2023
DOI: 10.1016/j.jep.2023.116838
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Tiaogan Jiejiu Tongluo Formula attenuated alcohol-induced chronic liver injury by regulating lipid metabolism in rats

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Cited by 14 publications
(6 citation statements)
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“…Certain medications have been demonstrated to improve liver injury by increasing FXR expression. 13,14 FXR activation significantly reduced liver damage and inhibited the production of inflammatory cytokines. 15 A prior investigation has indicated that FXR levels in the liver showed an inverse correlation with the extent of NLRP3 inflammasome activation in individuals with hepatitis B virus-related liver failure or nonalcoholic fatty liver disease and in mice with liver injury.…”
Section: Discussionmentioning
confidence: 94%
See 1 more Smart Citation
“…Certain medications have been demonstrated to improve liver injury by increasing FXR expression. 13,14 FXR activation significantly reduced liver damage and inhibited the production of inflammatory cytokines. 15 A prior investigation has indicated that FXR levels in the liver showed an inverse correlation with the extent of NLRP3 inflammasome activation in individuals with hepatitis B virus-related liver failure or nonalcoholic fatty liver disease and in mice with liver injury.…”
Section: Discussionmentioning
confidence: 94%
“…Mice in the control group received a gavage of saline, whereas mice in the bifendate, DMY-H, and DMY-L groups were administered the corresponding drugs by gavage for 8 weeks. 13 On day 56, mice were anesthetized by ether, and the blood was obtained by extirpating the eyeballs. Blood samples were centrifuged for 15 min to obtain serum (1000 ×g, 4 °C).…”
Section: Animal Experimentsmentioning
confidence: 99%
“…Furthermore, silibinin may directly bind to TFR1 to inhibit cellular iron uptake and maintain iron homeostasis in ethanol- and acetaldehyde-induced liver injury [ 118 ]. Both murine double minute X (MDMX)/peroxisome proliferator-activated receptor alpha (PPARα) pathway [ 120 ] and liver kinase B1 (LKB1)/AMP-activated protein kinaseα (AMPKα) signal axis [ 121 ] were shown to be associated with ferroptosis. For alcohol-induced liver injury, verbenalin [ 120 ] and Tiaogan Jiejiu Tongluo Formula [ 121 ] showed a certain therapeutic effect through inhibiting intracellular lipid peroxidation, which was regulated by the MDMX/PPARα pathway and LKB1/AMPKα signal axis, respectively.…”
Section: Nac Treat Liver Disease By Targeting Ferroptosismentioning
confidence: 99%
“…Both murine double minute X (MDMX)/peroxisome proliferator-activated receptor alpha (PPARα) pathway [ 120 ] and liver kinase B1 (LKB1)/AMP-activated protein kinaseα (AMPKα) signal axis [ 121 ] were shown to be associated with ferroptosis. For alcohol-induced liver injury, verbenalin [ 120 ] and Tiaogan Jiejiu Tongluo Formula [ 121 ] showed a certain therapeutic effect through inhibiting intracellular lipid peroxidation, which was regulated by the MDMX/PPARα pathway and LKB1/AMPKα signal axis, respectively. Melatonin, a hormone present in various organisms from algae to humans, is responsible for regulating circadian rhythms and is also an important endogenous antioxidant.…”
Section: Nac Treat Liver Disease By Targeting Ferroptosismentioning
confidence: 99%
“…For instance, Tiaogan Jiejiu Tongluo Formula, by lowering the activity of ADH and raising the activity of ALDH, accelerates the conversion of acetaldehyde to acetic acid, alleviates the accumulation of large amounts of acetaldehyde and chronic acetaldehyde poisoning, and reduces the chronic liver injury induced by alcohol in SD rats. 37 Besides, certain functional beverages such as soda water and jia duo bao herbal infusion can also mitigate acetaldehyde levels in the body through ADH inhibition and ALDH enhancement, thus alleviating alcohol-induced hangovers in Kunming mice and preventing liver injury. 38 Additionally, Electrolytic hydrogen water (EHW) demonstrates the ability to reduce intracellular acetaldehyde levels, suppress cellular reactive oxygen species (ROS) elevation, and prevent cell death by inhibiting ADH activity while increasing ALDH activity in HepG2 liver cells.…”
mentioning
confidence: 99%