Tight orbit syndrome resulting from large globe with high myopia: intractable glaucoma treated by orbital decompression

Paik, Ji Sun; Cho, Won‐Kyung; Yang, Suk‐Woo

doi:10.1111/j.1442-9071.2011.02673.x

Cited by 5 publications

(3 citation statements)

References 6 publications

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“…57,58 This is likely an extreme example of the precarious relationship of ocular and orbital pressure. 57,58 This is likely an extreme example of the precarious relationship of ocular and orbital pressure.…”

Section: Orbital Pressurementioning

confidence: 99%

Posterior Scleral Biomechanics and the Translaminar Pressure Difference

Fleischman¹,

Berdahl²

2014

International Ophthalmology Clinics

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Section: Orbital Pressurementioning

confidence: 99%

Posterior Scleral Biomechanics and the Translaminar Pressure Difference

Fleischman¹,

Berdahl²

2014

International Ophthalmology Clinics

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“…According to this study, the development of ICC and subsequent defects of inner retina are considered an important cause of VF defects in eyes with pathologic myopia. Park et al [14] prompted us to consider that an enlarged globe with tight lid may cause the eyeball to become compressed, thus elevating episcleral venous pressure, and this may also explain the mechanism underlying optic nerve damage in some patients. As Jonas et al [15] reported, simple mechanical disruption of retinal nerve fibres and increased susceptibility to developing glaucoma share a complicated relationship with pathological myopia.…”

Section: Discussionmentioning

confidence: 99%

Clinical observations of acute onset of myopic optic neuropathy in a real-world setting

Liao¹,

Fang²,

Xian³

2021

Int J Ophthalmol

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AIM: To describe the clinical features of acute myopic onset of optic neuropathy and observe the effects of retrobulbar and systemic glucocorticoid therapy in a real-world setting. METHODS: A retrospective observational case series included 18 patients with a clinical diagnosis of acute onset of myopic optic neuropathy in a real-world setting. While the patients were using retrobulbar and systemic glucocorticoid therapy, various imaging examination data were analysed, and the clinical features of myopic optic neuropathy were summarized for 6mo to 2y. RESULTS: The included group of patients with acute onset of myopic optic neuropathy consisted mostly of females (n=11). The visual field (VF) showed abnormalities in bilateral eyes, including the spread of physiological blind spots, central and paracentral dark spots, and centripetal peripheral VF reduction; but central vision with no subjective changes. The visual evoked potential (VEP) was abnormal in all eyes with vision loss. The best corrected visual acuity (BCVA) was improved from 1.04±0.63 to 0.47±0.57 (logMAR) after glucocorticoid treatment (P<0.05). In patients with a short course (within 1wk), recovery was fast and achieved the same BCVA as recorded before the onset within 6d. However, in patients with the long course (1 to 2wk), recovery was slow and did not achieve the BCVA recorded before the onset within 10d. The changes of intraocular pressure (IOP) were not obvious before and after treatment (18.68±5.30 vs 19.55±5.34 mm Hg, P>0.05). There was no recurrence during long-term follow-up observation. CONCLUSION: The acute onset of myopic optic neuropathy is characterized by BCVA and VF abnormalities in bilateral eyes. Retrobulbar and systemic glucocorticoid therapy is effective.

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“…У важких випадках виникає гостра міопічна оптична невропатія [23]. При цьому в збільшеному очному яблуці зі щільною склерою підвищується тиск епісклеральних вен (по яких відтікає внутрішньоочна рідина) і пошкоджується зоровий нерв [24].…”

Section: імовірні гіпотези щодо факторів які призводять до порушення ...unclassified

Disorders of aqueous humor flow in the posterior part of the eye in the mechanisms of optic nerve damage development (literature review)

Мойсеєнко

2023

Oftalmol Zh

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The study based on the literature search revealed that the peculiarities of fluid circulation in the posterior part of the eye have been studied insufficiently compared to the anterior part. It is suggested that the retina and optic nerve have their own cleansing system, which functions independently or in interaction with the brain's cleansing system. Of interest is the theory of the glymphatic system of the eye, which probably functions similarly to the glymphatic system of the brain, has four segments and ensures the exchange between intraocular, intracranial and interstitial fluids and the removal of metabolic waste products in the posterior part of the eye. Purpose. To determine the disorders of fluid circulation in the posterior part of the eye in the mechanisms of optic nerve damage development according to the literature. Methods: literature search of 48 sources. It is important to understand that the optic nerve under normal conditions passes a large amount of fluid from the eye to the brain and vice versa. The balance of perfusion (and, presumably, reperfusion in case of pathology) is ensured by the lamina cribrosa, the location of subarachnoid spaces in different parts of the nerve, and the AQP4 channels that support them. The question is whether the optic nerve has its own separate glymphatic system, or whether it interacts with the glymphatic system of the brain. It also remains unclear how the circulation of intraocular fluid, interstitial fluid of the retina and brain, and cerebrospinal fluid in the optic nerve is coordinated with blood, as well as with fluctuations in atmospheric pressure. Although this theory has not yet been recognized, it nevertheless has many supporters who explain optic nerve damage as a result of fluid circulation disturbances. The slowing of fluid flow, as well as the slowing of axonal transport, can be considered as the moment when neuropathy transforms into optic atrophy. That is why the study of the peculiarities of fluid flow and exchange in the posterior part of the eye is important when studying diseases of the optic nerve, whereas the correction of such circulation disorders could be used for therapeutic purposes. Conclusion. Impaired fluid circulation in the posterior part of the eye can occur in mechanisms of optic nerve damage. Improved diagnostics with the ability to assess hydrodynamics will help to understand the role of individual components, while their correction will likely contribute to the optic nerve recovery.

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Tight orbit syndrome resulting from large globe with high myopia: intractable glaucoma treated by orbital decompression

Cited by 5 publications

References 6 publications

Posterior Scleral Biomechanics and the Translaminar Pressure Difference

Posterior Scleral Biomechanics and the Translaminar Pressure Difference

Clinical observations of acute onset of myopic optic neuropathy in a real-world setting

Disorders of aqueous humor flow in the posterior part of the eye in the mechanisms of optic nerve damage development (literature review)

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