Flow and heat transfer of non‐Newtonian power‐law fluids over an inclined square cylinder placed inside a channel are studied numerically at low Reynolds numbers. In particular, calculations are carried out for Reynolds number (Re) = 1–40; power‐law index (n) = 0.4–1 and blockage ratio (β) = 12.5–50% at a Prandtl number (Pr) = 50. An increase in blockage ratio results in an increase in the total drag coefficient and decrease in the wake length. The Strouhal number and the root mean square value of the lift coefficient increase with the increasing Reynolds number for the fixed values of blockage ratio and power‐law index. The average Nusselt number increases with power‐law index and/or blockage ratio. The maximum enhancement in heat transfer is approximately 49, 41, and 35% for the values of blockages of 50, 25, and 12.5%, respectively, as compared to the corresponding Newtonian value. The average Nusselt number for the inclined square cylinder (at α = 45°) is always greater than the average Nusselt number for the regular square cylinder (at α = 0). Finally, simple expressions of drag and Nusselt number have been established for the above range of settings. © 2013 Wiley Periodicals, Inc. Heat Trans Asian Res 43(2): 167‐196, 2014; Published online 20 June 2013 in Wiley Online Library (http://wileyonlinelibrary.com/journal/htj). DOI 10.1002/htj.21071