“…The biological actions of tibolone are mediated through the metabolites of tibolone (3 -OH-tibolone, 3 -OH-tibolone, and Δ 4 -isomer) by binding estrogen or progesterone receptors in multiple target tissues and organs (brain, bone, breast, and endometrium). Based on several randomized trials, tibolone has shown comparable effects with traditional estrogen therapy (ET)/HT on relieving vasomotor symptoms/ genital atrophy, improving the quality of life, and preventing bone loss in postmenopausal women [81][82][83][84]. Currently 4 studies have shown the effects of tibolone on BW or body composition in postmenopausal women.…”