Thyrotropic hormone (TSH) regulation of triiodothyronine (T3) concentration in immune cells

Csaba, G.; Pállinger, Éva

doi:10.1007/s00011-008-8076-8

Cited by 39 publications

(33 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These actions can include the regulation of the synthesis and release of mediators of inflammation, such as IL6 and tumor necrosis factor-a (TNF-a). Various immune system cells have also been found to express T 3 , a process that is under the influence of TSH (40). It has thus been hypothesized that the immune system cells can affect the systemic thyroid hormone activity.…”

Section: Discussionmentioning

confidence: 99%

Association between thyroid function tests at baseline and the outcome of patients with sepsis or septic shock: a systematic review

Angelousi

Karageorgopoulos

Kapaskelis

et al. 2011

European Journal of Endocrinology

View full text Add to dashboard Cite

Introduction: The severity of critical illness is associated with various patterns of thyroid hormone abnormalities. We sought to evaluate whether the outcome of patients with, specifically, sepsis or septic shock is associated with the thyroid function tests evaluated at diagnosis or admission in the intensive care unit (ICU). Methods: We performed a systematic review of relevant studies by searching PubMed. Results: We included nine studies that all had a prospective cohort design. Seven involved children or neonates, and two involved adults. Mortality was the outcome evaluated in eight studies, while the length of ICU stay was evaluated in the remaining study. In univariate analysis, six of the nine included studies showed that either, free or total, triiodothyronine or thyroxine was lower in the group of patients with sepsis or septic shock who had unfavorable outcome than in those who had favorable outcome. Two other studies showed higher TSH values in the group of patients with unfavorable outcome. No significant relevant findings were observed in the remaining study. Regarding the correlation of sepsis prognostic scoring systems with thyroid function tests, the three studies that provided specific relevant data showed variable findings. Discussion: Most of the relevant studies identified favor the concept that decreased thyroid function at baseline might be associated with a worse outcome of patients with sepsis or septic shock. Although these findings are not consistent, the role of thyroid function in affecting or merely predicting the outcome of sepsis or septic shock merits further investigation.

show abstract

Section: Discussionmentioning

confidence: 99%

Association between thyroid function tests at baseline and the outcome of patients with sepsis or septic shock: a systematic review

Angelousi

Karageorgopoulos

Kapaskelis

et al. 2011

European Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…Studying the hormone content of thymocytes, triiodothyronine (T3, regulated by TSH) [69][70][71], adrenocorticotropic hormone (ACTH), beta-endorphin [72], histamine, and serotonin [69] were found. T3 level is changing, and is dependent on the light-dark cycle [73].…”

Section: Effect Of Thymic Self-hormones On Non-immune Cells and Functmentioning

confidence: 99%

“…Thyroid hormones upregulate thymulin production [32,85]. Hypothyroidism (caused by drugs) provokes the involution of thymus [95], manifested in enhanced thymocyte development [96] and T3 production by it [71]. Insulin, oxytocin, gonadotropin, and EGF strongly influenced ACTH, endorphin and T3 production by thymocytes, while ACTH synthesis was reduced [70] in in vitro experiments.…”

Section: Effect Of Other (Non-thymic-self) Hormones On the Thymusmentioning

confidence: 99%

The Immunoendocrine Thymus as a Pacemaker of Lifespan

Csaba¹

2016

Acta Microbiologica et Immunologica Hungarica

View full text Add to dashboard Cite

The thymus develops from an endocrine area of the foregut, and retains the ancient potencies of this region. However, later it is populated by bone marrow originated lymphatic elements and forms a combined organ, which is a central part of the immune system as well as an influential element of the endocrine orchestra. Thymus produces self-hormones (thymulin, thymosin, thymopentin, and thymus humoral factor), which are participating in the regulation of immune cell transformation and selection, and also synthesizes hormones similar to that of the other endocrine glands such as melatonin, neuropeptides, and insulin, which are transported by the immune cells to the sites of requests (packed transport). Thymic (epithelial and immune) cells also have receptors for hormones which regulate them. This combined organ, which is continuously changing from birth to senescence seems to be a pacemaker of life. This function is basically regulated by the selection of self-responsive thymocytes as their complete destruction helps the development (up to puberty) and their gradual release in case of weakened control (after puberty) causes the erosion of cells and intercellular material, named aging. This means that during aging, self-destructive and non-protective immune activities are manifested under the guidance of the involuting thymus, causing the continuous irritation of cells and organs. Possibly the pineal body is the main regulator of the pacemaker, the neonatal removal of which results in atrophy of thymus and wasting disease and its later corrosion causes the insufficiency of thymus. The co-involution of pineal and thymus could determine the aging and the time of death without external intervention; however, external factors can negatively influence both of them.

show abstract

“…В ряде исследований [16,17] обсуждается воз-можная позитивная роль МС в восстановлении функции ЩЖ с гипотиреозом в эутиреоидное состояние после бактериального NTI («не тире-оидной болезни»). Клетки системы иммунитета, в том числе МС [10], содержат Т3 (трийодтиро-нин), синтез которого регулируется у них ТТГ, что предполагает непосредственное участие им-муноцитов в регулировании тиреоидного статуса.…”

Section: патогенез аутоиммунных заболеванийunclassified