Time-caloric restriction inhibits the neoplastic transformation of cirrhotic liver in rats treated with diethylnitrosamine

Molina-Aguilar, Christian; Guerrero-Carrillo, María de Jesús; Espinosa-Aguirre, J.J.; Olguín-Reyes, Sitlali del Rosario; Castro-Belio, Thania; Vázquez‐Martínez, Olivia; Rivera-Zavala, Julieta Berenice; Dı́az-Muñoz, Mauricio

doi:10.1093/carcin/bgx052

Cited by 13 publications

(8 citation statements)

References 34 publications

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“…Simple steatosis begins in the centrilobular liver zone. The result of Molina-Aguilar et al (18) indicate that time-caloric restriction reduced hepatomegaly and prevented the increase in blood leukocytes promoted by diethylnitrosamine. Also effects of short food restriction on hepatocytes are visible, but the changes after ADL nutrition are more visible in our study.…”

Section: Discussionmentioning

confidence: 96%

The relationship between hepatocytes and small bowel after early and short food restriction: What the results show in morphometry

Makovický¹,

Tůmová²,

Volek³

et al. 2018

BLL

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The objective of this study was to evaluate the relationship between hepatocyte morphometry and small bowel architecture after early and short food restriction. Altogether 48 Hyplus broiler rabbits were divided into three groups. The control group was fed ad libitum (ADL) throughout the experiment (C). The fi rst group were foodrestricted between 32 and 39 days of age, when the rabbits received 50g of food per rabbit each day (R1). The second group was restricted between 32 and 39 days and the rabbits received 65g of food per rabbit each day (R2). In 39 and in 81 days eight rabbits from all three groups were euthanized. The diameter of centrilobular, midzonal and periportal hepatocytes and the height of villi, the width of villi and the crypt depth were measured. The hepatocytes grew from centrilobular to perilobular part in the C group, but in the R1 and R2 group, an opposite trend was noticed. On day 39 and daye 81 the elevations of villi were the highest. Interestingly, the nadirs of the crypts were deepest in the C group compared to the R1 and R2 groups. Early short intensive food restriction may play a role in the prevention of liver diseases (Tab. 2, Ref. 20). Text in PDF www.elis.sk.

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Section: Discussionmentioning

confidence: 96%

The relationship between hepatocytes and small bowel after early and short food restriction: What the results show in morphometry

Makovický¹,

Tůmová²,

Volek³

et al. 2018

BLL

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“…To our knowledge, this is the first investigation to describe a direct beneficial effect of long term TRF on early phases of carcinogenesis. It was recently reported that a time-caloric restricted diet could inhibit progression from cirrhosis to hepatocellular carcinoma induced by chronic administration of diethylnitrosamine [45]. However, feeding time in this study was reduced to 2 hours, resulting in a sizeable (~30%) decrease in daily caloric intake.…”

Section: Discussionmentioning

confidence: 76%

Time-restricted feeding delays the emergence of the age-associated, neoplastic-prone tissue landscape

Serra

Marongiu

Pisu

et al. 2019

Aging

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Aging increases the risk of cancer partly through alterations in the tissue microenvironment. Time-restricted feeding (TRF) is being proposed as an effective strategy to delay biological aging. In the present studies, we assessed the effect of long-term exposure to TRF on the emergence of the age-associated, neoplastic-prone tissue landscape. Animals were exposed to either ad libitum feeding (ALF) or TRF for 18 months and then transplanted with hepatocytes isolated from pre-neoplastic nodules. Both groups were continued ALF and the growth of transplanted cells was evaluated 3 months later. A significant decrease in frequency of larger size clusters of pre-neoplastic hepatocytes was seen in TRF-exposed group compared to controls. Furthermore, TRF modified several parameters related to both liver and systemic aging towards the persistence of a younger phenotype, including a decrease in liver cell senescence, diminished fat accumulation and up-regulation of SIRT1 in the liver, down-regulation of plasma IGF-1, decreased levels of plasma lipoproteins and up-regulation of hippocampal brain-derived growth factor (BDNF).These results indicate that TRF was able to delay the onset of the neoplastic-prone tissue landscape typical of aging. To our knowledge, this is the first investigation to describe a direct beneficial effect of TRF on early phases of carcinogenesis.

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“…The percentage and/or number of MDSCs was also reduced in two studies (45,136). The number of total circulating leukocytes and lymphocytes was reduced in two studies (133,140), while increased lymphocyte proliferation was found in another study (141). Among the serum cytokines evaluated, TNFα was reduced in one study (128) and increased in another study (140).…”

Section: Preclinical Findingsmentioning

confidence: 93%

Impact of physical activity and energy restriction on immune regulation of cancer

Xu¹,

Rogers²

2020

Transl Cancer Res TCR

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Cancer is a major public health issue worldwide. Lifestyle factors, such as body weight and physical activity (PA), significantly impact cancer risk and progression. There is strong evidence that PA reduces and obesity increases risk and mortality from numerous cancer types. Energy restriction (ER) in non-obese hosts significantly reduces tumor incidence in a variety of preclinical models, and reduces body weight and cardiometabolic risk factors in humans. Emerging data suggest that PA-and ER-induced changes in inflammatory and immune mediators may contribute to the cancer prevention effects of these interventions. A systematic literature search was conducted to identify studies that evaluated the impact of PA and ER on tumor and immune outcomes in humans and animal models. A total of 97 eligible studies were identified (68 studies reporting PA interventions and 30 studies reporting ER interventions). Thirtyone studies investigated the effect of PA on cancer immune outcomes using preclinical cancer models of breast (n=17, 55%), gastrointestinal (n=6, 19%), melanoma (n=4, 13%), and several other cancer types (n=4, 13%). Despite the heterogeneity in study designs, the majority of studies (n=23, 74%) reported positive effects of PA on tumor outcomes. Thirty-seven clinical studies investigated the effect of PA on cancer immune outcomes. None reported tumor outcomes, thus only immune outcomes were evaluated in these studies. PA studies were conducted in patients with breast (n=22, 59%), gastrointestinal (n=5, 14%), prostate (n=2, 5%), esophageal (n=1, 3%), lung (n=1, 3%) cancer, leukemia (n=1, 3%), or mixed cancer types (n=5, 14%). Twenty-two studies investigated the effect of ER interventions on cancer immune outcomes using preclinical cancer models including breast (n=5, 23%), gastrointestinal (n=5, 23%), lung (n=2, 9%), liver (n=2, 9%), pancreatic (n=2, 9%), and several other cancer types (n=6, 27%). Positive effects of ER on tumor outcomes were reported in 21 of 22 studies. Six clinical studies investigated the effect of ER (in combination with PA) on tumor immune outcomes in cancer patients with overweight or obesity. Five were conducted in breast cancer patients, and one recruited patients of a mix of cancer types. A wide range of immunological parameters including immune cell phenotype and function, cytokines, and other immune and inflammatory markers were assessed in multiple tissue compartments (blood, spleen, lymph nodes and tumor) in the included studies. Results from preclinical and clinical studies suggest that both PA and ER exert heterogeneous effects on circulating factors and systemic immune responses. PA + ER alters the gene expression profile and immune infiltrates in the tumor which may result in a reduction in immune suppressive factors. However, additional studies are needed to better understand the effect of PA and/or ER on immunomodulation, particularly in the tumor microenvironment (TME).

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Time-caloric restriction inhibits the neoplastic transformation of cirrhotic liver in rats treated with diethylnitrosamine

Cited by 13 publications

References 34 publications

The relationship between hepatocytes and small bowel after early and short food restriction: What the results show in morphometry

The relationship between hepatocytes and small bowel after early and short food restriction: What the results show in morphometry

Time-restricted feeding delays the emergence of the age-associated, neoplastic-prone tissue landscape

Impact of physical activity and energy restriction on immune regulation of cancer

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