Tigecycline application in a 3-month-old infant with multiple drug resistant Klebsiella pneumonia: a case report

Peng, Cheng; Jiang, Yi; Hou, Xinlin

doi:10.1186/s13099-018-0253-x

Cited by 6 publications

(2 citation statements)

References 18 publications

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“…In adults, there are many clinical trials with the use of tigecycline as a broad-spectrum antibiotic. In infants, only a few cases of tigecycline use have been reported because of side effects that include nausea, vomiting, diarrhea, acute pancreatitis, teeth discoloration, and neutrophil engraftment delay [3,11]. However, the recent data show that tigecycline may represent a considerable treatment option in life-threatening infectious complications in pediatric patients as a part of combination therapy.…”

Section: Discussionmentioning

confidence: 99%

“…In recent years the growing drug resistance in nosocomial gram-negative bacteria has resulted in treatment challenges for physicians, mostly for pediatricians [1,2]. Despite the rising relevance of Pseudomonas aeruginosa infections in adults, only a few studies have evaluated this condition in pediatric population [3,4]. This case report describes the efficacy and safety of glycylcycline antibiotic tigecycline as a salvage therapy for an infant with severe sepsis caused by multi-drug-resistant Pseudomonas aeruginosa.…”

Section: Introductionmentioning

confidence: 99%

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Tigecycline Therapy for Multi-drug-Resistant Pseudomonas aeruginosa Sepsis Associated with Multi-organ Failure in an Infant with Persistent Arterial Duct. Case Report

Krasnanova

Kováčiková

2020

SN Compr. Clin. Med.

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Sepsis is the leading cause of death in infants and children worldwide. The growing drug resistance in nosocomial gram-negative bacteria has resulted in treatment challenges. One of the most common multi-drug-resistant bacteria is Pseudomonas aeruginosa. Resistance to antibiotics used in Pseudomonas aeruginosa infections limits the therapeutic options. We present a tigecycline administration in a 5-month-old infant with patent arterial duct, heart failure, and respiratory failure due to respiratory syncytial virus bronchiolitis with subsequent respiratory distress syndrome and severe sepsis caused by multi-drug-resistant Pseudomonas aeruginosa. Despite combined antibiotic therapy with meropenem, amikacin, and colistin, inflammatory markers increased. Because of life-threatening condition, tigecycline was added to the therapy and was administered intravenously twice daily. Within 48 h, inflammatory markers started to decrease and tigecycline therapy continued for 13 days without adverse effects. Tigecycline used in combination with other antibiotics might be a valuable therapeutic approach in the management of multidrug-resistant bacteria infections in pediatric patients when conventional antibiotics have failed. Further studies are needed to evaluate the efficacy and safety of tigecycline administration in critically ill pediatric patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Tigecycline Therapy for Multi-drug-Resistant Pseudomonas aeruginosa Sepsis Associated with Multi-organ Failure in an Infant with Persistent Arterial Duct. Case Report

Krasnanova

Kováčiková

2020

SN Compr. Clin. Med.

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Primary exploring the value of metagenomic next‐generation sequencing in detecting pathogenic bacteria of cholangitis with biliary atresia after Kasai operation

Li²,

Sun³

et al. 2022

Pediatr Surg Int

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To evaluate the value of metagenomic next-generation sequencing (mNGS) in detecting pathogenic bacteria of cholangitis for patients with biliary atresia after Kasai operation. MethodsPatients of biliary atresia with cholangitis after Kasai operation who were admitted to Xi'an Children's Hospital from July 2019 to December 2021 were retrospectively analyzed. Both blood culture and mNGS were carried out in all of these patients. The detection rate of pathogenic bacteria, pathogenic bacteria spectrum, test time, in ammatory indicators and liver function were compared. The correlation between drug resistance gene and drug resistance phenotype was analyzed. All the patients were followed up for 0.5-3 years to evaluate the onset of cholangitis and the survival status of autologous liver. Resultsa total of 30 episodes of cholangitis in 25 patients were included in this study. There were signi cant differences in the detection rate of pathogenic bacteria [23.3 vs.73.3%, P < 0.05] and the test time [120 (114.5-120) vs.16 (16-21) h, P < 0.001] between the blood culture and mNGS. In ammatory indicators (CRP, PCT) and liver function (TB, DB, GGT) were compared before and after anti-infection, and there was signi cant statistical difference with two methods. Four kinds of bacteria were detected by blood cultures, and 10 kinds of bacteria were detected by mNGS. The drug-resistant phenotypes and drugresistant genotypes of 3 Klebsiella pneumoniae strains were compared, h Cholangitis occurred 3 times in 1 case (4%) and twice in 3 cases (12%). Autologous liver survived in 17 cases (68%). ConclusionCompared with traditional blood culture, mNGS is more e cient, convenient and accurate in the detection of pathogens. It provides a new method for the accurate detection of pathogenic bacteria of cholangitis with biliary atresia after Kasai operation.

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Dose optimisation based on pharmacokinetic/pharmacodynamic target of tigecycline

Yan

Wang

et al. 2021

Journal of Global Antimicrobial Resistance

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Tigecycline application in a 3-month-old infant with multiple drug resistant Klebsiella pneumonia: a case report

Cited by 6 publications

References 18 publications

Tigecycline Therapy for Multi-drug-Resistant Pseudomonas aeruginosa Sepsis Associated with Multi-organ Failure in an Infant with Persistent Arterial Duct. Case Report

Tigecycline Therapy for Multi-drug-Resistant Pseudomonas aeruginosa Sepsis Associated with Multi-organ Failure in an Infant with Persistent Arterial Duct. Case Report

Primary exploring the value of metagenomic next‐generation sequencing in detecting pathogenic bacteria of cholangitis with biliary atresia after Kasai operation

Dose optimisation based on pharmacokinetic/pharmacodynamic target of tigecycline

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