2019
DOI: 10.1007/s00018-019-03030-7
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Tight junction proteins at the blood–brain barrier: far more than claudin-5

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Cited by 169 publications
(166 citation statements)
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“…While the importance of claudin-5 as a tight junction protein at the cerebral endothelium is widely recognized [59], the potential role of other claudins [60] is more contentious. Uchida et al [61] recently provided evidence in multiple sclerosis that claudin-11 is decreased at the BBB (and the blood-spinal cord and the blood-arachnoid barriers) contributing to barrier leakiness.…”
Section: Claudins At the Cerebral Endotheliummentioning
confidence: 99%
“…While the importance of claudin-5 as a tight junction protein at the cerebral endothelium is widely recognized [59], the potential role of other claudins [60] is more contentious. Uchida et al [61] recently provided evidence in multiple sclerosis that claudin-11 is decreased at the BBB (and the blood-spinal cord and the blood-arachnoid barriers) contributing to barrier leakiness.…”
Section: Claudins At the Cerebral Endotheliummentioning
confidence: 99%
“…Myelin was removed by adding dextran (60-70 kDa, 16% (w/v) final concentration; Sigma-Aldrich) and centrifugation (15 min, 4,500×g, 4 °C). The resuspended pellet was filtered (40 µm nylon mesh, Merck Millipore) and the remaining capillaries were rinsed off with DMEM and 1% (v/v) fetal calf serum (Life Technologies) (Berndt et al, 2019).…”
Section: Permeability Of the Bnb (Endoneurial Vessels)mentioning
confidence: 99%
“…For example, it was recently shown that the claudins-3 and -12 in the BBB of the mouse do not have the previously believed importance for BBB function [7,8]. In addition, there are postulated species differences that make it difficult to get a clear picture of which claudins are present in the human BBB and which function they fulfill [3]. Previous studies have in common that they prove the essential role of claudin-5 in all species.…”
Section: Introductionmentioning
confidence: 99%