TiCl₄-mediated deoxygenative reduction of aromatic ketones to alkylarenes with ammonia borane

Abstract

A rapid and mild protocol for the exhaustive deoxygenation of various aromatic ketones to corresponding alkanes was described, which was mediated by TiCl4 and using ammonia borane (AB) as the...

A convenient and efficient synthesis of 3-benzofuryl-substituted phthalides

“…While the corresponding product was not detected, instead, the bis(benzofuryl)phthalide was obtained in high yeild (85%). Based on these results and also the literature precedents 23,[28][29][30][31] , we proposed that product 3a can be formed in two paths, and a plausible reaction pathway was proposed and depicted in Scheme 3. First, the Friedel-Crafts reaction of phthalaldehydic acid (2a) with 2-ethyl-1-benzofuran (1a) generates the intermediate II in the presence of FeCl3.…”