Thyrotropin-producing adenomas and thyrotropic hyperplasia (clini­cal case reports and the review of the literature)

Астафьева, Л. И.; Кадашев, Б А; Shishkina, L V; Kalinin, Pavel; Kutin, Maxim; Sidneva, Yuliya; Sharipov, Oleg

doi:10.17116/neiro201680382-90

Cited by 2 publications

(1 citation statement)

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“…Однако отсутствие дальнейшего уменьшения концентра ции ТТГ позволило подтвердить тиреотропиному. Существует мнение, что данные образования гипофиза являются резуль татом длительного некомпенсированного гипотиреоза [16]. Однако в нашем случае у пациентки наблюдалось также повышение свободных фракций тиреоидных гормонов вследствие избыточного приема левотироксина, то есть можно говорить о самостоятельном развитии опухоли гипофиза.…”

Section: Discussionunclassified

TSH-secreting pituitary adenoma in combination with primary hypothyroidism in the outcome of Hashimoto’s disease: diagnostic difficulties

et al. 2018

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Despite the fact that pituitary adenomas are among the most frequent brain tumours, TSH-secreting pituitary adenomas (thyrotropinomas) are less than 1% of all adenomas. Due to the increase in the free fractions of thyroid hormones at normal or elevated TSH levels, the majority of patients with these pituitary adenomas have a long anamnesis of thyrotoxicosis which requires a differential diagnosis with thyroid pathology (Graves’ disease, toxic adenoma, autonomously functioning thyroid nodules). The diagnosis of the thyrotropinoma is quite challenging for clinicians. This article describes the case of a combination of the thyrotropinoma with primary hypothyroidism as a result of the Hashimoto’s disease. A feature of this article is the absence of a typical clinical picture of thyrotoxicosis in combination with an evaluated level of TSH on the background of constantly increasing substitution therapy for primary hypothyroidism. The picture of space-occupying lesion according to MRI of the brain allowed to suspect hormone-active pituitary adenoma (macroadenoma). As a result of surgical treatment (endonasal transsphenoidal adenomectomy), the level of TSH and free thyroid hormone levels were normalized in the postoperative period. The diagnosis of TSH-secreting pituitary adenoma was confirmed by histological and immunohistochemical analysis of postoperative material.

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Section: Discussionunclassified

TSH-secreting pituitary adenoma in combination with primary hypothyroidism in the outcome of Hashimoto’s disease: diagnostic difficulties

et al. 2018

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Radiological evolution of pituitary hyperplasia in primary hypothyroidism and its differentiation from nonfunctioning pituitary adenoma coexisting with primary hypothyroidism

Nikith,

Krishnappa,

Lakkundi

et al. 2024

Endocrine

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Thyrotropin-producing adenomas and thyrotropic hyperplasia (clinical case reports and the review of the literature)

Cited by 2 publications

References 20 publications

TSH-secreting pituitary adenoma in combination with primary hypothyroidism in the outcome of Hashimoto’s disease: diagnostic difficulties

TSH-secreting pituitary adenoma in combination with primary hypothyroidism in the outcome of Hashimoto’s disease: diagnostic difficulties

Radiological evolution of pituitary hyperplasia in primary hypothyroidism and its differentiation from nonfunctioning pituitary adenoma coexisting with primary hypothyroidism

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Thyrotropin-producing adenomas and thyrotropic hyperplasia (clini­cal case reports and the review of the literature)

Cited by 2 publications

References 20 publications

TSH-secreting pituitary adenoma in combination with primary hypothyroidism in the outcome of Hashimoto’s disease: diagnostic difficulties

TSH-secreting pituitary adenoma in combination with primary hypothyroidism in the outcome of Hashimoto’s disease: diagnostic difficulties

Radiological evolution of pituitary hyperplasia in primary hypothyroidism and its differentiation from nonfunctioning pituitary adenoma coexisting with primary hypothyroidism

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Thyrotropin-producing adenomas and thyrotropic hyperplasia (clinical case reports and the review of the literature)