Time course and substance P effects on the vascular and morphological changes in adjuvant-induced monoarthritic rats

Lam, Francis Fy; Wong, Hilda H.L; Ng, Ethel S.K

doi:10.1016/j.intimp.2004.01.009

Cited by 22 publications

(22 citation statements)

References 39 publications

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“…1c). These observations have confirmed what others have reported in animal models of monoarthritis and are also consistent with the human disease condition [32,36]. However, in addition it was observed that the scar tissue extended into the synovial cavity in the form of pannus tissue, the base of which encroached upon the underlying cartilage and bone (Fig.…”

Section: Histologysupporting

confidence: 91%

“…Meloxicam is a potent antiinflammatory agent that is commonly prescribed to treat arthritic conditions [29,30]. Moreover, inhibition of COX-2 has beneficial effects on nociceptive scores in animal models of inflammatory joint disease [31][32][33]. However, most studies have examined only the effects of acute inhibition of COX-2 [32,33] and longer treatment regimens measured effects only during the early phase of model development and on a restricted number of functional readouts.…”

Section: Introductionmentioning

confidence: 99%

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Sensory and vascular changes in a rat monoarthritis model: prophylactic and therapeutic effects of meloxicam

et al. 2010

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Section: Histologysupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Sensory and vascular changes in a rat monoarthritis model: prophylactic and therapeutic effects of meloxicam

et al. 2010

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“…Substance P stimulates acute plasma protein extravasation when injected into joints (39,40), although its possible role in more severe and chronic phases of disease is unclear (40,41). However, we have recently shown that there was no difference in responses in the CFA-induced model of joint inflammation, used in the present study, in WT versus neurokinin 1-knockout mice after 18 hours (20).…”

Section: Discussionmentioning

confidence: 53%

Involvement of transient receptor potential vanilloid 1 in the vascular and hyperalgesic components of joint inflammation

Keeble¹,

Russell²,

Curtis³

et al. 2005

Arthritis & Rheumatism

155

117

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Objective. To investigate the endogenous involvement of transient receptor potential vanilloid 1 (TRPV1) in a model of knee joint inflammation in the mouse.Methods. Following characterization of wild-type (WT) and TRPV1-knockout mice, inflammation was induced via intraarticular (IA) injection of Freund's complete adjuvant (CFA). Knee swelling was assessed as diameter, and inflammatory heat hyperalgesia was determined using the Hargreaves technique, for up to 3 weeks. At 18 hours, acute hyperpermeability was measured with 125 I-albumin, and cytokines and myeloperoxidase activity, a marker of neutrophils, were assayed in synovial fluid extracts. The possibility that exogenous tumor necrosis factor ␣ (TNF␣) was involved in influencing TRPV1 activation was investigated in separate experiments.Results. Increased levels of knee swelling, hyperpermeability, leukocyte accumulation, and TNF␣ were found in WT mice 18 hours after IA CFA treatment compared with saline treatment. Significantly less knee swelling and hyperpermeability were found in TRPV1 ؊/؊ mice, but leukocyte accumulation and TNF␣ levels were similar in WT and TRPV1 ؊/؊ mice. Knee swelling in response to CFA remained significantly higher for a longer period in WT mice compared with TRPV1 ؊/؊ mice, with thermal hyperalgesic sensitivity observed at 24 hours and at 1 week in WT, but not TRPV1 ؊/؊ , mice. Knee swelling was attenuated (P < 0.05) in TRPV1 ؊/؊ compared with WT mice 4 hours after IA administration of TNF␣.Conclusion. Our findings indicate that TRPV1 has a role in acute and chronic inflammation in the mouse knee joint. Thus, selective antagonism of TRPV1 should be considered as a potential target for treatment of acute and chronic joint inflammation.

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“…Each joint and paw were measured three times and the average of the three data was taken as the final value (Lam et al, 2004).…”

Section: Measurement Of Progression Of Paw and Joint Edemamentioning

confidence: 99%

Extracts of Arisaema rhizomatum C.E.C. Fischer attenuate inflammatory response on collagen-induced arthritis in BALB/c mice

Chen¹,

Zhang²,

Huifang³

et al. 2011

Journal of Ethnopharmacology

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Time course and substance P effects on the vascular and morphological changes in adjuvant-induced monoarthritic rats

Cited by 22 publications

References 39 publications

Sensory and vascular changes in a rat monoarthritis model: prophylactic and therapeutic effects of meloxicam

Sensory and vascular changes in a rat monoarthritis model: prophylactic and therapeutic effects of meloxicam

Involvement of transient receptor potential vanilloid 1 in the vascular and hyperalgesic components of joint inflammation

Extracts of Arisaema rhizomatum C.E.C. Fischer attenuate inflammatory response on collagen-induced arthritis in BALB/c mice

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