Thyroxine-Binding Globulin in Spontaneous Abortion

Skjöldebrand, Lottie; Brundin, Jan; Carlström, Anders; Pettersson, Tom

doi:10.1159/000298952

Cited by 12 publications

(8 citation statements)

References 12 publications

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“…[8] During preeclampsia, involvement of liver and kidney may lead on to decreased peripheral conversion of T 4 to T 3 ; hence, decreasing T 3 levels. [9] Also, “low T 3 syndrome” has been reported in preeclampsia. [10] Loss of proteins and protein-bound hormones in the urine of preeclamptics may also contribute to low TT 3 levels.…”

Section: Discussionmentioning

confidence: 99%

Correlation of Thyroid Functions with Severity and Outcome of Pregnancy

Kharb

Sardana

Nanda

2013

Ann Med Health Sci Res

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Background:During normal pregnancy, changes in thyroid function are well documented; however, information regarding thyroid function in preeclampsia is scanty.Aim:The present study was planned to study thyroid hormones in mild and severe preeclamptic women and normotensive women and correlate them with outcome of pregnancy.Subject and Methods:Thyroid hormones were analyzed in mild (n = 50) and severe (n = 50) cases of preeclamptic women and normotensive women (n = 100).Results:Thyroid-stimulating hormone (TSH) and TT4 levels were higher in mild preeclampsia as compared with severe preeclampsia (P < 0.001 and P < 0.01, respectively). TT3 levels were lower in preeclampsia (more so in severe preeclamptics as compared with normotensive pregnant and non-pregnant women). Preeclamptic with raised TSH levels had significantly higher mean arterial blood pressure and low birth weight (BW). A negative correlation was observed between BW and TSH levels (r = 0.296, P < 0.001) and BW and TT4 levels. A positive correlation was observed between BW and TT3 levels.Conclusion:These findings indicate that there is a state of biochemical hypothyroidism that correlates with severity of preeclampsia and influences obstetric outcome in these women. Identification of thyroid hormone in pregnancy might be of help in predicting occurrence of preeclampsia.

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Section: Discussionmentioning

confidence: 99%

Correlation of Thyroid Functions with Severity and Outcome of Pregnancy

Kharb

Sardana

Nanda

2013

Ann Med Health Sci Res

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“…The infant birth weight was found to be related to the maternal serum albumin level in situa tions where there was heavy proteinuria such as the nephrotic syndrome [10], In normal pregnancy, the increasing production of pla cental estrogen during pregnancy stimulates the hepatic synthesis of TBG [11][12][13][14][15], and this is reflected by a decrease in T3U [16]. As TBG concentration is reported to be lower in unsuccessful pregnancies [17], this decrease may be a useful indicator of placental function deteriora tion in pregnancy [5], We think that the placental dys function may cause failure in estrogen production, there fore decrease in TBG, TT3 and TT4 and simultaneously growth failure to the fetus. We found a significant correla tion between birth weight and maternal TBG levels which was similar to that of Lao et al [5].…”

Section: Bw -Ft 4imentioning

confidence: 99%

Relation between Birth Weight and Thyroid Function in Preeclampsia-Eclampsia

Kaya¹,

Şahin²,

Özkeçeci³

et al. 1994

Gynecol Obstet Invest

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Maternal thyroid function was investigated in 37 preeclamptic and 8 eclamptic patients and 45 normal pregnant women in the third trimester as controls. There were significant correlations between maternal values of total thyroxine (TT₄), total triiodothyronine (TT₃), thyroxine-binding globulin, free thyroxine index and birth weight of newborns in the patients with preeclampsia-eclampsia, but there was no correlation in the controls. Also, the maternal free thyroxine, free triiodothyronine, triiodothyronine uptake and thyroid stimulating hormone values showed no correlation with the birth weights of babies in both groups. The reduced serum concentrations of TT₄ and TT₃ may reflect the severity of preeclampsia.

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“…Both TBG and T3U reflect the plasma concentration of thyroid-hormone-binding protein, and in normal pregnancy, TBG concentration increases and this is reflected by a decrease in T3U, due to the effect of increased circulating oestrogen concentration [7], Our findings may therefore reflect the circulating oestrogen level, which has been shown to be low in association with pre-eclampsia and fetal growth retardation [8]. As TBG concentration is reported to be lower in unsuccessful pregnancies [5], a decreased TBG concentration may be a useful indicator of deterioration of placental function in pregnancy.…”

Section: Discussionmentioning

confidence: 66%

“…Changes in thyroxine-binding globulin (TBG) in particular merits further examination. A relationship between a low TBG level and habitual abortion has been reported [3,4], In a recent study [5], significantly lower values of TBG were found in women with spontaneous abortion. Thus, the measurement of TBG may be useful in the assessment of pre-eclamptic pregnancies.…”

Section: Introductionmentioning

confidence: 84%

Birth Weight and Thyroxine-Binding Globulin in Pre-Eclampsia

Lao¹,

Chin²,

Panesar

et al. 1989

Gynecol Obstet Invest

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Plasma concentrations of thyroxine (T₄) and thyroxine-binding globulin (TBG) as well as triiodothyronine uptake (T₃U) were measured in 32 proteinuric pre-eclamptic patients and 24 normotensive pregnant women at similar gestations in the third trimester. The pre-eclamptic patients had slightly lower TBG, and significantly lower T₄, concentrations, which were significantly correlated. They also had significantly lower infant birth weight which was correlated to the TBG and T₃U values. There was no correlation between T₄ and TBG or between birth weight and TBG or T₃U in the normotensive women. It is likely that the correlation between TBG and birth weight in the pre-eclamptic patients reflects the severity of proteinuria in pre-eclampsia.

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Thyroxine-Binding Globulin in Spontaneous Abortion

Cited by 12 publications

References 12 publications

Correlation of Thyroid Functions with Severity and Outcome of Pregnancy

Correlation of Thyroid Functions with Severity and Outcome of Pregnancy

Relation between Birth Weight and Thyroid Function in Preeclampsia-Eclampsia

Birth Weight and Thyroxine-Binding Globulin in Pre-Eclampsia

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