the two conditions may be closely related. However, the relationship remains controversial. Some studies found that PTC coexisted with HT 2.8-fold more frequently, with variable prevalence ranging from 0.5 to 30%. In contrast to surgical and pathological series that suggested a positive correlation between the two diseases and even a cause-and-effect relationship, the other studies evaluating fine-needle aspirate specimens did not find a statistically significant correlation. On the other hand, the relationship between PTL and HT appears well established. Conclusion:The existing data provide inconsistent evidence favoring a causal relationship between HT and PTC. Prospective studies are needed to further elucidate the relationship. However patients with HT are at risk for PTL. Therefore careful observation and follow-up of HT patients is recommended.

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“…16 Symptoms of HT include weight gain, depression, anxiety, sensitivity to cold, and chronic fatigue. 17 Diagnosis for HT is made by testing TSH, free T 4 , free T 3 , thyroid peroxidase antibodies (anti-TPO), and thyroglobulin antibodies (anti-TG). Diagnosis may be assisted by performing ultrasonography of the thyroid gland, where a mild goiter is sometimes present.…”

Section: Introductionmentioning

confidence: 99%

Chiropractic Management of a Patient With Chronic Fatigue: A Case Report

Arick

2016

Journal of Chiropractic Medicine

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Objective: The purpose of this case report was to describe the examination and management of a patient with chronic fatigue. Clinical Features: A 34-year-old woman presented to a chiropractic clinic with complaints of fatigue and inability to lose weight for 2 years. When tested, she was found to have high serum thyroglobulin antibodies, low serum vitamin D 3 , low saliva dehydroepiandrosterone-sulfate, and low saliva total and diurnal cortisol. Intervention and Outcome: The patient was placed on an anti-inflammatory ancestral diet and given recommendations to decrease the aerobic intensity of her exercise routine. On the basis of the result of conventional and functional laboratory tests, she was prescribed a treatment plan of targeted supplementation. After 12 weeks of application of dietary, lifestyle, and supplementation recommendations, the patient reported experiencing increased energy and weight loss of 15 pounds. Her thyroglobulin antibodies returned within reference range, salivary cortisol increased and closely followed the proper circadian rhythm, and dehydroepiandrosterone-sulfate increased. Conclusions: This report describes improvement in a patient with chronic fatigue with the use of nonpharmaceutical polytherapy involving dietary changes, lifestyle modification, and supplementation. (J Chiropr Med 2016;15:314-320)

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Thyroiditis

Cited by 852 publications

References 68 publications

Distinct histopathological features of Hashimoto's thyroiditis with respect to IgG4-related disease

Distinct histopathological features of Hashimoto's thyroiditis with respect to IgG4-related disease

Hashimoto’s Thyroiditis And Cancer: A Review

Chiropractic Management of a Patient With Chronic Fatigue: A Case Report

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