Time-course changes in the expression of heme oxygenase-1 in human subcutaneous hemorrhage

Nakajima, Toru; Hayakawa, Motozo; Yajima, Daisuke; Motani-Saitoh, Hisako; Sato, Yoshiaki; Kiuchi, Masahiro; Ichinose, Masaharu; Iwase, Hirotaro

doi:10.1016/j.forsciint.2005.05.028

Cited by 14 publications

(9 citation statements)

References 42 publications

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“…Expression of HO-1 can be induced mainly in the glia by various stress-inducing pathological conditions (Maines and Gibbs, 2005;Nakajima et al, 2006;Wang et al, 2011). In the past decade, most studies have focused on the protective effects of HO-1 in the nervous system.…”

Section: Heme Oxygenase and Neuroprotectionmentioning

confidence: 99%

Heme oxygenase in neuroprotection: from mechanisms to therapeutic implications

Chen¹

2014

Reviews in the Neurosciences

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Section: Heme Oxygenase and Neuroprotectionmentioning

confidence: 99%

Heme oxygenase in neuroprotection: from mechanisms to therapeutic implications

Chen¹

2014

Reviews in the Neurosciences

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“…A blood sampling at 48 hours is a reasonable choice on the basis of the time course of HO-1 upregulation. 10,15 Blood tests…”

Section: Participantsmentioning

confidence: 99%

Does Guasha Offer Hepatoprotective Effect to Chronic Inactive Hepatitis B Carriers? A Built-in Design to Control Subject Expectation

Chan

Yuen

Gohel

et al. 2013

The Journal of Alternative and Complementary Medicine

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In contrast to results in active-CHB patients, Guasha did not induce any significant modulation of liver enzymes, HO-1, or cytokines in inactive-CHB and NC participants. The current results suggest that a Guasha-induced hepatoprotective effect depends on the inflammatory event or clinical stage of chronic hepatitis B. Because both active and inactive carriers were completely unaware of their liver status at the time of receiving Guasha, the research protocol is effective in discounting the model that attributes the Guasha therapeutic efficacy to a placebo effect due to participants' expectations.

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“…The diagnosis is usually not difficult, referring to classic morphological findings of vital reaction involving bleeding with clots and/or tissue injury with inflammatory cell infiltrations. With respect to these, the usefulness of immunohistochemical and biochemical detections of chemical mediators and inflammatory cell markers that contribute to serial inflammatory reactions has been reported [45][46][47][48][49][50][51][52]. However, a precise interpretation may be difficult in a death immediately after an insult leaving no definite morphological signs of vital reactions.…”

Section: Conceptmentioning

confidence: 99%

“…In forensic pathology, however, precise analyses of serial changes are required based on the findings at the time of death. For this purpose, previous studies have provided an abundance of immunohistochemical and biochemical data with relevance to classical pathomorphology, including serial expressions of apoptosis and inflammatory response markers [45][46][47][48][49][50][51][52]. Considering the biological characteristics of mRNA expressions, analyses of molecular biological changes prior to the appearance of gene products, combined with immunohistochemistry of the products, are effective; animal studies suggested time-dependent expressions of cytokine and chemokine mRNAs after skin injury [53][54][55][56][57][58][59][60][61][62][63][64].…”

Section: Woundmentioning

confidence: 99%