Tigecycline and inducible clindamycin resistance in clinical isolates of methicillin-resistant Staphylococcus aureus from Terengganu, Malaysia

Hamzah, Ainal Mardziah Che; Yeo, Chew Chieng; Puah, Suat Moi; Chua, Kek Heng; Rahman, Nor Iza A.; Abdullah, Fatimah Haslina; Othman, Norlela; Chew, C. H.

doi:10.1099/jmm.0.000993

Cited by 23 publications

(52 citation statements)

References 29 publications

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“…Amikacin resistance among MRSA isolates is generally in the upper range, with resistance rates mostly reported above 70% (Figure 2). However, one study on 66 MRSA isolates from a local teaching hospital in 2003, 2004, and 2007 reported amikacin resistance at a slightly lower range of 67.0% [16], whereas our more recent study involving 90 MRSA isolates obtained from HSNZ in 2016 and 2017 recorded an even lower rate, which was 12.2% [23].…”

Section: Antibiotic Susceptibility Profilesmentioning

confidence: 88%

“…Reports describing β-lactam resistance among Malaysian MSSA isolates are even scarcer. An early study reported an approximately 90% prevalence of resistance to penicillin and full susceptibility to oxacillin among 124 MSSA isolates from HUSM between March to August 2008 [19], while our recent study reported 84.4% and 5.5% prevalence of resistance to penicillin and oxacillin among 109 HSNZ MSSA isolates obtained in 2016 and 2017 [23].…”

Section: Antibiotic Susceptibility Profilesmentioning

confidence: 94%

“…Similar observations were also recorded among 175 MRSA isolates collected between 2011 and 2012 from Hospital Raja Permaisuri Bainun (HRPB), KPJ Ipoh Specialist Hospital (KPJ), and Gribbles Pathology Ipoh (GP) (located at Ipoh, the capital city of Perak state on the west coast of peninsular Malaysia [21]), as well as 67 MRSA strains obtained from adult patients (above 16 years old) with bacteremia in University of Malaya Medical Centre (UMMC) in 2013 [22]. Ninety MRSA isolates were obtained between 2016 and 2017 from Hospital Sultanah Nur Zahirah (HSNZ), located at Kuala Terengganu, the state capital of Terengganu on the east coast of peninsular Malaysia also showed full resistance to penicillin, oxacillin and cefoxitin [23].…”

Section: Antibiotic Susceptibility Profilesmentioning

confidence: 99%

“…Cefoperazone is rarely used in Malaysia and thus there is a scarcity of data reporting the rates of cefoperazone resistance among Malaysian MRSA isolates. To the best of our knowledge, our recent study on isolates from HSNZ is the only report of cefoperazone resistance among Malaysian MRSA isolates, with the prevalence of resistance recorded at 86.7% for the 2016–2017 isolates [23].…”

Section: Antibiotic Susceptibility Profilesmentioning

confidence: 99%

“…Data concerning clindamycin resistance among national MSSA isolates were only available from 2008 until 2014, where the resistance rates remained low throughout the years, i.e., below 3.0%, with the exception for our recent study of 109 HSNZ MSSA isolates from 2016 and 2017, where the prevalence of clindamycin resistance was slightly higher at 3.7% [23] (Figure 4).…”

Section: Antibiotic Susceptibility Profilesmentioning

confidence: 99%

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Staphylococcus aureus Infections in Malaysia: A Review of Antimicrobial Resistance and Characteristics of the Clinical Isolates, 1990–2017

et al. 2019

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Staphylococcus aureus is an important nosocomial pathogen and its multidrug resistant strains, particularly methicillin-resistant S. aureus (MRSA), poses a serious threat to public health due to its limited therapeutic options. The increasing MRSA resistance towards vancomycin, which is the current drug of last resort, gives a great challenge to the treatment and management of MRSA infections. While vancomycin resistance among Malaysian MRSA isolates has yet to be documented, a case of vancomycin resistant S. aureus has been reported in our neighboring country, Indonesia. In this review, we present the antimicrobial resistance profiles of S. aureus clinical isolates in Malaysia with data obtained from the Malaysian National Surveillance on Antimicrobial Resistance (NSAR) reports as well as various peer-reviewed published records spanning a period of nearly three decades (1990–2017). We also review the clonal types and characteristics of Malaysian S. aureus isolates, where hospital-associated (HA) MRSA isolates tend to carry staphylococcal cassette chromosome mec (SCCmec) type III and were of sequence type (ST)239, whereas community-associated (CA) isolates are mostly SCCmec type IV/V and ST30. More comprehensive surveillance data that include molecular epidemiological data would enable further in-depth understanding of Malaysian S. aureus isolates.

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Section: Antibiotic Susceptibility Profilesmentioning

confidence: 88%

Section: Antibiotic Susceptibility Profilesmentioning

confidence: 94%

Section: Antibiotic Susceptibility Profilesmentioning

confidence: 99%

Section: Antibiotic Susceptibility Profilesmentioning

confidence: 99%

Section: Antibiotic Susceptibility Profilesmentioning

confidence: 99%

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Staphylococcus aureus Infections in Malaysia: A Review of Antimicrobial Resistance and Characteristics of the Clinical Isolates, 1990–2017

et al. 2019

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Whole genome sequencing of methicillin-resistant Staphylococcus aureus clinical isolates from Terengganu, Malaysia, indicates the predominance of the EMRSA-15 (ST22-SCCmec IV) clone

Che Hamzah,

Chew,

Al-Trad

et al. 2024

Sci Rep

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Despite the importance of methicillin-resistant Staphylococcus aureus (MRSA) as a priority nosocomial pathogen, the genome sequences of Malaysian MRSA isolates are currently limited to a small pool of samples. Here, we present the genome sequence analyses of 88 clinical MRSA isolates obtained from the main tertiary hospital in Terengganu, Malaysia in 2016–2020, to obtain in-depth insights into their characteristics. The EMRSA-15 (ST22-SCCmec IV) clone of the clonal complex 22 (CC22) lineage was predominant with a total of 61 (69.3%) isolates. Earlier reports from other Malaysian hospitals indicated the predominance of the ST239 clone, but only two (2.3%) isolates were identified in this study. Two Indian-origin clones, the Bengal Bay clone ST772-SCCmec V (n = 2) and ST672 (n = 10) were also detected, with most of the ST672 isolates obtained in 2020 (n = 7). Two new STs were found, with one isolate each, and were designated ST7879 and ST7883. From the core genome phylogenetic tree, the HSNZ MRSA isolates could be grouped into seven clades. Antimicrobial phenotype-genotype concordance was high (> 95%), indicating the accuracy of WGS in predicting most resistances. Majority of the MRSA isolates were found to harbor more than 10 virulence genes, demonstrating their pathogenic nature.

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Inducible Clindamycin-Resistant Staphylococcus aureus Strains in Africa: A Systematic Review

Assefa

2022

International Journal of Microbiology

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Introduction. Excessive use of clindamycin enhances the acquisition of inducible clindamycin-resistant S. aureus strains, which is a significant health problem in Africa. The main objective of this review study was to determine the prevalence of inducible clindamycin resistance and related genes among S. aureus isolates in Africa. Methods. A qualitative systematic review was conducted on inducible clindamycin resistance among S. aureus isolates in Africa using electronic databases such as Google Scholar and PubMed. Articles published in English before 2021 were selected, and relevant data were extracted, collected, and analyzed. Results. In our search, 22 articles met the eligibility criteria for this review study. Of 3064 total S. aureus isolates, 605 had iMLSB phenotype. The overall prevalence of inducible clindamycin resistance in S. aureus isolates was 19.8% with a range of 2.9% to 44.0%. A high number of iMLSB phenotypes were observed in MRSA isolates (3.6–77.8%) than MSSA (0–58.8%). The overall prevalence of the iMLSB phenotype in MRSA strains was 26.8% (279/1041). The maximum peak prevalence of inducible clindamycin resistance among S. aureus isolates recorded in the continent was 44.0% in Egypt, followed by 35.8% in Libya and 33.3% in Uganda in 2017, 2007, and 2013, respectively. The highest prevalence of iMLSB phenotype in MRSA strains was reported in Egypt, 77.8%, followed by Nigeria, 75.0%, and Libya, 66.2%. Among the recovered drug-resistance genes, ermA, ermC, and msrA genes were commonly detected in Egypt with 67.9%, 70.0%, and 70.0% prevalence, respectively. Conclusion. This review highlights a higher inducible resistance of S. aureus, including MRSA strains to clindamycin in the continent. Regular screening of these strains, wise use of clindamycin, and molecular detection and genotyping of resistant genes are urgent.

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Tigecycline and inducible clindamycin resistance in clinical isolates of methicillin-resistant Staphylococcus aureus from Terengganu, Malaysia

Cited by 23 publications

References 29 publications

Staphylococcus aureus Infections in Malaysia: A Review of Antimicrobial Resistance and Characteristics of the Clinical Isolates, 1990–2017

Staphylococcus aureus Infections in Malaysia: A Review of Antimicrobial Resistance and Characteristics of the Clinical Isolates, 1990–2017

Whole genome sequencing of methicillin-resistant Staphylococcus aureus clinical isolates from Terengganu, Malaysia, indicates the predominance of the EMRSA-15 (ST22-SCCmec IV) clone

Inducible Clindamycin-Resistant Staphylococcus aureus Strains in Africa: A Systematic Review

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