Time and dose-dependent impairment of liver metabolism in Gasterosteus aculeatus following exposure to diclofenac (DCF) highlighted by LC-HRMS untargeted metabolomics

Lebeau-Roche, Emmanuelle; Danièle, Gaëlle; Fildier, Aurélie; Bonnefoy, Christelle; Turiès, Cyril; Bado‐Nilles, Anne; Porcher, Jean-Marc; Dedourge-Geffard, Odile; Vulliet, Emmanuelle; Geffard, Alain

doi:10.1016/j.scitotenv.2022.159801

Cited by 6 publications

(1 citation statement)

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“…Ferrocene exposure in rainbow trout exhibited lipid peroxidation and antioxidant enzyme activities inhibition; thus, increased iron levels as a result of mining and industrial activities in freshwater ecosystems need monitoring (Özgeriş et al, 2023). Pharmaceuticals -another anthropogenic contaminant -studied by Diclofenac exposure in Gasterosteus aculeatus through metabolomics-based approaches showed that the antioxidant system is impacted in male sticklebacks (Lebeau-Roche et al, 2023). Herbicides and OA group toxins -okadaic acid and dinophysis toxin-1 have been shown to affect the juvenile/larval forms of freshwater African catfish and medaka, respectively, by altering antioxidant systems (Anih et al, 2023;Figueroa et al, 2023).…”

Section: Anthropogenic Activity Os and Fish Healthmentioning

confidence: 99%

Water physicochemical factors and oxidative stress physiology in fish, a review

Menon,

Kumar,

Middha

et al. 2023

Front. Environ. Sci.

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Fish are among the best-studied aquatic animals due to their economic and ecological values. Fish meat is the most affordable protein source for the economically weaker section of people. The environment of almost all aquatic ecosystems has a specific influential role on or by fishes. Therefore, studying their stress biology, especially oxidative stress, is vital because it can influence their growth, production, reproduction, etc. To review the above topic, peer-reviewed electronic databases, including Web of Science, science direct, PubMed, Google Scholar, Scopus, and AGRICOLA, were searched with specific keywords associated with fish, oxidative stress, diseases, etc. The influence of abiotic stress, such as the effects of water dissolved oxygen, temperature, salinity, water hardness, alkalinity, pH, pollutants, heavy metals, and anthropogenic activities, was reviewed in the current article to draw a conclusion on the updated relation that exists between fish physiology, disease, and abiotic stressors. Oxidative stress and redox regulatory levels under the above parameters were reviewed as the stress or anti-stress responses differ in various fish models. Undoubtedly, the reviewed abiotic factors modulate fish oxidative health status to a greater extent, and therefore, these factors must be considered on a priority basis to improve the general health and immunity status of fish. The statement above remains valid in both saline and freshwater habitats.

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Section: Anthropogenic Activity Os and Fish Healthmentioning

confidence: 99%

Water physicochemical factors and oxidative stress physiology in fish, a review

Menon,

Kumar,

Middha

et al. 2023

Front. Environ. Sci.

View full text Add to dashboard Cite

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A multibiomarker approach to assess the ecotoxicological effects of diclofenac on Asian clam Corbicula fluminea (O. F. Müller, 1774)

Ding

et al. 2023

Environ Sci Pollut Res

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Diclofenac (DCF), one of the most current and widely used nonsteroidal anti-in ammatory drugs (NSAIDs), has been frequently detected in aquatic environments worldwide. However, the ecotoxicological effects of DCF on freshwater invertebrates remain largely unknown. In the present study, Corbicula uminea were exposed to environmentally relevant concentrations of DCF (0, 2, 20 and 200 µg/L) for 28 days, and the potential adverse effects of DCF on siphoning behavior, antioxidant responses and apoptosis were investigated. Our results showed that the siphon e ciencies of clams were signi cantly suppressed by DCF exposure. DCF exerted neurotoxicity via reducing the activity of acetylcholinesterase (AChE) in gills and digestive gland of C. uminea. Exposure to DCF induced antioxidant stress and led to increased malondialdehyde (MDA) levels in both tissues of C. uminea. Transcriptional alterations of apoptosis-related genes indicated that DCF might induce apoptosis by triggering mitochondrial apoptotic pathway. Our ndings will help enhance our awareness of the negative effects of DCF on freshwater bivalves and highlight the ecological risks of DCF in freshwater ecosystems.

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