Thyrotropin-Releasing Hormone in the Hypothalamus of the Rat

Bassiri, Rahim M.; Utiger, Robert D.

doi:10.1210/endo-94-1-188

Cited by 81 publications

(40 citation statements)

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“…This conclusion would accord with the fact that hypothalamic TRH content is normal in hypothyroid rats (23). However, with respect to both mild and severe hypothyroidism in man, definitive conclusions concerning the relative roles of increased TRH secretion and enhanced pituitary responsiveness in augmenting TSH secretion must await the development of methods for measuring the rate of TRH secretion.…”

Section: Resultsmentioning

confidence: 89%

Hyperresponse to Thyrotropin-Releasing Hormone Accompanying Small Decreases in Serum Thyroid Hormone Concentrations

Vagenakis¹,

Rapoport²,

Azizi³

et al. 1974

J. Clin. Invest.

113

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Section: Resultsmentioning

confidence: 89%

Hyperresponse to Thyrotropin-Releasing Hormone Accompanying Small Decreases in Serum Thyroid Hormone Concentrations

Vagenakis¹,

Rapoport²,

Azizi³

et al. 1974

J. Clin. Invest.

113

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“…Since radioimmunoassay of TRH is as much sensitive as determining TRH in hypothalamic and brain tissues, most papers dealt with distribution of TRH in the tissues (Bassiri and Utiger, 1974;Jackson et al, 1974;Oliver et al, 1974;Saito et al, 1974 thalamic control of thyrotropin secretion will be elucidated in detail. The disappearance of TRH from human blood is rapid (t1/2=4-12 min) in our cases as presented by May and Donabedian (1973).…”

Section: Discussionmentioning

confidence: 99%

Radioimmunoassay of Thyrotropin Releasing Hormone in Plasma and Urine

et al. 1975

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“…Serum TSH was measured by RIA with material kindly distributed by the National Pituitary Agency, National Institute of Arthritis, Metabolism, and Digestive Diseases (Dr. A. Parlow). Hypothalamic and serum TRH was assayed by RIA by the method of Bassiri and Utiger (16)(17)(18) as modified in our laboratory (19). Serum T3 and T4 concentrations were measured by RIA.…”

Section: Methodsmentioning

confidence: 99%

Thyrotropin-Releasing Hormone is not Required for Thyrotropin Secretion in the Perinatal Rat

Theodoropoulos¹,

Braverman²,

Vagenakis³

1979

J. Clin. Invest.

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A B S T R A C T To determine the role of thyrotropinreleasing hormone (TRH) in the regulation of thyroidstimulating hormone (TSH) secretion in the perinatal period, a physiological approach of neutralizing circulating TRH in the fetal andl early neonatal rat was employed. TRH-antiserum (TRH-AS) raised in rabbits and administered daily to low iodine-propylthiouracil (LID-PTU)-fed pregnant rats from days 12 to 19 of gestation markedly impaired the rise in serum TSH to LID-PTU when compared with normal rabbit serumtreated controls. In contrast, fetal serum TSH was unaffected by TRH-AS. The binding capacity of TRH-AS in the fetal serum (111 ng/iiil) far exceeded circulating TRH in the fetus. Similarly7, acute TRH-AS administration to the pregnant rat fed LID-PTU markedly decreased the serum TSH concentration in the mother, but not in the fetus, 60 niin after TRH-AS administration. Chronic TRH-AS administration to neonatal rats whose nursing mothers were fed LID-PTU was ineffective in decreasing the elevated serum TSH in the neonate through day 8 of life, whereas a slight but significant decrease in serum TSH was observed on day 10. Chronic daily TRH-AS administration to neonatal rats through day 10 of life had no effect on the later development of the hypothalamic-pituitary-thyroid axis. These findings suggest that TRH does not participate in TSH regulation during the perinatal life in the rat and that thyroid hormones are probably the main regulators of TSH secretion during this period.Placental TRH is niot importanit in regulating TSH secretion in the fetal rat. Furthermore, TRtH "deprivation" during neonatal life does not prevent normal later developmenit of the hypothalamic-pituitarythyroid axis.

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Thyrotropin-Releasing Hormone in the Hypothalamus of the Rat

Cited by 81 publications

References 0 publications

Hyperresponse to Thyrotropin-Releasing Hormone Accompanying Small Decreases in Serum Thyroid Hormone Concentrations

Hyperresponse to Thyrotropin-Releasing Hormone Accompanying Small Decreases in Serum Thyroid Hormone Concentrations

Radioimmunoassay of Thyrotropin Releasing Hormone in Plasma and Urine

Thyrotropin-Releasing Hormone is not Required for Thyrotropin Secretion in the Perinatal Rat

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