Tiamulin and semduramicin: effects of simultaneous administration on performance and health of growing broiler chickens

Abstract

The pleuromutilin antibiotic tiamulin (TIA) is known to produce a variety of negative interactive effects when it is administered in combination with several anticoccidial ionophores. A 35-d growth study was performed in cages to evaluate the compatibility of TIA when it was administered concurrently with the poly-ether ionophore anticoccidial semduramicin (SEM). Tiamulin and SEM, both alone and in combination, were administered to 10 replicates of female broilers arranged in a completely randomized block design. Tiamulin was administered in drinking water (250 mg of TIA/kg of water) from d 15 through 19 of the study, whereas SEM was incorporated in feed (25 mg/kg) from placement to the conclusion of the test. Water consumption was determined during the period of concurrent administration of the drugs and weekly measurements of feed intake and bird performance were recorded. In addition, hematocrit, blood cell counts, serum protein, albumin, glucose, uric acid, electrolytes, and activities of several enzymes were determined from blood samples taken at d 35. Results indicated that simultaneous administration of TIA and SEM during the third week of the trial reduced water and feed intake resulting in a temporary growth depression. Feed efficiency was transiently affected during the period of coadministration. However, during the fourth week of the test, negative effects in body weight were not observed for any treatment and feed conversion improved for birds concurrently receiving TIA + SEM. By the termination of the experiment, no adverse effects were observed in final performance for any treatment. Histopathological and hematological parameters were unaffected by treatment at d 35 of the test. These results demonstrated that simultaneous administration of TIA and SEM produced only temporary impairments of water and feed consumption that transiently influenced performance. Neither mortality nor long-term effects on performance variables occurred in broilers.

Scientific Opinion on safety and efficacy of Cygro® 10G (maduramicin ammonium α) for chickens for fattening

“…The severity of adverse effects varies depending on the ionophore itself, reaching from increased mortality to only transient performance depression (Badiola, et al, 1994;Schuhmacher, et al, 2006). Badiola (1994) studied the compatibility of maduramicin ammonium (5 mg/kg feed) with tiamulin (270 mg/L drinking water from day 28 to 31) for 52 days.…”

Postantibiotic effects and postantibiotic sub-MIC effects of tilmicosin, erythromycin and tiamulin on erythromycin-resistant Streptococcus suis

“…Tilmicosin is a new macrolide antibiotic synthetically derived from tylosin, which is specially used in veterinary medicine (10,15). Tiamulin was evaluated with tilmicosin because it has similar antimicrobial mechanism with macrolide and is commonly used to treat infections in swine and poultry (3,5,13,27). In this study, the MIC and MBC results in Table 1 showed that tilmicosin and tiamulin…”

Compatibility of a Combination of Tiamulin plus Chlortetracycline with Salinomycin in Feed During a Long-Term Co-Administration in Broilers

“…All studies show that as the TIA level is increased to 50 ppm that there is a drop in growth rate. The growth retardation in TIA groups, which may be accompanied by a drop in feed intake, might be a consequence of depressed water intake (Schuhmacher et al, 2006). In the trials in which there is an artificial M. gallisepticum challenge, the depression in weight gain caused by the 50 ppm TIA is masked by the drop in weight gain caused by the infection in the 60 ppm SAL controls.…”