Time course and attenuation of ischaemia-reperfusion induced oxidative injury by propofol in human renal transplantation

Basu, Samar; Meisert, Isabelle; Eggensperger, Elisabeth; Krieger, Elisabeth; Krenn, Claus G.

doi:10.1179/135100007x200281

Cited by 24 publications

(12 citation statements)

References 38 publications

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“…Propofol protected cells from apoptosis by inhibiting oxidative stress and the corresponding downstream pathways, such as mitochondrial stress [54]. Propofol may counteract oxidative stress by lowering the formation of F(2)-isoprostane, a marker of oxidative stress, during transplantation and post-surgery [55]. Propofol also modulates systemic inflammation resulting from IR by decreasing the expression of nuclear factor-κB, a nuclear transcription factor that plays a key role in oxidative stress (Fig.…”

Section: General Anesthesiamentioning

confidence: 99%

A Review of Anesthetic Effects on Renal Function: Potential Organ Protection

et al. 2017

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Background: Renal protection is a critical concept for anesthesiologists, nephrologists, and urologists, since anesthesia and renal function are highly interconnected and can potentially interfere with one another. Therefore, a comprehensive understanding of anesthetic drugs and their effects on renal function remains fundamental to the success of renal surgeries, especially transplant procedures. Some experimental studies have shown that some anesthetics provide protection against renal ischemia/reperfusion (IR) injury, but there is limited clinical evidence. Summary: The effects of anesthetic drugs on renal failure are particularly important in the context of kidney transplantation, since the conditions of preservation following removal profoundly influence the recovery of organ function. Currently, preservation procedures are typically based on the usage of a cold-storage solution. Some anesthetic drugs induce anti-inflammatory, anti-necrotic, and anti-apoptotic effects. A more thorough understanding of anesthetic effects on renal function can present a novel approach for developing organ-protective strategies. The aim of this review is to discuss the effects of different anesthetic drugs on renal function, with particular focus on IR injury. Many studies have demonstrated the organ-protective effects of some anesthetic drugs, specifically propofol, which indicate the potential of some anesthetics to introduce novel organ protective targets. This is not surprising, since lipid emulsions are major components of propofol, which accumulating data show provide organ protective effects against IR injury. Key Messages: Thorough understanding of the interaction between anesthetic drugs and renal function remains fundamental to the delivery of safe perioperative care and to optimizing outcomes after renal surgeries, particularly transplant procedures. Anesthetics can be repurposed for organ protection with more information about their effects, especially during transplant procedures. Here, we review the effects of different anesthetic drugs – specifically those that contain lipids in their structure, with special reference to IR injury.

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Section: General Anesthesiamentioning

confidence: 99%

A Review of Anesthetic Effects on Renal Function: Potential Organ Protection

et al. 2017

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“…They also reported in the same study; thiopental decreases the kidney I/R damage via free oxygen radicals in rats, and this effect is significant compared to etomidate [13] . Basu et al [23] studied oxidative stres after renal transplantation and inflamatory response and they compared propofol and thiopental. As a result they reported that propofol depressed the inflamatory response [23] .…”

Section: Discussionmentioning

confidence: 99%

“…Basu et al [23] studied oxidative stres after renal transplantation and inflamatory response and they compared propofol and thiopental. As a result they reported that propofol depressed the inflamatory response [23] . The Protective Effect of ...…”

Section: Discussionmentioning

confidence: 99%

“…Thiopental is a highly lipid-soluble anesthetic, which has indicated antioxidant effect by inhibiting lipid peroxidation in ischemia/reperfusion injury [17] . Protective effects of thiopental for renal ischemia/reperfusion injury was searched in several and compared with the other intravenous agents [13,17,23] . Yüzer et al [13] reported that propofol and thiopental anesthesia protects against biochemical, and morphological damage better than control in renal I/R injury.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Ratlarda Böbrek İşemi/Reperfüzyon Hasarına Karşı Tiyopentalin Koruyucu Etkisi

Çoşkuner¹,

Türkay²,

Yıldız³

et al. 2016

Kafkas Univ Vet Fak Derg

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The aim of this study was to determine optimal protective thiopental dose in renal ischemia/reperfusion (I/R) damage. This study was carried out on 42 rats. After abdominal midline incision, left renal artery was occluded. After 60 min of ischemia and reperfusion, a left nephrectomy was performed. Surgical intervention was made for the six rat groups (excluding sham group). In control group, 60 minutes of ischemia and reperfusion were applied to left kidneys. Thiopental (3, 10, 30, 60, 80 mg/ kg) was applied intra-peritoneally to the rats except sham and control groups 15 minutes before reperfusion. After reperfusion, IL-1α, IL-6, TNF-α levels; SOD activity; MDA and NO levels were measured. There was no decrease in IL-6 or TNF-α levels in groups at all doses. IL-1α levels only decreased in the group receiving 3 mg/kg thiopental. Only the group receiving 80 mg/kg observed decrease in MDA levels. The rats receiving 30 mg/kg showed significant increase in SOD levels. The rats receiving 3 mg/ kg detected significant increase in glutathione peroxidase (GPx) levels. The groups receiving 10, 30, and 60 mg/kg thiopental showed decrease in nitric oxide (NO) levels. According to study results, different doses of thiopental affected each biochemical indicator in renal I/R damage. Keywords: Renal Ischemia/Reperfusion, Thiopental, Rat Ratlarda Böbrek İşemi/Reperfüzyon Hasarına Karşı Tiyopentalin Koruyucu Etkisi ÖzetÇalışmada ratlarda farklı dozlarda uygulanan tiyopentalin renal I/R hasarına karşı koruyucu optimal dozunun saptanması amaçlandı. Bu çalışma 42 ratta yapıldı. Abdominal orta hat insizyonu sonrası sol renal arter okluzyonu yapıldı. Altmış dakika işemi ve reperfüzyondan sonra sol nefrektomi yapıldı. Altışar rattan oluşan gruplarda (sham grup dışında) cerrahi prosedür uygulandı. Kontrol grubunda sol böbreklere 60 dk işemi ve reperfüzyon uygulandı. Sham ve kontrol grubu dışındaki ratlara reperfüzyondan 15 dk önce tiyopental (3, 10, 30, 60, 80 mg/kg) intra-peritoneal olarak uygulandı. Reperfüzyon sonunda IL-1α, IL-6, TNF-α seviyeleri; SOD aktivitesi; MDA ve NO düzeyleri ölçüldü. Gruplarda IL-6 ve TNF-α seviyelerinde azalma olmadı. Yalnızca 3 mg/kg tiyopental uygulanan grupta IL-1α seviyesi azaldı. MDA düzeylerinde düşme yalnızca 80 mg/kg tiyopental uygulanan grupta görüldü. 30 mg/ kg tiyopental uygulanan ratlarda SOD düzeylerinde anlamlı yükseklik saptandı. 3 mg/kg tiyopental uygulanan ratlarda glutatyon peroksidaz (GPx) düzeylerinde anlamlı yükseklik saptandı. Nitrik oksit seviyesindeki düşme 10, 30 ve 60 mg/kg tiyopental uygulanan gruplarda görüldü. Çalışma sonuçlarına göre, renal işemi reperfüzyon hasarında her bir biyokimyasal belirteci tiyopentalin farklı dozları etkiledi.

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“…The results of several clinical trials are eagerly awaited. Propofol is another anaesthetic agent that may reduce I/R injury [161,162]. Experimental models have highlighted the anti-oxidant and anti-apoptotic properties of the agent [161,162].…”

Section: Experimental Agentsmentioning

confidence: 99%