Tianeptine’s Obscured Withdrawal, Presentation, and Treatment

Abstract

The misuse of over-the-counter supplements containing the drug tianeptine poses significant public health concerns, as evidenced by a rise in Poison Control calls and social media discussions regarding its adverse effects. This case report highlights a 67-year-old Caucasian male presenting with symptoms suggestive of tianeptine withdrawal after consuming excessive doses of the supplements daily and their abrupt cessation 12 hours prior to arrival. Despite stable vitals, the patient exhibited anticholinergic toxidrome manifestations, necessitating supportive care and monitoring for acute intoxication. The patient's symptoms resolved, and he was discharged after two days in the hospital. Differential diagnosis complexities underscore the need for enhanced screening protocols and tailored treatment strategies. The discussion emphasizes the importance of prompt identification and management of tianeptine-related complications and calls for heightened awareness among healthcare providers.