Time and regeneration in burns treatment: Heading into the first worldwide clinical trial with cadaveric mesenchymal stem cells

Mansilla, Eduardo; Aquino, Vanina Díaz; Roque, Gustavo; Tau, José María; Maceira, Alberto

doi:10.1016/j.burns.2011.09.007

Cited by 17 publications

(11 citation statements)

References 33 publications

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“…For the purposes of this review, we considered topical, intradermal, and subcutaneous delivery as “local” and intramuscular, parabiotic, and intravenous delivery as “systemic” ( Table 2 ). Local application with syringe-spray systems is the approach being utilized in current clinical trials [ 72 , 73 ]. It is important to know that the choice of biomimetic scaffold plays a pivotal role in driving appropriate tissue regeneration in vivo .…”

Section: Resultsmentioning

confidence: 99%

Mesenchymal Stem Cells and Cutaneous Wound Healing: Current Evidence and Future Potential

Isakson

Blacam

Whelan

et al. 2015

Stem Cells International

168

140

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Human skin is a remarkable organ that sustains insult and injury throughout life. The ability of skin to expeditiously repair wounds is paramount to survival. With an aging global population, coupled with a rise in the prevalence of conditions such as diabetes, chronic wounds represent a significant biomedical burden. Mesenchymal stem cells (MSC), a progenitor cell population of the mesoderm lineage, have been shown to be significant mediators in inflammatory environments. Preclinical studies of MSC in various animal wound healing models point towards a putative therapy. This review examines the body of evidence suggesting that MSC accelerate wound healing in both clinical and preclinical studies and also the possible mechanisms controlling its efficacy. The delivery of a cellular therapy to the masses presents many challenges from a safety, ethical, and regulatory point of view. Some of the issues surrounding the introduction of MSC as a medicinal product are also delineated in this review.

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Section: Resultsmentioning

confidence: 99%

Mesenchymal Stem Cells and Cutaneous Wound Healing: Current Evidence and Future Potential

Isakson

Blacam

Whelan

et al. 2015

Stem Cells International

168

140

View full text Add to dashboard Cite

show abstract

“…The first worldwide clinical trial involving cadaveric MSCs will be underway this year. [61] Future goals of stem cell therapy for chronic wounds should focus on rapid expansion of cells in vitro. Another option would be to maximise the number of precursor cells resident in the wound.…”

Section: Problems and Possibilitiesmentioning

confidence: 99%

Role of stem cells in the management of chronic wounds

Sharma

John

2012

Indian J Plast Surg

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Chronic wounds continue to be a major challenge for the medical profession, and plastic surgeons are frequently called in to help in the management of such wounds. Apart from the obvious morbidity to the patient, these problem wounds can be a major drain on the already scarce hospital resources. Sometimes, these chronic wounds can be more taxing than the underlying disease itself. Although many newer methods are available to handle such situations, the role of stem cells in the management of such wounds is an exciting area that needs to be explored further. A review of literature has been done regarding the role of stem cells in the management of chronic wounds. The abnormal pathology in such wounds is discussed and the possible role of stem cells for optimal healing in such cases would be detailed.

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“…In Argentina, the first clinical trial for the treatment of large burn injury, approved by the INCUCAI is now on progress. This trial consists in the local and topical application of cadaveric BMSC through a fibrinbased polymer spray covering an acellular dermal biological matrix (Mansilla et al, 2012). Importantly, this trial is being performed with allogenic MSC instead of autologous ones.…”

Section: Plastic and Reconstructive Surgerymentioning

confidence: 99%

Adipose-derived mesenchymal stem/stromal cells: from the lab bench to the basic concepts for clinical translation

Frontini-López¹,

Gojanovich²,

Masone³

et al. 2018

Biocell

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In the last years, much work has shown that the most effective repair system of the body is represented by stem cells, which are defined as undifferentiated precursors that own unlimited or prolonged self-renewal ability, which also have the potential to transform themselves into various cell types through differentiation.All tissues that form the body contain many different types of somatic cells, along with stem cells that are called 'mesenchymal stem (or stromal) cells' (MSC). In certain circumstances, some of these MSC migrate to injured tissues to replace dead cells or to undergo differentiation to repair it.The discovery of MSC has been an important step in regenerative medicine because of their high versatility. Moreover, the finding of a method to isolate MSC from adipose tissue, so called 'adipose-derived mesenchymal stem cells' (ASC), which share similar differentiation capabilities and isolation yield that is greater than other MSC, and less bioethical concerns compared to embryonic stem cells, have created self-praised publicity to procure almost any treatment with them. Here, we review the current techniques for isolation, culture and differentiation of human ASC (hASC), and describe them in detail. We also compile some advantages of the hASC over other stem cells, and provide some concepts that could help finding strategies to promote their therapeutic efficiency. BIOCELLISSN 1667-5746 (on-line) 2018 42 (3): [67][68][69][70][71][72][73][74][75][76][77]

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Time and regeneration in burns treatment: Heading into the first worldwide clinical trial with cadaveric mesenchymal stem cells

Cited by 17 publications

References 33 publications

Mesenchymal Stem Cells and Cutaneous Wound Healing: Current Evidence and Future Potential

Mesenchymal Stem Cells and Cutaneous Wound Healing: Current Evidence and Future Potential

Role of stem cells in the management of chronic wounds

Adipose-derived mesenchymal stem/stromal cells: from the lab bench to the basic concepts for clinical translation

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