Sensitization to alpha-gal as a cause of idiopathic anaphylaxisTo the Editor,The incidence of anaphylaxis continues to rise globally based on hospital data from Europe (Sweden), United States, Australia, Brazil and some Asian (Japan) countries. [1][2][3][4] However, the incidence is likely to be higher due to misdiagnosis, misclassification, and underreporting 1 and because allergies and anaphylaxis are being neglected in developing countries due to other disease priorities. 5 In a large proportion of cases, after extensive evaluation, a trigger cannot be identified and are classified as 'idiopathic anaphylaxis' (IA).