Thyrotropin (TSH) Release During Altered Adrenergic α and β Receptor Influence

Ub, Lauridsen; Faber, Jens; Friis, T; Kirkegaard, C.; Nerup, Jørgen

doi:10.1055/s-0028-1095625

Cited by 18 publications

(3 citation statements)

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“…The study reported by Langer et al (1980) is in support of this view. However, in other studies, neither adrenergic manipulation nor short term administration of antidepressant drugs affected TSH-release on TRH-load (Lauridsen et al (1976), Kirkegaard et al (1977), Widerlöv et al (1978». According toEhrensing et aL (1974 and Kirkegaard et al (1975) a…”

Section: Discussionmentioning

confidence: 91%

Nortriptyline and Pituitary-Thyroid Function in Affective Disorder

Nordgren¹,

C²

1981

Pharmacopsychiatry

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Twenty out-patients with depressive illness were studied with regard to thyroid hormone concentrations, basal and TRH-stimulated TSH, and prolactin levels before and during treatment with nortriptyline. Concentrations of plasma nortriptyline and 10-hydroxy-nortripyline were analysed while on 75 mg and 150 mg/day. No correlations between clinical outcome and side effects on the one hand and drug concentrations on the other were demonstrated. Provided the age factor was considered, basal and stimulated hormone levels did not differentiate between healthy controls and patients with "endogenous" and those with "exogenous" depression. Nortriptyline treatment did not influence serum hormone levels.

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Section: Discussionmentioning

confidence: 91%

Nortriptyline and Pituitary-Thyroid Function in Affective Disorder

Nordgren¹,

C²

1981

Pharmacopsychiatry

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“…Birk Lauridsen et al (1976) also failed to detect significant influence of isoproterenol (ß-stimulator) and propranolol on TRH-induced TSH re¬ lease. Birk Lauridsen et al (1976) also failed to detect significant influence of isoproterenol (ß-stimulator) and propranolol on TRH-induced TSH re¬ lease.…”

Section: Discussionmentioning

confidence: 94%

Influence of terbutaline on TRH-induced prolactin and thyrotropin release in normal subjects

Röjdmark¹

1986

Acta Endocrinologica

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To investigate whether terbutaline (T) influences the release of prolactin (Prl) and/or thyrotropin (TSH) from the anterior pituitary, 25 \g=m\gthyrotropin-releasing hormone (TRH) was injected iv in 7 normal subjects who were pre-treated orally with either T or placebo. The TRH-induced Prl response, as reflected by the Prl incremental area, was more pronounced after priming with placebo (2071 \m=+-\606) than after T (1391 \ m=+-\434; P < 0.05). In contrast, the TRH\x=req-\ elicited TSH responses did not differ significantly after the two pre-treatments. When TRH was given to 8 additional individuals on iv background infusion of either T or saline, the Prl response was significantly larger during saline (2123 \m=+-\354) than during T infusion (1540 \m=+-\235; P < 0.01), whereas the TSH responses were of similar magnitudes. Six subjects, given 25 \ g=m\ g TRH iv on background infusion of T or saline, were also given propranolol orally before commencement of the T infusion and placebo before the saline infusion. This resulted in similar Prl responses and also in similar TSH responses, during the two background treatments. The results imply that oral as well as iv administration of T has inhibitory influence on human lactotrophs, but lacks measurable effect on thyrotrophs.

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“…16,17 Data by Faglia et al 18 indicate that TRH mediated TSH release is inhibited by dopamine and possibly by serotonin. There are no definitive data that in humans norepinephrine has a stimulating action on the release of TRH and consequently of TSH 19 as it happens in the rat, 20,23 through ScanIon et al 24,25 lead to believe that this is the case. On the basis of these data of the literature, our findings showing an increase of PRL and STH responses, normal gonadotropins release and decrease of TSH secretion cannot be interpreted as the expression of a diminution of the dopamine effect or as an involvement of noradrenergic neurotransmission, since these situations do not explain the observed responses taken together.…”

Section: Discussionmentioning

confidence: 99%

Neuroendocrine Data in Chronic Post‐traumatic Headache

et al. 1982

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Twenty chronic post-traumatic headache subjects (16 men and 4 women) were considered, together with age and sex matched normal controls. Pituitary function was challenged by means of luteinising hormone releasing hormone (100 microg, i.v.), thyrotropin (TSH) releasing hormone (200 microg, i.v.) and regular insulin (.1 U/kg, i.v.). The responses of gonadotropins, TSH, somatotropin (STH) and prolactin (PRL) were studied in the group as a whole and in clinical subgroups. No differences were found in the baseline levels of the hormones. No significant changes were observed in the responses of gonadotropins and STH. A decreased response was found for TSH and, in the female series, an enhanced response of PRL was observed. Patients complaining for a decreased libido showed a larger PRL response. The smaller response of TSH exhibits a straight inverse relationship to the clinical severity. The periodicity of PRL secretion studied in male patients with a harmonic analysis according to the Fourier's theorem showed the preservation of the physiological sleep-entrained night surge. The per cent incidence of the harmonics with a period shorter than 24 hours decreases according to the clinical severity, at variance to the finding in normal controls. The only persisting harmonic is the one with a 24 hour period. In the absence of major post-traumatic endocrine syndromes, post-traumatic headache subjects show changes of the neuroendocrine regulation of pituitary secretion. The findings are consistent with the hypothesis of an hyperactivity of serotoninergic neurotransmission.

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Thyrotropin (TSH) Release During Altered Adrenergic α and β Receptor Influence

Cited by 18 publications

References 0 publications

Nortriptyline and Pituitary-Thyroid Function in Affective Disorder

Nortriptyline and Pituitary-Thyroid Function in Affective Disorder

Influence of terbutaline on TRH-induced prolactin and thyrotropin release in normal subjects

Neuroendocrine Data in Chronic Post‐traumatic Headache

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