Ti(III)-Catalyzed Anti-Markovnikov Reduction of Epoxides with Borohydride

Abstract

We have developed a Ti catalyst that carries out the anti-Markovnikov reduction of a wide range of epoxides; [BH 4 ] − is used as both the electron and the hydrogen atom source. It requires only mild conditions and accommodates a broad range of epoxide substrates. The Ti catalyst is readily available and is environmentally friendly.