Thyroxine changes in COVID-19 pandemic: A systematic review and meta-analysis

Li, Ziqi; Hou, Pengwei; Mu, Shuwen; Wang, Renzhi; Miao, Hongjun; Feng, Mang; Wang, He; Zhang, Wentai; Chen, Yi-Hao; Feng, Tianshun; Wang, Shousen; Fang, Yi

doi:10.3389/fendo.2023.1089190

Cited by 3 publications

(1 citation statement)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, NTIS has been reported to complicate the course of the diseases in patients admitted to the ICU because of COVID-19 [431][432][433][434]. The relationship between thyroid function and COVID-19 was recently examined in a systematic review of studies performed on a total of more than 5800 patients [435]. This systematic review confirmed that thyroid hormone levels, especially FT3 levels, were reduced in patients with COVID-19, compared to the healthy cohort, and this alteration was more evident in severe COVID-19 patients with pneumonia compared to those without pneumonia, indicating that decreased FT3 levels have clinical significance for the prognosis of this condition.…”

Section: Frailty and The Low T3 Syndromementioning

confidence: 99%

To Be Frail or Not to Be Frail: This Is the Question—A Critical Narrative Review of Frailty

Sciacchitano,

Carola,

Nicolais

et al. 2024

JCM

View full text Add to dashboard Cite

Many factors have contributed to rendering frailty an emerging, relevant, and very popular concept. First, many pandemics that have affected humanity in history, including COVID-19, most recently, have had more severe effects on frail people compared to non-frail ones. Second, the increase in human life expectancy observed in many developed countries, including Italy has led to a rise in the percentage of the older population that is more likely to be frail, which is why frailty is much a more common concern among geriatricians compared to other the various health-care professionals. Third, the stratification of people according to the occurrence and the degree of frailty allows healthcare decision makers to adequately plan for the allocation of available human professional and economic resources. Since frailty is considered to be fully preventable, there are relevant consequences in terms of potential benefits both in terms of the clinical outcome and healthcare costs. Frailty is becoming a popular, pervasive, and almost omnipresent concept in many different contexts, including clinical medicine, physical health, lifestyle behavior, mental health, health policy, and socio-economic planning sciences. The emergence of the new “science of frailty” has been recently acknowledged. However, there is still debate on the exact definition of frailty, the pathogenic mechanisms involved, the most appropriate method to assess frailty, and consequently, who should be considered frail. This narrative review aims to analyze frailty from many different aspects and points of view, with a special focus on the proposed pathogenic mechanisms, the various factors that have been considered in the assessment of frailty, and the emerging role of biomarkers in the early recognition of frailty, particularly on the role of mitochondria. According to the extensive literature on this topic, it is clear that frailty is a very complex syndrome, involving many different domains and affecting multiple physiological systems. Therefore, its management should be directed towards a comprehensive and multifaceted holistic approach and a personalized intervention strategy to slow down its progression or even to completely reverse the course of this condition.

show abstract

Section: Frailty and The Low T3 Syndromementioning

confidence: 99%

To Be Frail or Not to Be Frail: This Is the Question—A Critical Narrative Review of Frailty

Sciacchitano,

Carola,

Nicolais

et al. 2024

JCM

View full text Add to dashboard Cite

show abstract

Thyroid dysfunction in COVID-19

Lui,

Lee,

Woo

et al. 2024

Nat Rev Endocrinol

View full text Add to dashboard Cite

Association between thyroid function and prognosis of severe COVID-19 among patients with SARS-CoV-2 infection: a retrospective cohort study in China

Yang,

Qian,

et al. 2024

Front. Endocrinol.

View full text Add to dashboard Cite

ObjectiveThis study aims to examine the thyroid hormone profile and its association with severe coronavirus disease 2019 (COVID-19) in patients infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).MethodsThis retrospective cohort study enrolled patients admitted to a tertiary hospital due to SARS-CoV-2 infection between February 18 and May 18, 2022. Clinical data were collected retrospectively from the electronic medical record system. Based on the thyroid function, patients were divided into five groups: normal, non-thyroid illness syndrome (NTIS), hypothyroidism, thyrotoxicosis, and unclassified. The association between thyroid function and severe COVID-19 was detected using multivariable logistic regression and restricted cubic splines analysis.ResultsThis study included 3,161 patients, with 7.7% of them developing severe COVID-19. 44.9% of the patients had normal thyroid function, 36.5% had NTIS, 6.7% had hypothyroidism, and 1.0% had thyrotoxicosis on admission. After adjusting for age, sex, and relevant clinical characteristics, NTIS and hypothyroidism were associated with increased risks of severe COVID-19 (odds ratio [OR] 2.38, 95% confidence interval [CI] 1.59-3.56 and OR 2.29, 95% CI 1.23-4.26, respectively), compared to normal thyroid function group. Among patients with NTIS or hypothyroidism, higher levels of total triiodothyronine (TT3) are associated with lower risks of severe COVID-19 (OR 0.73, 95% CI 0.64-0.82, for every 0.1nmol/L increase in TT3 level).ConclusionThyroid hormone profiles of NTIS or hypothyroidism are associated with increased risks of severe COVID-19. The decreased level of TT3 correlated with the increased risk of severe COVID-19 in patients with NTIS or hypothyroidism.

show abstract

Thyroxine changes in COVID-19 pandemic: A systematic review and meta-analysis

Cited by 3 publications

References 73 publications

To Be Frail or Not to Be Frail: This Is the Question—A Critical Narrative Review of Frailty

To Be Frail or Not to Be Frail: This Is the Question—A Critical Narrative Review of Frailty

Thyroid dysfunction in COVID-19

Association between thyroid function and prognosis of severe COVID-19 among patients with SARS-CoV-2 infection: a retrospective cohort study in China

Contact Info

Product

Resources

About