TIM-3 genetic variants and risk of Behçet disease in the Iranian population

Abstract

Background: Behçet disease is a prototypical systemic autoimmune disease, caused by a complex interplay between environmental and genetic factors. The transmembrane immunoglobulin and mucin domain-3 (TIM-3) is a distinct member of the TIM family that is preferentially expressed on Th1 cells and plays a role in Th1-mediated autoimmune or inflammatory diseases, such as Behçet disease. oBjective: The aim of this study was to test the potential association between TIM-3 gene polymorphisms and Behçet disease. Methods: Two single-nucleotide polymorphisms of TIM-3 (rs9313439 and rs10515746) were genotyped in 212 patients with Behçet disease and 200 healthy controls. Typing of the polymorphisms was performed using multiplex PCR amplification. results: There were no significant differences in allele and genotype frequencies between the Behçet disease patients and controls who were successfully genotyped. Similar results were also found after stratification by gender, age, or clinical features. study liMitations: Lack of studies on various racial or ethnic groups and small sample size. conclusion: This study failed to demonstrate any association between the tested TIM-3 polymorphisms and Behçet disease. Approval of the final version of the manuscript. Zohreh Jadali0000-0002-3836-5262 Statistical analysis; approval of the final version of the manuscript; conception and planning of the study; elaboration and writing of the manuscript; obtaining, analyzing and interpreting the data; effective participation in research orientation; intellectual participation in propaedeutic and/or therapeutic conduct of the cases studied; critical review of the literature; critical review of the manuscript. TIM-3 genetic variants and risk of Behçet disease in the Iranian population 433An Bras Dermatol. 2019;94(4):429-33.