Tianma Gouteng Decoction combined with Qiju Dihuang Pill for the treatment of essential hypertension

Abstract

Background: Essential hypertension is one of the risk factors of cardiovascular and cerebrovascular diseases, which can cause target organ damage such as heart, brain and kidney, and has extremely high disability rate and death rate. With the development of economy and society, the prevalence rate of hypertension in China has increased rapidly from 9.8% in the 1980s to over 30% in the 21st century. According to the data published in “China Cardiovascular Disease Report 2018,” China currently has 245 million hypertension patients. Comprehensive prevention and treatment of hypertension has become one of the major public health problems in China. The clinical practice and theoretical innovation of traditional Chinese medicine in the prevention and treatment of hypertension have been carried out for decades. Relevant literature points out that Tianma Gouteng Decoction combined with Qiju Dihuang Pill has ideal effect in the treatment of primary hypertension. However, most of the literatures are small sample studies, with uneven quality and clinical evidence, and lack of evidence-based medical evidence for clinical efficacy. Therefore, this study makes further meta-analysis of Tianma Gouteng Decoction combined with Qiju Dihuang Pill in the treatment of primary hypertension, with a view to providing evidence-based medical evidence for the treatment of primary hypertension. Methods: We will search 3 foreign electronic databases (Cochrane Library, Embase, PubMed) and 4 Chinese electronic databases (China National Knowledge Infrastructure, WangFang Database, Chinese Biomedical Literature Database, and Chinese Scientific Journal Database) to collect potential systematic reviews from their inceptions to February 2020. The language of publication is limited to Chinese or English. First, the quality of randomized controlled trials documents included in this study was evaluated by using the improved Jadad scoring scale. Then, the 2 researchers conducted the evaluation independently according to Cochrane bias risk tools. The evidence level of the results will be evaluated by using the recommended evaluation, development and evaluation grading of recommendations assessment, development, and evaluation method. Statistical analysis will be conducted using Revman 5.3. Results: The results of this study will be published in a peer-reviewed journal. Conclusions: The conclusion of this study will provide evidence for the efficacy of Tianma Gouteng Decoction combined with Qiju Dihuang Pills in the treatment of primary hypertension due to the efficacy of western medicine alone in treating primary hypertension. Registration number PROSPERO: INPLASY202050088.

A Meta-analysis of Tianma Gouteng Decoction Combined with Qiju Dihuang Pills in the Treatment of Essential Hypertension

“…Into 23 articles, 1 [6] to research carried out in accordance with the "law of the double chromospheres" grouping, 1 study [21] shall be carried out in accordance with the "coin" grouping, 1 study [26] shall be carried out in accordance with the "lottery law" group, 2 study [18,25] shall be carried out in accordance with the "order" in hospital group, 2 study [10,19] according to the "admission number even method" grouping, 3 study [11,13,22] in accordance with the "random number table method", 5 study [9,14,20,23,24] to research carried out in accordance with the "treatment" group, eight studies [7, 8, 12, 15-17, 27, 28] only mentioned "randomization" without specifying specific methods, and did not mention the literature allocation concealment scheme or the use of blind method. The result of bias risk is shown in Figure 2.…”

“…00001], as shown in Figure 3. There were 15 studies comparing Traditional Chinese medicine with western medicine [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28], reporting the total clinical efficacy, including 1,452 patients. The differences in meta analysis results were statistically significant [OR=9.73, 95%CI (5.…”

“…00001], as shown in Figure 5. There were 15 studies comparing Chinese and Western medicines [13][14][15][17][18][19][20][21][22][23][24][25][26][27][28], in which patients' systolic blood pressure was reported and 1,556 patients were included. Meta analysis results showed statistically significant differences [SMD =-2.48, 95%CI (-3.21, -1.75), P<0.00001], suggesting that the combination of Tianma gouteng decoction combined with Qiju dihuang Pills in the treatment of EH can significantly reduce the systolic blood pressure level in EH patients.…”

“…00001], as shown in Figure 7. A total of 15 studies [13][14][15][17][18][19][20][21][22][23][24][25][26][27][28] comparing Traditional Chinese medicine with western medicine reported diastolic blood pressure in 1,556 patients, and the Meta analysis results showed statistically significant differences [SMD =-1.64, 95%CI (-2.02, -1.26)] (Z=6.27, P<0.00001), as shown in Figure 8. It suggests that the diastolic blood pressure of EH patients can be significantly reduced by the treatment of EH via Tianma gouteng decoction combined with Qiju dihuang Pills.…”

Efficacy of felodipine and enalapril in the treatment of essential hypertension with coronary artery disease and the effect on levels of Salusin-β, Apelin, and PON1 gene expression in patients

“…Hypertension and coronary heart disease are both relatively common chronic clinical conditions, with a high prevalence especially in the elderly population (1). Hypertension can be divided into two types, primary and secondary, of which primary hypertension is more common, and patients with primary hypertension are prone to coronary heart disease and other diseases, causing a great impact on the quality of life of patients (2). Felodipine is a calcium antagonist that dilates the small arteries of patients, thus effectively lowering their blood pressure levels, but the effect of this drug alone is limited and is usually used in combination with other drugs (3).…”