Thyrotropin receptor autoantibodies and early miscarriages in patients with Hashimoto thyroiditis: a case–control study

Toulis, Konstantinos; Goulis, Dimitrios G.; Tsolakidou, Konstantina; Hilidis, Ilias; Fragkos, Marios; Polyzos, Stergios A.; Gerofotis, A.; Kita, Marina; Bili, Helen; Vavilis, Dimitrios; Daniilidis, M.; Tarlatzis, Basil C.; Papadimas, Ioannis

doi:10.3109/09513590.2013.801449

Cited by 2 publications

(2 citation statements)

References 24 publications

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“…Although the TSH-like actions of hCG require further research, a 2009 study suggested a link between thyroid autoimmunity and miscarriage 71 . However, conflicting data raise concerns about this hypothesis 72 . Finally, gestational hyperthyroidism has been linked to the expression of TSHR gene variants with hCG hypersensitivity 73 .…”

Section: Recent Advancesmentioning

confidence: 99%

Recent advances in understanding gonadotropin signaling

Casarini¹,

Simoni²

2021

Fac Rev

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Gonadotropins are glycoprotein sex hormones regulating development and reproduction and bind to specific G protein–coupled receptors expressed in the gonads. Their effects on multiple signaling cascades and intracellular events have recently been characterized using novel technological and scientific tools. The impact of allosteric modulators on gonadotropin signaling, the role of sugars linked to the hormone backbone, the detection of endosomal compartments supporting signaling modules, and the dissection of different effects mediated by these molecules are areas that have advanced significantly in the last decade. The classic view providing the exclusive activation of the cAMP/protein kinase A (PKA) and the steroidogenic pathway by these hormones has been expanded with the addition of novel signaling cascades as determined by high-resolution imaging techniques. These new findings provided new potential therapeutic applications. Despite these improvements, unanswered issues of gonadotropin physiology, such as the intrinsic pro-apoptotic potential to these hormones, the existence of receptors assembled as heteromers, and their expression in extragonadal tissues, remain to be studied. Elucidating these issues is a challenge for future research.

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Section: Recent Advancesmentioning

confidence: 99%

Recent advances in understanding gonadotropin signaling

Casarini¹,

Simoni²

2021

Fac Rev

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“…Nevertheless, approximately 79.3% of HT patients display a euthyroid state at diagnosis and may retain normal thyroid function for many years [8, 9]. In recent years, the association between euthyroid HT and pregnancy loss has drawn attention [10, 11]. Data from the literature suggest that the leading single cause of pregnancy failure is embryo implantation error, which can occur at a rate of up to 78% in humans [12].…”

Section: Introductionmentioning

confidence: 99%

Hashimoto’s thyroiditis impairs embryo implantation by compromising endometrial morphology and receptivity markers in euthyroid mice

Cai

Qin

et al. 2019

Reprod Biol Endocrinol

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BackgroundAlthough thyroid dysfunction caused by Hashimoto’s thyroiditis (HT) is believed to be related to implantation failure due to the underdevelopment of the receptive uterus, it is unknown whether HT itself, even in the euthyroid state, impairs embryo implantation associated with endometrial receptivity defects. To address whether HT itself can affect endometrial receptivity accompanied by implantation alterations, a euthyroid HT model was established in mice.MethodsFemale NOD mice were immunized twice with thyroglobulin and adjuvant to induce the experimental HT model. Four weeks after the second treatment, the mice were normally mated, and pregnant ones were sacrificed in implantation window for thyroid-related parameter and steroid hormones measurements by electrochemiluminescence immunoassay and enzyme-linked immunosorbent assay and implantation site number calculation by uptake of Chicago Blue dye. In addition, certain morphological features of endometrial receptivity were observed by hematoxylin-eosin staining and scanning electron microscopy, and the expression of other receptivity markers were analyzed by immunohistochemistry, RT-qPCR or Western Blot.ResultsHT mice displayed intrathyroidal monocyte infiltration and elevated serum thyroid autoantibody levels without thyroid dysfunction, defined as euthyroid HT in humans. Euthyroid HT resulted in implantation failure, fewer pinopodes, retarded pinopode maturation, and inhibited expression of receptivity markers: estrogen receptor α (ERα), integrin β3, leukemia inhibitory factor (LIF), and cell adhesion molecule-1 (ICAM-1). Interestingly, despite this compromised endometrial receptivity response, no statistical differences in serum estradiol or progesterone level between groups were found.ConclusionsThese findings are the first to indicate that HT induces a nonreceptive endometrial milieu in the euthyroid state, which may underlie the detrimental effects of HT itself on embryo implantation.

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Thyrotropin receptor autoantibodies and early miscarriages in patients with Hashimoto thyroiditis: a case–control study

Cited by 2 publications

References 24 publications

Recent advances in understanding gonadotropin signaling

Recent advances in understanding gonadotropin signaling

Hashimoto’s thyroiditis impairs embryo implantation by compromising endometrial morphology and receptivity markers in euthyroid mice

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