Tilapia viscera protein hydrolysate maintain regulatory T cells and protect acute lung injury in mice challenged with lipopolysaccharide

Riyadi, Putut Har; Romadhon, Romadhon; Anggo, Apri Dwi; Atho'illah, Mochammad Fitri; Rifa’i, Muhaimin

doi:10.1016/j.jksus.2022.102020

Cited by 6 publications

(3 citation statements)

References 32 publications

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“…The staining combinations used for detecting T-cell activation by flow cytometric were CD4 + CD62L + and CD8 + CD62L + . Populations were analyzed using flow cytometry (BD FACS CaliburTM) FlowJo v10 for Windows (Riyadi et al, 2022).…”

Section: Evaluation Of T Lymphocyte Cells (Cd4 + Cd62l + and Cd8 + Cd...mentioning

confidence: 99%

The Ameliorating Effect of Artificial Coffee from Mangrove Fruits (Rhizophora mucronata) on T Lymphocyte Cells and Renal Histopathology of BALB/c Mice Induced by Lipopolysaccharide

Cahyono,

Tanod,

Ijong

et al. 2024

Squalen Bull. Marine Fisheries Postharvest Biotech.

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The potential of Rhizophora mucronata mangrove fruits as antioxidants is noteworthy, with promising prospects as nutraceuticals, particularly in their role as immunomodulators for T lymphocyte cells. R. mucronata fruits have been utilized by household industries in Indonesia as a coffee-like drink (artificial coffee). This study aims to determine the ability of mangrove fruit artificial coffee R. mucronata to stimulate T lymphocyte cells and renal histopathology conditions in LPS-induced mice animal models. This study also characterizes proximate characteristics, antioxidant capacity, and Gas Chromatography-Mass Spectrometry (GC-MS) screening of mangrove fruit artificial coffee compounds. The stages of this research included the process of mangrove fruit artificial coffee; analysis of proximate and caffeine; compounds screening (GC-MS) and toxicity prediction (Pro-Tox II); antioxidant capacity (DPPH); T lymphocyte cell expression (flow cytometry); and renal histopathological evaluation. The results showed moisture content (5.22±0.20%); ash (5.17±0.27%); protein (13.74±0.24%); fat (11.63±0.32%); carbohydrate (64.23±0.15%), caffeine (1.09±0.04%). GC-MS analysis showed that the compounds contained in artificial coffee were derivatives of fatty aldehyde, fatty acid, and cycloalkanes compound classes. Predicted toxicity of artificial coffee LD50 5000 mg/kg. Antioxidant capacity is classified as moderate (IC50 119.41±0.99µg/mL). Mangrove fruit artificial coffee can increase the relative number of CD4+CD62L+ by 14.68-29.48% and CD8+CD62L+ T lymphocyte cells by 12.60-30.33%. Artificial coffee can also increase the number of healthy cells and reduce the cells that undergo necrosis in the renal of LPS-induced mice. This study concluded that mangrove fruit artificial coffee R. mucronata positively affects T lymphocyte activation and mice renal cells’ protection from necrosis due to LPS induction.

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Section: Evaluation Of T Lymphocyte Cells (Cd4 + Cd62l + and Cd8 + Cd...mentioning

confidence: 99%

The Ameliorating Effect of Artificial Coffee from Mangrove Fruits (Rhizophora mucronata) on T Lymphocyte Cells and Renal Histopathology of BALB/c Mice Induced by Lipopolysaccharide

Cahyono,

Tanod,

Ijong

et al. 2024

Squalen Bull. Marine Fisheries Postharvest Biotech.

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“…The Pa value was set at > 0.5. The higher Pa values indicate a higher probability of biological activity [23].…”

Section: Prediction Of Biological Activitymentioning

confidence: 99%

“…Moreover, PASS Online is also able to predict the diverse biological properties of particular organic compounds such as their mechanisms of action, pharmacological effects, interaction with enzymes and transporters, etc [22]. Due to this powerful ability, many researchers have utilized this server to conduct a preliminary prediction of the biological activity of certain compounds for molecular docking study [23][24][25]. Therefore, the aims of the study were to analyze the chemical constituents of ethanol mushroom extract from our specimen that was collected from Tasikmalaya, West Java, Indonesia utilizing Gas Chromatography-Mass Spectrometry (GC-MS) technique, then to predict the pharmaceutical potentials through PASS Server analysis.…”

Section: Introductionmentioning

confidence: 99%

First identification of potential bioactive compounds from ethanol extracts of Lepista sordida from Indonesia

Nurhayat,

Putra,

Sibero

et al. 2023

IOP Conf. Ser.: Earth Environ. Sci.

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Mushrooms species are well known to have a high potential for bioactive compounds for decades. In the era of modern technologies, it is possible to uncover and explore the hidden ethnopharmacological values, comprising complex bioactive compounds of substantial health benefits. Lepista sordida is an edible and medicinal mushroom, and its distributed from Europe to Southeast Asia. However, there was no prior study on the bioactive compounds of L. sordida from Indonesia. In this present study, ethanol extracts of L. sordida were obtained and their extract properties were determined by gas chromatography-mass spectrometry (GC-MS). A total of 13 different chemical compounds were found in L. sordida ethanol extracts through GC-MS analysis. 4-O-Methylmannose, n-Hexadecanoic acid, and cis-13-Octadecenoic acid were noted as the major compounds with area percentages of 10.09%, 8.19%, and 6.49%, respectively. The result of PASS Server analysis suggested that the ethanolic extract of L. sordida has the pharmaceutical effect to treat phobic disorder and skin damage, preventing blood clotting, anti-inflammatory, and treating several infections which cause by bacteria, protozoa, and viruses. Therefore, it is strongly suggested to conduct further bioassay to confirm the pharmaceutical properties of this mushroom.

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Oral administration of tilapia hydrolysate peptides ameliorates the immune-related side effects of cyclophosphamide in BALB/c mice

Liu,

Kuo,

Chen

et al. 2023

Food Bioscience

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Tilapia viscera protein hydrolysate maintain regulatory T cells and protect acute lung injury in mice challenged with lipopolysaccharide

Cited by 6 publications

References 32 publications

The Ameliorating Effect of Artificial Coffee from Mangrove Fruits (Rhizophora mucronata) on T Lymphocyte Cells and Renal Histopathology of BALB/c Mice Induced by Lipopolysaccharide

The Ameliorating Effect of Artificial Coffee from Mangrove Fruits (Rhizophora mucronata) on T Lymphocyte Cells and Renal Histopathology of BALB/c Mice Induced by Lipopolysaccharide

First identification of potential bioactive compounds from ethanol extracts of Lepista sordida from Indonesia

Oral administration of tilapia hydrolysate peptides ameliorates the immune-related side effects of cyclophosphamide in BALB/c mice

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