Virtual sensing enables estimation of stress in unmeasured locations of a system using a system model, physical sensors and a process model. The system model holds the relationship between the physical sensors and the desired stress response. A process model processes both the physical sensors and the system model to synthesise virtual sensors that ‘measure’ the desired stress response. Thus, virtual sensing enables mapping between the physical sensors (input) and the desired stress response (output). The system model is a mathematical model of the system based on knowledge or data of the system. Here, the data‐driven system model is constructed directly on data analyses for the specific system. In this paper, supervised learning and data‐driven system models are applied to strain estimation of an offshore wind turbine in the dynamic range through a novel use of principal component analysis (PCA); 40 min of training data is used to establish the data‐driven system model that can estimate the dynamic strain response with high precision for 2 months, while the estimated fatigue damage averaged out to −1.76% of the measured strain response.