Tick-Borne Zoonotic Bacteria in Ticks Collected from Central Spain

Toledo, Álvaro; Olmeda, A. Sonia; Escudero, Raquel; Jado, Isabel; Valcárcel, F.; Casado-Nistal, M. A.; Rodríguez-Vargas, Manuela; Gil, Horacio; Anda, Pedro

doi:10.4269/ajtmh.2009.81.67

Cited by 90 publications

(53 citation statements)

References 63 publications

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“…The range of arthropod vectors connected with tularemia has expanded to include ticks [19,40,[53][54][55][56][57][58][59][60], mosquitoes [56,61], horse flies [56], fleas [62] and gamasid mites [3]. In Europe, much of the research on the role of arthropod vectors in the transmission of F. tularensis subsp.…”

Section: Tularemia In Vectorsmentioning

confidence: 99%

The status of tularemia in Europe in a one-health context: a review

et al. 2014

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SUMMARYThe bacterium Francisella tularensis causes the vector-borne zoonotic disease tularemia, and may infect a wide range of hosts including invertebrates, mammals and birds. Transmission to humans occurs through contact with infected animals or contaminated environments, or through arthropod vectors. Tularemia has a broad geographical distribution, and there is evidence which suggests local emergence or re-emergence of this disease in Europe. This review was developed to provide an update on the geographical distribution of F. tularensis in humans, wildlife, domestic animals and vector species, to identify potential public health hazards, and to characterize the epidemiology of tularemia in Europe. Information was collated on cases in humans, domestic animals and wildlife, and on reports of detection of the bacterium in arthropod vectors, from 38 European countries for the period 1992-2012. Multiple international databases on human and animal health were consulted, as well as published reports in the literature. Tularemia is a disease of complex epidemiology that is challenging to understand and therefore to control. Many aspects of this disease remain poorly understood. Better understanding is needed of the epidemiological role of animal hosts, potential vectors, mechanisms of maintenance in the different ecosystems, and routes of transmission of the disease.

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Section: Tularemia In Vectorsmentioning

confidence: 99%

The status of tularemia in Europe in a one-health context: a review

et al. 2014

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“…Though less common, this tick can also be found in other domestic animals, as well as in wild ungulates and small-medium sized mammals and sporadically, in humans (de la Fuente et al, 2004b;Mihalca et al, 2012;Psaroulaki et al, 2006;Santos-Silva et al, 2011;Satta et al, 2011;Walker et al, 2000). R. bursa has been described as being involved in the transmission of agents of the genus Anaplasma (de la Fuente et al, 2004a), Babesia (Altay et al, 2008;M'Ghirbi et al, 2010) Theileria (Garcia-Sanmartin et al, 2008), Rickettsia (Boudebouch et al, 2009;de Sousa et al, 2006;Ioannou et al, 2011;Toledo et al, 2009) among others, with a known impact on animal health. The main objective of this study was to provide up-dated information regarding the currently circulating pathogens in R. bursa and their phylogenetic characterization, in Portugal Mainland, for the future development and planning of effective tick control measures.…”

Section: Introductionmentioning

confidence: 99%

Detection and phylogenetic characterization of Theileria spp. and Anaplasma marginale in Rhipicephalus bursa in Portugal

Ferrolho

Antunes

Santos

et al. 2016

Ticks and Tick-borne Diseases

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a b s t r a c tTicks are obligatory blood-sucking arthropod (Acari:Ixodida) ectoparasites of domestic and wild animals as well as humans. The incidence of tick-borne diseases is rising worldwide, challenging our approach toward diagnosis, treatment and control options. Rhipicephalus bursa Canestrini and Fanzago, 1877, a two-host tick widely distributed in the Palearctic Mediterranean region, is considered a multi-host tick that can be commonly found on sheep, goats and cattle, and occasionally on horses, dogs, deer and humans. R. bursa is a species involved in the transmission of several tick-borne pathogens with a known impact on animal health and production. The aim of this study was to estimate R. bursa prevalence in Portugal Mainland and circulating pathogens in order to contribute to a better knowledge of the impact of this tick species. Anaplasma marginale and Theileria spp. were detected and classified using phylogenetic analysis. This is the first report of Theileria annulata and Theileria equi detection in R. bursa ticks feeding on cattle and horses, respectively, in Portugal. This study contributes toward the identification of currently circulating pathogens in this tick species as a prerequisite for developing future effective anti-tick control measures.

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“…Since then, other cases have been described in different countries (12)(13)(14)(15), including Spain (16)(17)(18). Although it is mainly associated with Hyalomma spp.…”

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confidence: 99%

Coinfection with “Rickettsia sibirica subsp. mongolotimonae” and Rickettsia conorii in a Human Patient: a Challenge for Molecular Diagnosis Tools

et al. 2015

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Rickettsioses are zoonoses transmitted by vectors. More than one agent can coexist in vectors. Although vectors may transmit more than one microorganism to humans, information on dual infections is scarce. We present a case of a patient with an atypical rickettsiosis diagnosis in whom two species of Rickettsia were detected. CASE REPORTA 46-year-old woman was admitted to Bellvitge University Hospital in May with fever (38°C) as well as a retroauricular adenopathy and a subsequent preauricular and lateral cervical adenopathy that had lasted for 10 days. On examination at admission, she was afebrile and she had a necrotic eschar on the scalp (tache noire), face swelling, and a rash on her upper extremities. Laboratory examination showed normal values, except for the presence of activated lymphocytes and increased levels of alanine aminotransferase/aspartate aminotransferase, lactate dehydrogenase, and gamma-glutamyl transpeptidase. Testing of the patient's serum for toxoplasma and cytomegalovirus were negative. She reported that she had a dog and she had observed ticks on it recently.Tick-borne lymphadenopathy (TIBOLA) (recently called scalp eschar and neck lymphadenopathy syndrome [SENLAT]) caused by Rickettsia slovaca was suspected. As a consequence, a regimen of doxycycline (100 mg every 12 h for 4 days) was prescribed. The patient's condition improved. She was discharged 5 days after admission. The patient underwent periodical clinical evaluations for 49 days until her symptoms resolved completely.At admission, an acute-phase serum sample, a blood sample, and a scalp eschar biopsy specimen were collected. Serum was evaluated by indirect immunofluorescence assay (IFA).Antibodies against Rickettsia conorii were tested for using a commercial antigen (R. conorii spot; bioMérieux, Marcy l'Étoile, France). Antibodies against R. slovaca were tested for using an R. slovaca antigen kindly provided by the Unité de Rickettsies, Marseille, France. IgG antibodies against R. conorii antigen (titer Ͼ 5,120) were detected, whereas the IFA using R. slovaca antigen was negative. As neither clinical nor epidemiological variables were typical of Mediterranean spotted fever (MSF, whose etiological agent is R. conorii), and IFA for R. slovaca was not positive, a more accurate diagnosis was carried out.DNA was obtained from the whole-blood sample, the scalp eschar biopsy specimen, and the liquid that contained the scalp eschar biopsy specimen. For this purpose, the MasterPure DNA purification kit (Epicentre, Madison, WI) was used. PCR assays targeting the rickettsial genes for the citrate synthase (gltA) and the outer membrane protein A (ompA), were performed (Table 1). For the citrate synthase gene (gltA), primer CS890r and a new primer (CS214_for), designed by our team, were used. For the ompA gene, a real-time PCR was designed by our team using a new pair of primers: Rr190.314 and Rr190.630. In addition, another pair of primers was used (Rr190.70 and Rr190.701). This set of primers amplifies a bigger fragment that includes the on...

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Tick-Borne Zoonotic Bacteria in Ticks Collected from Central Spain

Cited by 90 publications

References 63 publications

The status of tularemia in Europe in a one-health context: a review

The status of tularemia in Europe in a one-health context: a review

Detection and phylogenetic characterization of Theileria spp. and Anaplasma marginale in Rhipicephalus bursa in Portugal

Coinfection with “Rickettsia sibirica subsp. mongolotimonae” and Rickettsia conorii in a Human Patient: a Challenge for Molecular Diagnosis Tools

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