Thyrotoxicosis and Heart Disease

Summers, V. K.; Surtees, S. J.

doi:10.1111/j.0954-6820.1961.tb07877.x

Cited by 40 publications

(5 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The association of hyperthyroidism and cardiovascular changes has been well documented (6,8,9). Thyrotoxicosis can aggravate underlying heart problems and worsen the clinical manifestations, especially in the elderly.…”

Section: Discussionmentioning

confidence: 99%

Chylous Ascites as a Manifestation of Thyrotoxic Cardiomyopathy in a Patient with Untreated Graves' Disease

Hsieh

Chen

Wang

et al. 2010

Thyroid

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Chylous Ascites as a Manifestation of Thyrotoxic Cardiomyopathy in a Patient with Untreated Graves' Disease

Hsieh

Chen

Wang

et al. 2010

Thyroid

View full text Add to dashboard Cite

show abstract

“…The prevalence of thyrotoxic HF in patients with acute HF was less than that reported in the chronic HF population. Previous studies 27,28 observed that clinical hyperthyroidism was found in about 6–19% of outpatient patients with HF. The prevalence of thyrotoxic HF in patients hospitalized for acute HF has not been described.…”

Section: Discussionmentioning

confidence: 92%

Clinical phenotypes and prognosis of thyrotoxic heart failure and cardiomyopathy in patients hospitalized for acute heart failure

et al. 2021

View full text Add to dashboard Cite

Background We sought to examine clinical characteristics and outcomes in patients hospitalized for acute heart failure (HF) and thyrotoxicosis. Methods Patients with thyrotoxic HF were compared with age and gender-matched patients hospitalized for acute HF (controls). Thyr-HF was defined by the Framingham criteria for HF and clinical hyperthyroidism. Thyrotoxic cardiomyopathy was defined as left ventricular ejection fraction (LVEF) < 55%. Results Of 11 109 consecutive patients hospitalized for acute HF between 1 January 2002 and 1 January 2017, 92 patients (0.8%) had thyrotoxic HF. Clinical and echocardiographic data were available in 87 patients (age 51 ± 16 years; 74% female), representing the study population. Compared with controls, patients with Thyr-HF had a smaller body surface area (BSA), a higher LVEF, a lower LV end-diastolic diameter, a higher tricuspid annular plane systolic excursion (TAPSE), higher blood pressure, higher heart rate, and were more likely to have right-sided HF at presentation (P < 0.01 for all). The survival rate among patients with thyrotoxic HF was higher than the control group (HR: 4.3; 95% CI: 2.1-9.5). Fifty-eight percent of patients with thyrotoxic HF had thyrotoxic cardiomyopathy. In multivariate analysis, TAPSE (OR = 46; 95% CI: 1.04-2008.20; P = 0.047) and leukocytosis (OR = 16; 95% CI 1.01-259.39; P = 0.049) correlated with thyrotoxic cardiomyopathy. LV recovery was observed in 69% of these patients. Conclusions Thyrotoxic HF was uncommon among patients hospitalized for acute HF. However, after definitive therapy, these patients had a more favourable prognosis than those hospitalized for acute HF without thyrotoxic HF. Clinical phenotypes of thyrotoxic HF include small BSA, middle-aged female, HF-pEF, and right-sided HF. Thyrotoxic cardiomyopathy affected over half of the patients with thyrotoxic HF with a two-third recovery rate.

show abstract

“…Thyrotoxicosis can present with tachycardia, atrial fibrillation, cardiomyopathy, accelerated hypertension, and pulmonary edema. Congestive heart failure occurs in up to 6% of patients with thyrotoxicosis [ 17 ]. In most cases, the resulting heart disease is related to uncontrolled atrial fibrillation and prolonged significant tachycardia.…”

Section: Discussionmentioning

confidence: 99%

A Uniquely Challenging Case of Poorly Controlled Hyperthyroidism With a Coexisting Thyroglossal Cyst

Khalaf

Sarwani

Fardan

et al. 2021

Cureus

View full text Add to dashboard Cite

Hyperthyroidism is a common disease. Thyroglossal duct cysts are also a very common type of congenital anomalies. Their co-existence is, however, rare with only a few cases described in the literature of the same. We describe the case of a 44-year-old female who presented initially 16 years ago with hyperthyroid symptoms related to Graves’ disease diagnosed serologically and by thyroid scan and ultrasound. Incidentally, she was also noted to have a non-complicated thyroglossal duct cyst. She was initially started on anti-thyroid medications but remained in a hyperthyroid state throughout most of her illness. Radioiodine ablative therapy and surgical resection were delayed due to the patient’s dispreference. After a long period of missed follow up, she presented with a thyroid storm and underwent a total thyroidectomy and cyst resection. The key endocrine issues learned from this case include: 1) dealing with non-compliant patients in terms of poorly controlled hyperthyroidism and refusal to follow the recommended treatment, 2) observing the natural disease progression of untreated Graves’ disease coexisting with a thyroglossal duct cyst, and 3) describing a rare incidental finding of a thyroglossal duct cyst coexisting with Graves' disease in the absence of ectopic hormone production. A few cases have described hyperthyroidism related to remnants of thyroid tissue in the thyroglossal duct or related to the thyroid gland. To the best of our knowledge, there are no cases reported of Graves’ disease coexisting with a non-complicated thyroglossal duct cyst making our case unique and first of its kind.

show abstract

Thyrotoxicosis and Heart Disease

Cited by 40 publications

References 29 publications

Chylous Ascites as a Manifestation of Thyrotoxic Cardiomyopathy in a Patient with Untreated Graves' Disease

Chylous Ascites as a Manifestation of Thyrotoxic Cardiomyopathy in a Patient with Untreated Graves' Disease

Clinical phenotypes and prognosis of thyrotoxic heart failure and cardiomyopathy in patients hospitalized for acute heart failure

A Uniquely Challenging Case of Poorly Controlled Hyperthyroidism With a Coexisting Thyroglossal Cyst

Contact Info

Product

Resources

About