Tiling array-CGH for the assessment of genomic similarities among synchronous unilateral and bilateral invasive breast cancer tumor pairs

Brommesson, Sara; Jönsson, Göran; Strand, Carina; Grabau, Dorthe; Malmström, Per; Ringnér, Markus; Fernö, Mårten; Hedenfalk, Ingrid

doi:10.1186/1472-6890-8-6

Cited by 27 publications

(25 citation statements)

References 34 publications

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“…On the other hand, Teixera et al [21,22], using cytogenetic analysis, concluded that the dominant origin of multiple breast cancers is intramammary spread from a single primary tumor, although some cases arise by independent pathogenic processes. Recently, Brommesson et al [23] compared genomic similarities among synchronous multiple invasive breast cancers by microarray-based comparative genomic hybridization and found that 5 of 10 unilateral tumor pairs displayed similar genomic profiles, suggesting that some synchronous unilateral multiple tumors can have a common origin, whereas others arise independently.…”

Section: Discussionmentioning

confidence: 98%

The hormone receptor, human epidermal growth factor receptor 2, and molecular subtype status of individual tumor foci in multifocal/multicentric invasive ductal carcinoma of breast

Choi¹,

Kim²,

Seol³

et al. 2012

Human Pathology

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Section: Discussionmentioning

confidence: 98%

The hormone receptor, human epidermal growth factor receptor 2, and molecular subtype status of individual tumor foci in multifocal/multicentric invasive ductal carcinoma of breast

Choi¹,

Kim²,

Seol³

et al. 2012

Human Pathology

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“…Imyanitov et al determined status for all but one of 28 investigated cases, using 14 fixed markers for each tumor [5], showing a higher similarity between synchronous CBC than metachronous CBC. Two studies have used CGH to investigate the relationship between the tumors, showing that investigation of genomic imbalances can be used to detect recurrent breast tumors in both the ipsilateral and contralateral settings [6,7]. In each study, a single patient was detected to have a metastasis instead of a second primary, out of 8 bilateral cases in the Brommesson et al study, and 9 bilateral cases in the Teixeira et al study.…”

Section: Discussionmentioning

confidence: 99%

“…It is likely that for a subset of the patients, the second cancer is not a new primary tumor, but instead a metastasis of the first cancer, which could, in part, explain the poor prognosis of these patients. Several [6,7].…”

Section: Introductionmentioning

confidence: 99%

Exome sequencing of contralateral breast cancer identifies metastatic disease

Klevebring

Lindberg

Rockberg

et al. 2015

Breast Cancer Res Treat

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“…show some CBC to have features similar enough to BC1 that a metastatic spread is possible (11)(12)(13)(14)(15).…”

Section: Discussionmentioning

confidence: 99%

Prognosis, stage and oestrogen receptor status of contralateral breast cancer in relation to characteristics of the first tumour, prior endocrine treatment and radiotherapy

Alkner¹,

Ehinger²,

Bendahl³

et al. 2015

European Journal of Cancer

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Prognosis, stage and oestrogen receptor status of contralateral breast cancer in relation to characteristics of the first tumour, prior endocrine treatment and radiotherapy.Alkner, Sara; Ehinger, Anna; Bendahl, Pär-Ola; Rydén, Lisa; Fernö, Mårten Link to publication Citation for published version (APA): Alkner, S., Ehinger, A., Bendahl, P-O., Rydén, L., & Fernö, M. (2015). Prognosis, stage and oestrogen receptor status of contralateral breast cancer in relation to characteristics of the first tumour, prior endocrine treatment and radiotherapy. European Journal of Cancer, 51(16), 2304 -2313 . DOI: 10.1016 /j.ejca.2015 General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal Role of the Funding Sources:None of the funding sources had any impact on study design; the collection, analysis and interpretation of data; the writing of the report; or in the decision to submit the article for publication.3 Abstract Aim: A contralateral breast cancer (CBC) is today treated as an independent primary tumor, although recent data suggest risk and prognosis of CBC to be influenced by characteristics of and treatment given for the first tumor (BC1). We hereby investigate phenotypical and prognostic features of the second tumor (BC2) in relation to prior endocrine treatment and radiotherapy.Methods: From a well-defined population-based cohort of CBC-patients, we have constructed a unique tissue-microarray including 600 pairs of primary tumors and CBCs.Breast cancer mortality was primary end-point for prognosis. Results: Both estrogen receptor (ER) status and stage was strongly correlated between BC1and BC2 within CBC-pairs. Although BC2 had the highest prognostic impact, BC1 continued to influence prognosis after diagnosis of CBC. Patients diagnosed with two high stage tumors within a short time-interval had a particularly bad prognosis. Prior endocrine therapy and radiotherapy both correlated to ER-negativity of BC2. An ER-negative BC2 was associated with an inferior prognosis compared to an ER-positive BC2 regardless of ER-status of BC1 or prior endocrine therapy. Conclusions:Our results suggest that both the residual prognostic impact of BC1, the possibility of contralateral metastasis, as well as prior treatment given, need to be considered when determining appropriate diagnostic work-up and treatment of CBC. In addition, radiation to the contralateral breast and risk of inducing CBC with an aggressive ER-negative phenotype should be considered when establishing new radiation treatm...

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Tiling array-CGH for the assessment of genomic similarities among synchronous unilateral and bilateral invasive breast cancer tumor pairs

Cited by 27 publications

References 34 publications

The hormone receptor, human epidermal growth factor receptor 2, and molecular subtype status of individual tumor foci in multifocal/multicentric invasive ductal carcinoma of breast

The hormone receptor, human epidermal growth factor receptor 2, and molecular subtype status of individual tumor foci in multifocal/multicentric invasive ductal carcinoma of breast

Exome sequencing of contralateral breast cancer identifies metastatic disease

Prognosis, stage and oestrogen receptor status of contralateral breast cancer in relation to characteristics of the first tumour, prior endocrine treatment and radiotherapy

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