Ti3C2 MXenes nanosheets catalyzed highly efficient electrogenerated chemiluminescence biosensor for the detection of exosomes

Zhang, Huixin; Wang, Zonghua; Zhang, Qiuxia; Wang, Feng; Liu, Yang

doi:10.1016/j.bios.2018.10.016

Cited by 282 publications

(144 citation statements)

References 53 publications

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“…The general formula of MXene is M n + 1 X n or M n + 1 X n T x (n = 1, 2, or 3), where Mi sa ne arly transition metal atom (e.g.,S c, Ti,V , Cr,Z r, Nb, Mo, or W), Xi sacarbon and/oran itrogen atom, and T x is the terminating functional group (e.g., ÀOH, ÀO, or ÀF). [5,9] In 2011, Gogotsi andc o-workers [10] reportedageneral synthesis methodt os electively etch Al ayers from the layer structure parentM AX phases (i.e.,M= Sc, Ti,V ,C r, Zr,N b, Mo, or W; A = group IIIA or IVAe lement;X = C, N) to prepare MXenes (e.g.,T i 2 C, [11][12][13] Ti 3 C 2 , [12,[14][15][16] and Nb 4 C 3 [17,18] ); the interlayer MÀAb onds and interatomic AÀAb onds are much weaker than the MÀXb onds in MAX phases. [9,19] Interestingly, the uniquei n-plane anisotropic layer structure and metallic nature endow MXenes with extraordinary physicala nd chemical properties in terms of high electronic conductivities, adjustable band gaps, and af unctionalized redox-active surface [10,20,21] that providemore electrochemically reactive interfaces and facilitatet he in-plane ion-/electron-transport kinetics in energy-storage and -conversion applications.…”

Section: Introductionmentioning

confidence: 95%

2 D MXene‐based Energy Storage Materials: Interfacial Structure Design and Functionalization

Fang

Chen

et al. 2019

ChemSusChem

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Transition metal carbides and/or nitrides (MXenes), a burgeoning group of 2 D layer‐structure compounds, have multiple merits, such as high electrical conductivity, tunable layer structure, small band gap, and functionalized redox‐active surface, and are receiving significant attention as one of the most promising class of energy storage materials. The synthesis methods, structural configuration, and surface chemistry of MXenes directly influence their performance. This Minireview focuses on interfacial structure design and functionalization of MXenes and MXene‐based energy storage materials and the effect of structural configuration and surface chemistry on their electrochemical performance. Additionally, the structure–property relationships between interfacial structure, functional group, interlayer spacing, and the corresponding energy storage performance are summarized in detail. Finally, light is shed on the perspectives for the future research on advanced MXene‐based energy storage materials including scientific and technical challenges.

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Section: Introductionmentioning

confidence: 95%

2 D MXene‐based Energy Storage Materials: Interfacial Structure Design and Functionalization

Fang

Chen

et al. 2019

ChemSusChem

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“…While the basic configurations leading to successful construction of enzymatic MXene‐based electrochemical biosensors are well‐established, integration of MXene into electrochemical affinity‐based biosensors is not that trivial. We envisage that MXene will find its niche to design robust electrochemical interfaces , but also various types of nanoprobes with immobilized enzymes, catalytic nanoparticles for signal amplification strategies working in sandwich configurations . Moreover, it is anticipated that especially hybrid nanoparticles composed of MXene nanosheets with deposited magnetic (nano)particles will play a dominant role in selective enrichment of various analytes from complex samples based on affinity interactions.…”

Section: Discussionmentioning

confidence: 99%

“…Sensitive detection of exosomes was performed using a biosensor based on electrogenerated chemiluminescence . In the 1 st step, MXene was modified by polyethyleneimine (PEI) by electrostatic interactions between negatively charged MXene (ζ∼−50 mV) and positively charged PEI (ζ∼+55 mV) to make MXene/PEI nanocomposite positively charged (ζ∼80 mV).…”

Section: Application Of Mxene In Biosensingmentioning

confidence: 99%

“…Exosomes released from MCF‐7 cell line were detected in the concentration window from 500 to 5×10 6 particles per μL with LOD of 125 particles per μL, which was over 100 times lower than that of conventional ELISA method. The biosensor showed excellent performance by analysis of spiked serum samples with recovery indexes from 95 % to 104 % . The next study from the same group indicates that besides CD63 and EpCAM, another proteins present on the surface of exosome can be targeted by DNA aptamers including PSMA and PTK‐7 .…”

Section: Application Of Mxene In Biosensingmentioning

confidence: 99%

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2D MXenes as Perspective Immobilization Platforms for Design of Electrochemical Nanobiosensors

et al. 2019

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MXenes are a new group of 2D nanomaterials with fascinating properties including high electrical conductivity, hydrophilic nature, easily tunable structure and high surface area. This is why MXene modified interfaces are extremely promising for the preparation of sensitive electrochemical biosensors. While there are numerous reports on MXene‐based enzymatic biosensors for detection of a wide range of analytes, application of MXene for construction of affinity biosensors is in its infancy. The review article summarizes current state‐of the‐art in the field with a focus on MXene modifications needed for construction of robust and high performance MXene electrochemical biosensors.

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“…A biosensor based on the application of MXene and electrogenerated chemiluminescence (ECL) was developed for the sensitive detection of exosomes . First, MXene (ζ∼−50 mV) was modified by polyethyleneimine (PEI) (ζ∼+55 mV) through electrostatic interactions to prepare an MXene/PEI nanocomposite (ζ∼80 mV).…”

Section: Electrochemical Exosome Biosensingmentioning

confidence: 99%

Exosomes as a Source of Cancer Biomarkers: Advances in Electrochemical Biosensing of Exosomes

et al. 2020

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Exosomes are naturally produced biological nanoparticles secreted by cells into body fluids and responsible for intercellular communication. Exosomes can also carry cargo affecting neighbouring cells and forming pre‐metastatic niches. Hence, exosomes are behind localised tumour development, progression, but also the induction of distant tumours forming metastasis. A substantially higher cellular activity of tumour cells results in the production of a greater number of exosomes than in normal, healthy cells. Therefore, the number of exosomes present in body fluids can serve as a good diagnostic biomarker in itself, besides the presence of other tumour biomarkers, which can be substantially enriched in exosomes compared to parental cells. This review comprehensively summarises the development of electrochemical biosensors for the detection of exosome levels, exosome‐derived cancer biomarkers in cell lines and serum samples for the better diagnosis of various cancer types. The review provides information on the design and analytical parameters of such biosensors. The clinical utility of the level of exosomes or exosome‐derived biomarkers is also provided.

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Ti3C2 MXenes nanosheets catalyzed highly efficient electrogenerated chemiluminescence biosensor for the detection of exosomes

Cited by 282 publications

References 53 publications

2 D MXene‐based Energy Storage Materials: Interfacial Structure Design and Functionalization

2 D MXene‐based Energy Storage Materials: Interfacial Structure Design and Functionalization

2D MXenes as Perspective Immobilization Platforms for Design of Electrochemical Nanobiosensors

Exosomes as a Source of Cancer Biomarkers: Advances in Electrochemical Biosensing of Exosomes

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