Thyrotoxicosis in a Mongol

Gilchrist, Leo

doi:10.1136/bmj.1.4441.237-a

Cited by 11 publications

(5 citation statements)

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“…The aetiology of acquired hypothyroidism remains uncertain, although it is probably secondary to auto-immune thyroiditis (see "immunological aspects"). Gilchrist (1946) described the first case of a person with Down syndrome with a goitre secondary to hyperthyroidism. Table 4 lists other reports.…”

Section: Reports Of Hypothyroidism and Hyperthyroidismmentioning

confidence: 99%

Down Syndrome and Thyroid Disorders: A Review

Prasher¹

1999

Downs Syndr. Res. Pract.

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Thyroid disorders are common in the Down syndrome population but many specific areas of importance remain to be resolved. A detailed review of previously published case reports and research studies highlighting the clinical association between Down syndrome and thyroid disorders was undertaken. Historical, epidemiological, immunological, diagnostic and treatment issues are addressed. Recommendations for future management and research are considered.

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Section: Reports Of Hypothyroidism and Hyperthyroidismmentioning

confidence: 99%

Down Syndrome and Thyroid Disorders: A Review

Prasher¹

1999

Downs Syndr. Res. Pract.

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“…[ 4 ] The first such case was published in 1946 by Gilchrist. [ 5 ] The reported worldwide literature on hyperthyroidism in DS is that of about 112 sporadic cases with only three to four cases from India. We describe one such case in an adult male of DS with hyperthyroidism (Graves’ disease) who was administered oral Iodine-131 as a definitive treatment.…”

Section: Introductionmentioning

confidence: 99%

Radioactive iodine-131 as a definitive treatment in rare association of down syndrome with hyperthyroidism: A case report and review of literature

2017

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Down syndrome characterized by trisomy of chromosome 21 is frequently associated with thyroid dysfunctions due to underlying autoimmune disorders. Hypothyroidism is the commonest thyroid dysfunction and hyperthyroidism, usually Graves’ disease, is far less common. On literature review, we came across approximately 112 cases reported so far with the first such case report in 1946. The published data from India on hyperthyroidism in Down syndrome is of three case reports. We report one such patient, an adult male of 28 years who was administered Iodine-131 as a definitive treatment after 9-10 years of initial diagnosis.

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“…1 However, both hypothyroidism 2 and hyperthyroidism 3 have been reported. 2,3 The prevalence of hypothyroidism in Down syndrome is estimated at 0.12%.…”

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confidence: 99%

“…1 However, both hypothyroidism 2 and hyperthyroidism 3 have been reported. 2,3 The prevalence of hypothyroidism in Down syndrome is estimated at 0.12%. 4 Hypothyroidism is the commonest form of thyroid disorder to be associated with Down syndrome.…”

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confidence: 99%

Down syndrome associated with hypothyroidism and chronic pericardial effusion: echocardiographic follow-up

Said

Droste²,

Derks³

et al. 2007

NHJL

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We present a 39-year-old male patient with Down syndrome who was evaluated for fatigue, palpitations and bouts of cyanosis. Physical examination showed features of trisomy-21(Down syndrome), with a slow pulse rate, distant cardiac sounds and absent apex beat. He had normal jugular venous pressure without pulsus paradoxus. The ECG showed QRS microvoltage and flattened P and T segments. The 48-hour ambulatory ECG depicted normal sinus rhythm with intermittent short PR interval without tachyarrhythmias. The chest Xray revealed cardiomegaly without pulmonary venous congestion. Although serial transthoracic echocardiographic examination demonstrated pericardial effusion with features of tamponade, there were no overt signs of clinical cardiac tamponade. Biochemically, the serum thyroxine of 3 pmol/l (normal 10 to 25) and thyroid-stimulating hormone of 160 mU/l (normal 0.20 to 4.20)) were compatible with hypothyroidism. The patient was treated with L-thyroxine sodium daily, which was gradually increased to 0.125 mg daily. Within a few months he lost weight and became more alert; furthermore, the symptoms of hypothyroidism and the pericardial effusion resolved. It can be concluded that Down syndrome may be associated with hypothyroidism and pericardial effusion. These were alleviated following hormone replacement. Regular evaluation of thyroid function tests is important in Down syndrome. (Neth Heart J 2007;15:67-70.).

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Thyrotoxicosis in a Mongol

Cited by 11 publications

References 0 publications

Down Syndrome and Thyroid Disorders: A Review

Down Syndrome and Thyroid Disorders: A Review

Radioactive iodine-131 as a definitive treatment in rare association of down syndrome with hyperthyroidism: A case report and review of literature

Down syndrome associated with hypothyroidism and chronic pericardial effusion: echocardiographic follow-up

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