Ticlopidine-Induced Marrow Aplasia Treated with Cyclosporine

Abstract

A 50-year-old diabetic and hypertensive male patient is reported who had ticlopidine-induced marrow aplasia partially responsive to colony-stimulating factors and corticosteroids, but experienced complete recovery with cyclosporine. There is no consensus on the treatment of ticlopidine-induced marrow aplasia. Although many cases are reported to recover with colony-stimulating factors and corticosteroids, others are unresponsive or partially responsive. Our patient also did not completely respond to these medications, but was successfully treated with cyclosporine alone. Alone or in combination with corticosteroids, cyclosporine is an effective drug of choice for the resistant patients.

Severe neutropenia under clopidogrel treatment three weeks after coronary stenting

“…Severe neutropenia/a granulocytosis hasb een reportedf or thienopyridine derivatives, e.g.f or ticlopidine (5)(6)(7)(8)(9).The incidenceofneutropenia in patients treated with clopidogrel is much lowercompared to ticlopidine (7,8,10,11). However, recently the question wasraisedwhetherlarge multi-center clinical trials might have underestimated the incidenceo fn on-bleeding side effects of clopidogrel (9).…”