The motivation of this paper is to present and test the theoretical basis for outer region 94 scaling using the freestream velocity (U ∞ ) for nonuniform open channel flows over gravel. The 95 open channel flows over gravel are classified as fully hydraulically rough turbulent flow with 96 relatively large roughness elements that can be felt throughout much of, if not the entire, flow 97 depth. We focus on a nonuniform case for these turbulent flows in which the fluid is gradually 98 varied and expanding in the vertical due to an adverse pressure gradient. In application, the 99 nonuniform flow case is general to any hydraulically rough channel flow with a backwater profile, and more specifically one such example is mountainous gravel and cobble bed rivers with decelerating pools that are constrained by streambank sidewalls.Nonuniform open channel flows over gravel is classified as a subset of turbulent boundary layer flows with a number of notable characteristics. First, the authors focus on moderate to high flow conditions typical of mountainous gravel and cobble bed rivers where fluid momentum and sediment mass transport will be high. For such conditions, the fluid will contain both appreciable inner and outer regions, the latter of which is the focus herein, and will be hydraulically rough. Moderate to high flow conditions infer moderate to high values for the relative submergence (R/D 84 >4, where R is the hydraulic radius and D 84 is the bed particle size for which 84% are finer). The relative submergence conditions will contain an inner region, termed the roughness layer for open channel flow over gravel and cobbles, that is indicative of the shedding process around particles and an outer region defined to include the overlap, wake and near-surface layers where viscous effects become small (Dittrich and Koll, 1997;Carollo et al., 2005). The hydraulically rough definition is indicated by a relatively high value for the roughness Reynolds number (k s U * ν -1 >70, k s , U * , and ν are the roughness height, friction velocity and kinematic viscosity) resulting in separation of the vertically-associated inner and outer regions with the outer region beginning one to two times the roughness height above the bed