Tilapia Lake Virus (TiLV): a Globally Emerging Threat to Tilapia Aquaculture

Al-Hussinee, Lowia; Subramaniam, Kuttichantran; Surachetpong, Win; Popov, Vsevolod L.; Hartman, Kathleen H.; Starzel, Katharine; Yanong, Roy P.; Watson, Craig A.; Ferguson, H. W.; Frasca, Salvatore; Waltzek, Thomas B.

doi:10.32473/edis-fa213-2019

Cited by 6 publications

(2 citation statements)

References 16 publications

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“…Tilapia lake virus is a severe contagious pathogen that causes high mortality (20%–90%) in both farmed and wild tilapines (Al‐Hussinee et al., 2019; Bacharach et al., 2016; Dong et al., 2017; Eyngor et al., 2014; Ferguson et al., 2014; Jansen et al., 2019). The infected fish exhibited variable gross signs, that is skin erosion, scale protrusion or gill pallor to abdominal distension, anaemia, exophthalmia and abnormal behaviours.…”

Section: Introductionmentioning

confidence: 99%

Dissecting the localization of Tilapiatilapinevirus in the brain of the experimentally infected Nile tilapia, Oreochromisniloticus (L.)

Dinh-Hung

Sangpo

Kruangkum

et al. 2021

Journal of Fish Diseases

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Tilapia tilapinevirus or tilapia lake virus (TiLV) is an emerging virus that inflicts significant mortality on farmed tilapia globally. Previous studies reported detection of the virus in multiple organs of the infected fish; however, little is known about the in‐depth localization of the virus in the central nervous system. Herein, we determined the distribution of TiLV in the entire brain of experimentally infected Nile tilapia. In situ hybridization (ISH) using TiLV‐specific probes revealed that the virus was broadly distributed throughout the brain. The strongest positive signals were dominantly detected in the forebrain (responsible for learning, appetitive behaviour and attention) and the hindbrain (involved in controlling locomotion and basal physiology). The permissive cell zones for viral infection were observed mostly to be along the blood vessels and the ventricles. This indicates that the virus may productively enter into the brain through the circulatory system and widen broad regions, possibly through the cerebrospinal fluid along the ventricles, and subsequently induce the brain dysfunction. Understanding the pattern of viral localization in the brain may help elucidate the neurological disorders of the diseased fish. This study revealed the distribution of TiLV in the whole infected brain, providing new insights into fish–virus interactions and neuropathogenesis.

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Section: Introductionmentioning

confidence: 99%

Dissecting the localization of Tilapiatilapinevirus in the brain of the experimentally infected Nile tilapia, Oreochromisniloticus (L.)

Dinh-Hung

Sangpo

Kruangkum

et al. 2021

Journal of Fish Diseases

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show abstract

“…It is known that the three countries with the highest production of tilapia are China, Egypt, and Indonesia. Despite being a fish species with a relatively long lifespan, tilapia is susceptible to parasitic, viral, bacterial, and fungal infections (Al-Hussinee et al, 2019). However, studies that reported fungal infection occurrence in Indonesian tilapias are limited.…”

Section: Introductionmentioning

confidence: 99%

Isolation and Identification of Aspergillus sp. in Tilapia (Oreochromis sp.) Sold for Consumption in Bogor

Arumugam,

Budiono,

Widyananta

2024

J. Med. Vet.

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This study investigated the prevalence of Aspergillus sp. in tilapia sold for consumption at Pasarean Village in Bogor District. A total of 50 fish were sampled for further investigation. The clinical signs of fish were eroded fins, gills, haemorrhages, and wounds. The presence of pathogenic fungi was confirmed through fungal isolation from the skin, gills, and cloaca and subsequent culturing on potato dextrose agar. Macroscopic and microscopic observations determined Aspergillus sp. The results showed that four Aspergillus species were identified i.e., A. terreus (2%), A. flavus (4%), A. fumigatus (42%), and A. niger (4%), with the occurrence of co-infection between A. fumigatus and A. flavus (2%); A. fumigatus and A. terreus (2%); and between A. fumigatus, A. flavus, and A. niger (2%) reported a total prevalence of 58%. Further study is necessary to mitigate the crucial impact of fungal diseases in aquaculture systems, leading to effective prevention and control strategies, thus ensuring the safety and sustainability of aquaculture practices in Indonesia.

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Dissecting the localization ofTilapia tilapinevirusin the brain of the experimentally infected Nile tilapia (Oreochromis niloticus)

Dinh-Hung

Sangpo

Kruangkum

et al. 2021

Preprint

View full text Add to dashboard Cite

Tilapia tilapinevirus or tilapia lake virus (TiLV) is an emerging virus that inflicts significant mortality on farmed tilapia globally. Previous studies reported detection of the virus in multiple organs of the infected fish; however, little is known about the in-depth localization of the virus in the central nervous system. Herein, we determined the distribution of TiLV in the entire brain of experimentally infected Nile tilapia. In situ hybridization (ISH) using TiLV-specific probes revealed that the virus was broadly distributed throughout the brain. The strongest positive signals were dominantly detected in the forebrain (responsible for learning, appetitive behavior, and attention) and the hindbrain (involved in controlling locomotion and basal physiology). The permissive cell zones for viral infection were observed mostly to be along the blood vessels and the ventricles. This indicates that the virus may productively enter into the brain through the circulatory system and widen broad regions, possibly through the cerebrospinal fluid along the ventricles, and subsequently induce the brain dysfunction. Understanding the pattern of viral localization in the brain may help elucidate the neurological disorders of the diseased fish. This study revealed the distribution of TiLV in the whole infected brain, providing new insights into fish-virus interactions and neuropathogenesis.

show abstract

Tilapia Lake Virus (TiLV): a Globally Emerging Threat to Tilapia Aquaculture

Cited by 6 publications

References 16 publications

Dissecting the localization of Tilapiatilapinevirus in the brain of the experimentally infected Nile tilapia, Oreochromisniloticus (L.)

Dissecting the localization of Tilapiatilapinevirus in the brain of the experimentally infected Nile tilapia, Oreochromisniloticus (L.)

Isolation and Identification of Aspergillus sp. in Tilapia (Oreochromis sp.) Sold for Consumption in Bogor

Dissecting the localization ofTilapia tilapinevirusin the brain of the experimentally infected Nile tilapia (Oreochromis niloticus)

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