Tilorone hydrochloride: The drug profile

Prakash, Chandra; Wright, George J.

doi:10.1007/bfb0048451

Cited by 30 publications

(12 citation statements)

References 48 publications

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“…IRFs or the factors that regulate the IRFs (interferon consensus sequence binding protein) may well be “master switches” of the ischemic-tolerant brain, and should no doubt be investigated further. In addition to LPS and poly dI dC, in vivo treatment of animals with tilorone, a small-molecular weight interferon-inducing agent, is known to induce tolerance [7, 34]. Simultaneous with this treatment, mRNA silencing of IRF-7 or IRF-3 might reveal whether these factors are necessary for tilorone-mediated neuroprotection.…”

Section: The Changing Landscape Of Biological Discovery Informs Mechamentioning

confidence: 99%

Epigenetics and the Environment: In Search of the “Toleroasome” Vital to Execution of Ischemic Preconditioning

Brand

Ratan

2013

Transl. Stroke Res.

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Activation and repression of gene expression are key features of ischemic tolerance. Converging lines of inquiry from several groups suggests that epigenetic proteins may transduce sublethal stresses, including bio-energetic or oxidative stress into durable (2–3 days) changes in gene expression that mediate ischemic tolerance. Here we discuss the potential mechanisms by which changes in cell state (e.g., ATP, NAD+, and oxygen) can modify specific targets including polycomb complexes, jumonji domain histone demethylases, and zinc and NAD-dependent histone decetylases and thus trigger an adaptive program. A major unanswered question is whether these proteins work in parallel or convergently as part of a “tolerosome” (tolero is the Latin word for tolerance), a multiprotein complex recruited to promoters or enhancers of specific genes, to mediate preconditioning. Whatever the case may be, epigenetic proteins are fertile targets for the treatment of stroke.

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Section: The Changing Landscape Of Biological Discovery Informs Mechamentioning

confidence: 99%

Epigenetics and the Environment: In Search of the “Toleroasome” Vital to Execution of Ischemic Preconditioning

Brand

Ratan

2013

Transl. Stroke Res.

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“…A number of these modifications are also associated with viral infections as the invading viruses attempt to modify the cellular environment to promote and support vigorous virus replication. A recent report by Reeves and others [75] found the antitumor drug Gleevec capable of inhibiting vaccinia virus and raises the possibility that such drugs may be given at the same time as the vaccinia vaccination to prevent vaccine complications. …”

Section: Resultsmentioning

confidence: 99%

Antiviral Activity of Metal-Containing Polymers—Organotin and Cisplatin-Like Polymers

et al. 2011

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Polymers containing platinum and to a lesser extent tin, have repeatedly demonstrated antitumor activity in vitro and in vivo against a variety of cell and tumor types. The mechanisms responsible for the antitumor activity include inducing a delay in cell proliferation and sister chromatid exchanges blocking tumor growth. As most DNA and some RNA viruses require, and even induce, infected cells to initiate DNA replication and subsequent cell division, compounds with antitumor activity will very likely also possess antiviral activity. This article examines the use of metal-containing polymers as a novel class of antivirals.

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“…Одним з найефективніших противірусних за-собів широкого спектра дії є аміксин (1), якому притаманні: здатність індукувати інтерферон [1][2][3][4][5], імунотропна активність [6][7][8], інгібування репро-дукції вірусів в інтерфероннезалежний спосіб [9], протизапальна [10][11][12] та антиканцерогенна [13] дія, протипухлинна [14,15] та радіопротекторна активність [16][17][18], афінітет до a7нАХР [19], ан-тигіпоксична активність [20], здатність інгібува-ти перекисне окиснення ліпідів [21]. Якщо щодо деяких видів активності аміксину механізм їхньої реалізації можна вважати встановленим більш-менш точно, то стосовно механізму реалізації про-тивірусної та інтерфероніндукуючої активності досі немає загальноприйнятої точки зору.…”

Section: Issn 2308-8303 в смеси ксилола с водным раствором йодида натunclassified

Synthesis and cytotoxicity of aminoethoxydiphenyls

Zanoza¹,

Maltzev²,

Lyakhov³

et al. 2014

J. org. pharm. chem.

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В ІЧ-спектрах наявні смуги поглинання, характерні для зв'язків C-H (аром.), C-H (аліф), C-O-C та NH протонованих термінальних аміногруп. У спектрах 1 H-ЯМР наявні сигнали від ароматич-них та аліфатичних протонів, мультиплетність та інтегральна інтенсивність яких відповідає припи-суваним структурам. На клітинах ПТП вивчена цитотоксичність низки 4,4'-біс-(2-аміноетокси)дифе-нілів, значення якої зіставні з токсичністю аміксину та знаходяться в діапазоні від низьких до помірних. SYNTHESIS AND CYTOTOXICITY OF AMINOETHOXYDIPHENYLS to induce IFI in biphenyl derivatives that are incapable to intercalate in NA indicates the possibility of implementing alternative mechanisms. This determined our interest to the study of aminoethoxydiphenyls (AED), which synthesis and investigation of cytotoxicity become the subject of this article. 4,4'-Bis-(2-chloroethoxy)diphenyl was obtained by alkylation of dihydroxydiphenyl with dichloroethane in its mixture with aqueous sodium hydroxide (20%) in the presence of tetrabutylammonium chloride (TBAC). Series of AED were synthesized by substitution of chlorine by iodine in the mixture of xylene with the aqueous solution of sodium iodide in the presence of TBAC with subsequent amination with primary and secondary amines. The protonated molecular ions (MI) intensive peaks of the compounds synthesized are observed in the mass spectra with FAB ionization. The most common way of MI fragmentation is

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Tilorone hydrochloride: The drug profile

Cited by 30 publications

References 48 publications

Epigenetics and the Environment: In Search of the “Toleroasome” Vital to Execution of Ischemic Preconditioning

Epigenetics and the Environment: In Search of the “Toleroasome” Vital to Execution of Ischemic Preconditioning

Antiviral Activity of Metal-Containing Polymers—Organotin and Cisplatin-Like Polymers

Synthesis and cytotoxicity of aminoethoxydiphenyls

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