Tibial dyschondroplasia – tools, new insights and future prospects

Pines, Mark; Hasdai, A.; Monsonego-Ornan, Efrat

doi:10.1079/wps200454

Cited by 48 publications

(35 citation statements)

References 60 publications

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“…TD remains an extremely common skeletal abnormality in commercial broiler chickens worldwide (Pines et al, 2005;Dinev et al, 2012;Genin et al, 2012). TD is described as one of the most prevalent leg weakness conditions seen in modern broilers (Yalçin et al, 2007), and lesions have been found to be present in 30% of broiler flock (Crespo and Shivaprasad, 2011;Shahzad et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

“…The latter effect can result in considerable concern and consequence for the broiler farmer under modern welfareaccredited production systems. Considerable economic losses have been attributed to TD (Pines et al, 2005). Reluctance to move can result in damage to the bird from other birds walking over them (scratching possibly leading to cellulitis) or reduction in growth rate due to reduced access to feeders (Wideman, 2016).…”

Section: Introductionmentioning

confidence: 99%

“…A simple solution to prevent the disease has not been found (Pines et al, 2005). Many factors have been incriminated in the occurrence of TD, including genetic predisposition, an inappropriate calcium : phosphorus ratio in feed (i.e.…”

Section: Introductionmentioning

confidence: 99%

“…Experimentally, TD has been induced by thiram treatment but the mechanisms involved in these studies may differ from the condition observed in the field (Orth and Cook, 1994). The exact mechanism behind the development of TD remains unknown (Pines et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

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Earlier hatching time predisposes Cobb broiler chickens to tibial dyschondroplasia

Groves

Muir

2017

Animal

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Fertile eggs from Cobb 500 broiler breeder hens were incubated to provide low starting egg shell temperatures (EST; 36.9°C to 37.3°C) which were gradually increased to 37.8°C during the first 7 to 15 days of incubation compared with eggs incubated with a constant EST of 37.8°C (standard conditions) over the first 18 days of incubation. Time of individual chick hatching (measured at 6 h intervals from 468 h of incubation), chick weight, chick length and yolk weight were measured at take-off and BW was measured at 7, 14, 28, 34 and 42 days of age. Male birds at 34 and 42 days of age were assessed for their ability to remain standing in a latency-to-lie test. At 34 and 42 days, male birds were examined for leg symmetry, foot pad dermatitis, hock bruising and scored (scale 0 to 4, where 0 = no lesion and 4 = lesions extending completely across the tibial growth plate) for tibial dyschondroplasia (TD) lesions. The lower EST profiles caused chicks to hatch later than those incubated under the standard EST profile. Chicks which hatched at ⩽498 h incubation grew faster over the first 7 days than those that hatched later. There were significantly more birds (only males were studied) that hatched from the lower EST profiles with TD scores of 0 and 1 and fewer with score 4 at 34 days than those hatched under the standard profile. Male birds at 34 days with TD lesions ⩾3 stood for significantly shorter times than males with TD scores ⩽2. Moreover, male birds at 34 and 42 days with TD lesion scores of ⩾3 hatched significantly earlier and grew significantly faster over the first 2 weeks of age than did male birds with TD scores ⩽2. It appears possible to decrease the severity and prevalence of TD in the Cobb 500 broiler by ensuring that the birds do not hatch before 498 h of incubation.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Earlier hatching time predisposes Cobb broiler chickens to tibial dyschondroplasia

Groves

Muir

2017

Animal

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“…It leads to enormous economic losses worldwide and to animal welfare problems (Pines et al, 2005). Tibial dyschondroplasia is characterized by the formation of a lesion composed of non-vascularized, non-mineralized cartilage that extends from the epiphyseal growth plate into the metaphysic (Leach and Nesheim, 1965).…”

Section: Introductionmentioning

confidence: 99%

Effect of different vitamin D3 metabolites on intestinal calcium homeostasis-related gene expression in broiler chickens

et al. 2018

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-The purpose of this study was to investigate the effects of vitamin D 3 metabolites 1α-hydroxycholecalciferol (1α(OH)D 3 ), 25-hydroxycholecalciferol (25(OH) 2 D 3 ), and 1,25-dihydroxycholecalciferol (1,25(OH) 2 D 3 ) on growth performance, bone quality, and intestinal calcium homeostasis-related gene expression in broiler chickens. One-day-old broilers were fed a basal diet and basal diet containing different vitamin D 3 metabolites. The body weight, feed intake, and feed conversion ratio in control and experimental broilers were measured to assess the growth performance, mineral levels, and bone breaking strength. The duodenum was used to assess calcium homeostasis-related gene expressions by quantitative reverse transcription-PCR. No statistically significant difference was found in growth performance, mineral deposition, or bone breaking strength in broiler chickens after three weeks feeding with vitamin D 3 . However, supplementation of vitamin D 3 metabolites tended to improve feed conversion rate, bone mineral deposition, and breaking strength in broiler chickens. The results demonstrated that vitamin D 3 metabolites significantly upregulated calcium homeostasis-related genes, including calbindin, β-glucuronidase, TRPV6, and Na/Pi IIb cotransporter, mRNA levels after 12 h of feeding. The vitamin D 3 metabolite 1,25(OH) 2 D 3 was the most effective at regulating calcium homeostasis-associated gene expression after 6 h of feeding. Dietary vitamin D3 metabolites may alleviate the development of TD in broiler chickens and these effects probably occur through regulation of intestinal calcium homeostasis-related gene expression.

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Poultry Bone Development and Bone Disorders

Pines

Reshef

2015

Sturkie's Avian Physiology

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Tibial dyschondroplasia – tools, new insights and future prospects

Cited by 48 publications

References 60 publications

Earlier hatching time predisposes Cobb broiler chickens to tibial dyschondroplasia

Earlier hatching time predisposes Cobb broiler chickens to tibial dyschondroplasia

Effect of different vitamin D3 metabolites on intestinal calcium homeostasis-related gene expression in broiler chickens

Poultry Bone Development and Bone Disorders

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