Disease resistance of rice plant is mainly genetically controlled but has a close association with the soil fertility status of the plants or pathogens; and thus, nutrient management has always been an important regulator for rice plant diseases. There is a dynamic interrelation between the soil fertility of rice plants with pathogen and abiotic environment, and hence, proper management of nutrients in cultivated rice crop can effectively reduce the severity of most diseases. Therefore, the current research is aimed to investigate the effects of mineral and organic fertizers of kernel smut incidence disease on the Giza 178 rice cultiver. Laboratory and field experiments were carried out at Rice Research & Training Center (RRTC) during 2016 and 2017 grwoing seasons. Kernel smut disease, caused by Tilletia barclayana was isolated and identificated in this study. Pathogenicity test was carried out on Giza 171, the most sensitive rice cultivar. While Giza 178 was used to field evaluated. Randomized complete block design (RCBD) experiment with three replicates was used. Farm yard manure (FYM), compost and different P, K and Zn combinations (total 15 treatments) with and without urea application were used. Chlorophyll content, leaf area, total protein, total carbohydrate, rice grain yield, disease assessment, plant analysis for total N, P, K and Zn were estimated. The results indicated that, the highest N% content was obtained from FYM+Zn and P+compost combination. There were significant differences between FYM, composts and mineral fertilizer application with and without urea on rice disease incidence. Also, chlorophyll content, leaf area and grain yield were significantally affected by applying mineral and organic fertilizer with and without urea application. The hulling% and milling% decreased by increasing the disease severity. The infection % of Giza 178 rice cultivar without urea application ranged from 6.5% to 10.20% in 2016 and 2017 seasons, respectively , while with application of urea increased the infection% to the range from 21.75% to 24.50% in the same seasons.