Thyrotoxicosis: Experience from the King Khalid University Hospital, Riyadh

Sulimani, Riad A.; Mekki, M.; Jayakumar, RV; Subesinghe, Nyanissara

doi:10.5144/0256-4947.1989.455

Cited by 7 publications

(2 citation statements)

References 10 publications

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“…It has been suggested that carcinogenic amines are substrates for N‐acetyltransferases. Similarly, the age of onset of thyrotoxicosis among Saudi patients is relatively younger when compared with Caucasian patients (33). Although the exact mechanism and significance of these associations still require further studies, it is prudent to exercise caution in Saudi population treated with INH and other similar drugs in order to avoid unwanted drug interaction.…”

Section: Discussionmentioning

confidence: 99%

Isoniazid acetylation phenotyping in Saudi Arabs

Matar

Mayet²,

Ayoola

et al. 2004

J Clin Pharm Ther

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Section: Discussionmentioning

confidence: 99%

Isoniazid acetylation phenotyping in Saudi Arabs

Matar

Mayet²,

Ayoola

et al. 2004

J Clin Pharm Ther

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“…The same low female:male ratio (1.7:1) was also reported by Sulimani. 10 The low female:male ratio may (partly) be due to a certain referral pattern. The apparently high frequency of small, firm, granular or nodular glands at palpation is also unusual.…”

Section: Discussionmentioning

confidence: 99%

High-Dose Iodine 131 Treatment of Hyperthyroidism: Experience at King Faisal Specialist Hospital and Research Centre

1988

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We have treated 186 Saudi patients (110 females, 76 males) with hyperthyroidism in the last 10 years. Case records of 100 patients were randomly selected for review. The female:male ratio was 1.4:1. The thyroid gland was diffusely enlarged in 46%, small, nodular, or gritty in 46%, and impalpable in 8%. Thyroid scanning revealed diffuse isotope uptake in 40% and patchy uptake in 60%. Ablative doses of 10 or 15 mCi of iodine 131 were given to 78 patients. The patients who became hypothyroid have been followed for a median of 18 months. Of these, 37% were hypothyroid at 3 months, 58% at 6 months, 63% at 9 months, and 68% at 12 months. The clinical presentation of hyperthyroidism appears to differ in Saudi Arabia compared with Western countries. The female:male ratio is significantly lower (P < 0.001), and classical Graves' disease less frequent. In large countries where follow-up may be difficult, ablative radioiodine treatment and subsequent thyroxine replacement have advantages over other treatments.

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Thyrotoxic periodic paralysis in a Saudi Arab

Johnson

Hoque

1992

J of Inher Metab Disea

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Periodic paralysis is an uncommon complication of thyrotoxicosis. Over 90% of reported cases have occurred in Orientals. Its occurrence in non-Orientals is rare. We report a case of thyrotoxic periodic paralysis (McKusick 188580) in a Saudi Arab male.A 26-year-old Saudi Arab male presented to emergency room with a complaint of profound weakness in both lower limbs, which he noticed upon waking in the morning. There were no other complaints. He had been well until one week before when he was seen in the outpatient clinic and noted to be anxious, tremulous and tachycardiac. At that time, his T3 uptake was 0.45 and his total T4 was 192 nmot/L. Thyroid-stimulating immunoglobulin was elevated.Graves thyrotoxicosis was diagnosed and he was discharged on propylthiouracil 100mg three times daily and propranolol 20mg three times daily, but he did not take these medications. He worked as a manual labourer outside in the hot climate that prevails in Eastern Saudi Arabia. His diet consisted primarily of rice and lamb and his principal beverage was sweetened tea. His family history was negative for familial periodic paralysis.Physical examination was remarkable for an alert but anxious patient. Lid tag and lid retraction were present but there was no exophthalmos. He had a diffuse thyroid goitre but no bruit. Neurologically, his deep tendon reflexes were symmetrically decreased in the lower extremities. Motor strength was 3/5 in the upper extremities and 1/5 in the lower extremities. Sensation was normal. Routine laboratory tests were remarkable only for a potassium of 1.8 nmol/L. Electrocardiography showed sinus tachycardia, a prolonged corrected QT interval and widespread ST depressions and T inversions.Potassium was infused intravenously. As the patient became eukalaemic, muscle strength was restored and the ECG abnormalities, except tachycardia, cleared. He was subsequently treated with radioactive iodine and, at follow-up a year later he was euthyroid and free from recurrences of periodic paralysis. All medications have been discontinued.In Japan, periodic paralysis complicates approximately 2% of cases of thyrotoxicosis (Okinaka et al 1957). There is a male-to-female preponderance of about 16:1, and approximately 13% of Japanese thyrotoxic males develop periodic paralysis. In China, periodic paralysis also occurs in about 2% of all cases of thyrotoxicosis Saudi Aramco/A1

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Thyrotoxicosis: Experience from the King Khalid University Hospital, Riyadh

Cited by 7 publications

References 10 publications

Isoniazid acetylation phenotyping in Saudi Arabs

Isoniazid acetylation phenotyping in Saudi Arabs

High-Dose Iodine 131 Treatment of Hyperthyroidism: Experience at King Faisal Specialist Hospital and Research Centre

Thyrotoxic periodic paralysis in a Saudi Arab

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