Thyrotropin-releasing hormone and its receptor in glia

Fernández-Agulló, Teresa

doi:10.1002/1098-1136(20010315)33:4<267::aid-glia1025>3.0.co;2-1

Cited by 2 publications

(1 citation statement)

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“…Plasma T4 and T3, as well as T3 locally produced in the brain, provide negative‐feedback regulating the production of TRH and TSH. Limited evidence, largely from in vitro studies, suggests that astrocytes may be direct targets of action of TRH via receptors expressed on their surface, although the physiological relevance of this remains unclear.…”

Section: Astrocytes and The Neuroendocrine Regulation Of Energy Homeomentioning

confidence: 99%

Astrocytes in neuroendocrine systems: An overview

Macdonald

Robb

Morrissey

et al. 2019

J Neuroendocrinology

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A class of glial cell, astrocytes, is highly abundant in the central nervous system (CNS). In addition to maintaining tissue homeostasis, astrocytes regulate neuronal communication and synaptic plasticity. There is an ever‐increasing appreciation that astrocytes are involved in the regulation of physiology and behaviour in normal and pathological states, including within neuroendocrine systems. Indeed, astrocytes are direct targets of hormone action in the CNS, via receptors expressed on their surface, and are also a source of regulatory neuropeptides, neurotransmitters and gliotransmitters. Furthermore, as part of the neurovascular unit, astrocytes can regulate hormone entry into the CNS. This review is intended to provide an overview of how astrocytes are impacted by and contribute to the regulation of a diverse range of neuroendocrine systems: energy homeostasis and metabolism, reproduction, fluid homeostasis, the stress response and circadian rhythms.

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Section: Astrocytes and The Neuroendocrine Regulation Of Energy Homeomentioning

confidence: 99%