2015
DOI: 10.3748/wjg.v21.i40.11411
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Tight junction disruption:Helicobacter pyloriand dysregulation of the gastric mucosal barrier

Abstract: Long-term chronic infection with Helicobacter pylori (H. pylori) is a risk factor for gastric cancer development. In the multi-step process that leads to gastric cancer, tight junction dysfunction is thought to occur and serve as a risk factor by permitting the permeation of luminal contents across an otherwise tight mucosa. Mechanisms that regulate tight junction function and structure in the normal stomach, or dysfunction in the infected stomach, however, are largely unknown. Although conventional tight junc… Show more

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Cited by 79 publications
(57 citation statements)
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“…Since antibiotic abuse had side effects and allowed development of resistance to antibiotics, alternative strategies have been proposed to counteract H. pylori infection. As an alternative approach, preservation of mucus from H. pylori attachment is emphasized because H. pylori infection disrupted the epithelial barrier which resulted in inflammation or cancer[7]. For example, dietary inhibitors such as lacto-oligosaccharide has been suggested as a solution for H. pylori infections[8].…”
Section: Introductionmentioning
confidence: 99%
“…Since antibiotic abuse had side effects and allowed development of resistance to antibiotics, alternative strategies have been proposed to counteract H. pylori infection. As an alternative approach, preservation of mucus from H. pylori attachment is emphasized because H. pylori infection disrupted the epithelial barrier which resulted in inflammation or cancer[7]. For example, dietary inhibitors such as lacto-oligosaccharide has been suggested as a solution for H. pylori infections[8].…”
Section: Introductionmentioning
confidence: 99%
“…In a normal gut, the epithelial barrier consists of a layer of enterocytes tight junctions, anchoring junctions and desmosomes -which hinder microbes passage -goblet cells producing mucus, and Paneth cells producing antimicrobial peptides, a natural alternative to chemical antibiotics [25,26]. In the mucosal tissue, a layer of epithelial cells establish a barrier between external and internal environment and play a key role in the discrimination between pathogenic and non-pathogenic bacteria.…”
Section: Function and Preservation Of The Mechanical Intestinal Barriermentioning
confidence: 99%
“…These functions are including interference in the mitochondrial membrane, stimulation of apoptosis, and also blocking of T-cell proliferation. 9 VacA binds with LFA1/Integrin β2 receptor on T cells and is then internalized. 6 Targeted binding of VacA has been linked with the larger p55 subunit of the toxin but it has been observed that both p33 and the p55 subunits are required for internalization.…”
mentioning
confidence: 99%