Ticagrelor improves systemic immune-inflammation index in acute coronary syndrome patients

Adalı, Mehmet Koray; Buber, Ipek; Kilic, Oguz; Turkoz, Anil; Yılmaz, Samet

doi:10.1080/00015385.2021.1973770

Cited by 20 publications

(12 citation statements)

References 25 publications

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“…On the other hand, systemic immune-inflammation index (SII) is a novel marker of inflammation and is related to cardiovascular disease involving mechanisms such as atherosclerosis and inflammation [9][10][11][12], but the relationship with CSFP is unclear. Therefore, in view of the pathogenesis of CSFP and the significance of SII in cardiovascular disease, the aim of this study was to evaluate the relationship between increased SII and CSFP.…”

Section: Introductionmentioning

confidence: 99%

Relationship between increased systemic immune-inflammation index and coronary slow flow phenomenon

Dai

Kong

Zhang

et al. 2022

BMC Cardiovasc Disord

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Background Systemic immune-inflammation index (SII, platelet × neutrophil/lymphocyte ratio), a new marker of inflammation, is associated with adverse cardiovascular events, but its relationship with coronary slow flow phenomenon (CSFP) is unclear. Therefore, we aimed to investigate the relationship between SII and CSFP. Methods We enrolled consecutive patients who presented with chest pain, with normal/near-normal coronary angiography findings (n = 89 as CSFP group; n = 167 as control group). The baseline characteristics, laboratory parameters and angiographic characteristics of the two groups were compared. Results SII levels were significantly higher in the CSFP group than in the control group (409.7 ± 17.7 vs. 396.7 ± 12.7, p < 0.001). A significant positive correlation between SII and the mean thrombolysis in myocardial infarction frame count (mTFC) was found (r = 0.624, p < 0.001). SII increased with the number of coronary arteries involved in CSFP. In multivariate logistic regression analysis, SII/10 was an independent predictor of CSFP (odds ratio: 1.739, p < 0.001). In addition, the SII level > 404.29 was a predictor of CSFP with 67.4% sensitivity and 71.9% specificity. Conclusions SII can predict the occurrence of CSFP.

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Section: Introductionmentioning

confidence: 99%

Relationship between increased systemic immune-inflammation index and coronary slow flow phenomenon

Dai

Kong

Zhang

et al. 2022

BMC Cardiovasc Disord

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“…If so, the PLR biomarker could be used to measure the degree of adherence to therapeutic recommendations or the individual variability of response to the intervention. Single scientific reports show, for example, that ticagrelor may improve the parameters of inflammation compared to another antiplatelet drug, i.e., clopidogrel [51]. Finally, the cost-effectiveness of the PLR has not been defined.…”

Section: Discussionmentioning

confidence: 99%

The Prognostic Role of Platelet-to-Lymphocyte Ratio in Acute Coronary Syndromes: A Systematic Review and Meta-Analysis

Pruc,

Peacock,

Rafique

et al. 2023

JCM

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This study aimed to investigate the potential prognostic role of the platelet-to-lymphocyte (PLR) ratio in patients presenting with suspected acute coronary syndromes (ACS). A systematic search of PubMed Central, Scopus, EMBASE, and the Cochrane Library from conception through 20 August 2023 was conducted. We used odds ratios (OR) as the effect measure with 95% confidence intervals (CIs) for dichotomous data and mean differences (MD) with a 95% CI for continuous data. If I2 was less than 50% or the p value of the Q tests was less than 0.05, a random synthesis analysis was conducted. Otherwise, a fixed pooled meta-analysis was performed. Nineteen studies fulfilled the eligibility criteria and were included in the meta-analysis. PLR was higher in MACE-positive (164.0 ± 68.6) than MACE-negative patients (115.3 ± 36.9; MD = 40.14; 95% CI: 22.76 to 57.52; p < 0.001). Pooled analysis showed that PLR was higher in AMI patients who died (183.3 ± 30.3), compared to survivors (126.2 ± 16.8; MD = 39.07; 95% CI: 13.30 to 64.84; p = 0.003). It was also higher in the ACS vs. control group (168.2 ± 81.1 vs. 131.9 ± 37.7; MD = 39.01; 95% CI: 2.81 to 75.21; p = 0.03), STEMI vs. NSTEMI cohort (165.5 ± 92.7 vs. 159.5 ± 87.8; MD = 5.98; 95% CI: −15.09 to 27.04; p = 0.58), and MI vs. UAP populations (162.4 ± 90.0 vs. 128.2 ± 64.9; MD = 18.28; 95% CI: −8.16 to 44.71; p = 0.18). Overall, our findings confirmed the potential prognostic role of the plate-let-to-lymphocyte (PLR) ratio in patients presenting with suspected acute coronary syndromes (ACS). Its use as a risk stratification tool should be examined prospectively to define its capability for evaluation in cardiovascular patients.

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“…Those with a lower ratio of omega-6 to omega-3 fatty acids had lower SII and NLR values, which resulted from an anti-inflammatory diet. Adali and collaborators underlined the significance of coronary artery disease pharmacotherapy [ 71 ]. Patients treated with ticagrelor had lower SII, NLR, and PLR values than clopidogrel-treated patients.…”

Section: Discussionmentioning

confidence: 99%

Neutrophil Counts, Neutrophil-to-Lymphocyte Ratio, and Systemic Inflammatory Response Index (SIRI) Predict Mortality after Off-Pump Coronary Artery Bypass Surgery

Urbanowicz

Michalak

Olasińska-Wiśniewska

et al. 2022

Cells

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Background: Several perioperative inflammatory markers are postulated to be significant factors for long-term survival after off-pump coronary artery bypass surgery (OPCAB). Hematological parameters, whether single or combined as indices, provide higher predictive values. Methods: The study group comprised 538 consecutive patients (125 (23%) females and 413 (77%) males) with a mean age of 65 +/− 9 years, who underwent OPCAB with a mean follow-up time of 4.7 +/− 1.7 years. This single-center retrospective analysis included perioperative inflammatory markers such as the neutrophil-to-lymphocyte ratio (NLR), systemic inflammatory response index (SIRI), aggregate index of systemic inflammation (AISI), and systemic inflammatory index (SII). Results: Multivariable analysis identified levels of neutrophils above 4.3 × 109/L (HR 13.44, 95% CI 1.05–3.68, p = 0.037), values of SIRI above 5.4 (HR 0.29, 95% CI 0.09–0.92, p = 0.036) and values of NLR above 3.5 (HR 2.21, 95% CI 1.48–3.32, p < 0.001) as being significant predictors of long-term mortality. The multifactorial models revealed the possibility of strong prediction by combining preoperative factors (COPD, stroke, PAD, and preoperative PLR) and postoperative neutrophil counts (p = 0.0136) or NLR (p = 0.0136) or SIRI (p = 0.0136). Conclusions: Among the postoperative inflammatory indices, the levels of neutrophils, NLR, and SIRI are the most prominent markers for long-term survival after off-pump coronary artery bypass surgery, when combined with preoperative characteristics.

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Ticagrelor improves systemic immune-inflammation index in acute coronary syndrome patients

Cited by 20 publications

References 25 publications

Relationship between increased systemic immune-inflammation index and coronary slow flow phenomenon

Relationship between increased systemic immune-inflammation index and coronary slow flow phenomenon

The Prognostic Role of Platelet-to-Lymphocyte Ratio in Acute Coronary Syndromes: A Systematic Review and Meta-Analysis

Neutrophil Counts, Neutrophil-to-Lymphocyte Ratio, and Systemic Inflammatory Response Index (SIRI) Predict Mortality after Off-Pump Coronary Artery Bypass Surgery

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