THz enantiomers of drugs recognized by the polarization enhancement of gold nanoparticles on an asymmetric metasurface

Shi, Wei-Nan; Wang, Yi-Ming; Fan, Fei; Liu, Jia-Yue; Cheng, Jie-Rong; Wang, Xiang-Hui; Chang, Sheng-Jiang

doi:10.1039/d3nr01826a

Cited by 8 publications

(2 citation statements)

References 39 publications

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“…20 Sometimes, the CD is still not large enough, which needs the help of plasmonic enhancement by metallic nanoparticles. 18,21 Twisted stacking chiral metasurface is another potential way. 22,23 With the introduction of 3D outof-plane mirror symmetry-breaking, a coupled mode of superchiral field could be implemented.…”

Section: Introductionmentioning

confidence: 99%

“…Metasurfaces with bound states in the continuum (BIC) emerged recently as a new strategy to provide giant CD in the single-layer scheme, , the extremely small slant angles or the dimensional accuracy required are quite challenging for fabrication . Sometimes, the CD is still not large enough, which needs the help of plasmonic enhancement by metallic nanoparticles. , Twisted stacking chiral metasurface is another potential way. , With the introduction of 3D out-of-plane mirror symmetry-breaking, a coupled mode of superchiral field could be implemented. Several solutions were proposed to actually realize such multilayer metasurfaces.…”

Section: Introductionmentioning

confidence: 99%

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Automatically Aligned and Environment-Friendly Twisted Stacking Terahertz Chiral Metasurface with Giant Circular Dichroism for Rapid Biosensing

Wang,

Huang,

Liu

et al. 2024

ACS Appl. Mater. Interfaces

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Chiral metasurfaces are capable of generating a huge superchiral field, which has great potential in optoelectronics and biosensing. However, the conventional fabrication process suffers greatly from time consumption, high cost, and difficult multilayer alignment, which hinder its commercial application. Herein, we propose a twisted stacking carbon-based terahertz (THz) chiral metasurface (TCM) based on laser-induced graphene (LIG) technology. By repeating a two-step process of sticking a polyimide film, followed by laser direct writing, the two layers of the TCM are aligned automatically in the fabrication. Laser manufacturing also brings such high processing speed that a TCM with a size of 15 × 15 mm can be prepared in 60 s. In addition, due to the greater dissipation of LIG than that of metals in the THz band, a giant circular dichroism (CD) of +99.5 to −99.6% is experimentally realized. The THz biosensing of bovine serum albumin enhanced by the proposed TCMs is then demonstrated. A wide sensing range (0.5−50 mg mL −1 ) and a good sensitivity [ΔCD: 2.09% (mg mL −1 ) −1 , Δf: 0.0034 THz (mg mL −1 ) −1 ] are proved. This LIG-based TCM provides an environment-friendly platform for chiral research and has great application potential in rapid and low-cost commercial biosensing.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Automatically Aligned and Environment-Friendly Twisted Stacking Terahertz Chiral Metasurface with Giant Circular Dichroism for Rapid Biosensing

Wang,

Huang,

Liu

et al. 2024

ACS Appl. Mater. Interfaces

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Advances in Metasurface‐Based Terahertz Sensing

Zhao,

Zhang,

Liang

2024

Advanced Physics Research

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Terahertz (THz) technology has attracted significant attention because of its unique applications in biological/chemical sensing, medical imaging, non‐invasive detection, and high‐speed communication. Metasurfaces provide a dynamic platform for THz sensing applications, showcasing greater flexibility in design and the ability to optimize light‐matter interactions for specific target enhancements, which includes enhancing the intramolecular and intermolecular vibration modes of the target biological/chemical molecules, setting them apart from conventional approaches. This review focuses on recent THz metasurface sensing methods, including metasurfaces based on toroidal dipole and quasi‐bound states in the continuum to improve sensing sensitivity, nanomaterial‐assisted metasurfaces for specific recognition, and metasurfaces combined with microfluidic with reduce water absorption loss. Furthermore, the applications of THz metasurface sensing is reviewed, including detecting the concentration of biomolecules, cells, tissues, and microbes, THz biomolecular fingerprint absorption spectra recognition, and identifying chiral compounds using chiral and achiral metasurfaces. Finally, the prospects for the next generation of THz sensors are examined.

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Chiral-based optical and electrochemical biosensors: Synthesis, classification, mechanisms, nanostructures, and applications

Beyrami,

Golshan,

Kucińska-Lipka

et al. 2024

Chemical Engineering Journal

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THz enantiomers of drugs recognized by the polarization enhancement of gold nanoparticles on an asymmetric metasurface

Abstract: The recognition of chiral enantiomers by a metasurface was realized; both the detection sensitivity and precision were enhanced by gold nanoparticles.

Cited by 8 publications

References 39 publications

Automatically Aligned and Environment-Friendly Twisted Stacking Terahertz Chiral Metasurface with Giant Circular Dichroism for Rapid Biosensing

Automatically Aligned and Environment-Friendly Twisted Stacking Terahertz Chiral Metasurface with Giant Circular Dichroism for Rapid Biosensing

Advances in Metasurface‐Based Terahertz Sensing

Chiral-based optical and electrochemical biosensors: Synthesis, classification, mechanisms, nanostructures, and applications

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