Time course changes of cystatin C and inflammatory and biochemical markers in non-ST-elevation acute coronary syndromes

Servi, Stefano De; Mariani, Giuseppe; Piatti, Luigi; Leoncini, Mario; Rubartelli, Paolo; Pitì, Antonio; Curello, Salvatore; Galdangelo, F; Vandoni, Pietro; Rossetti, E.; Mariani, Matteo; Boschetti, Enrico; Re, Gianpietro; Loznicker, Milvia

doi:10.2459/jcm.0b013e328365a275

Cited by 10 publications

(11 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, this is likely to be more relevant following an acute infarction as has been demonstrated in experimental models (Deten, Volz, Briest, & Zimmer, 2002;. In clinical settings, cytokines including IL6 are acutely elevated during ST-or non-ST-elevation acute coronary syndromes (De Servi, et al, 2014;Neumann, et al, 1995). Markers of inflammation are also elevated in heart failure which can be reduced by cardiac resynchronization therapy (Rubaj, et al, 2013).…”

Section: Inflammatory State Prior To Surgerymentioning

confidence: 96%

Inflammation, oxidative stress and postoperative atrial fibrillation in cardiac surgery

Zakkar

Ascione

James

et al. 2015

Pharmacology & Therapeutics

191

129

View full text Add to dashboard Cite

Postoperative atrial fibrillation (POAF) is a common complication of cardiac surgery that occurs in up to 60% of patients. POAF is associated with increased risk of cardiovascular mortality, stroke and other arrhythmias that can impact on early and long term clinical outcomes and health economics. Many factors such as disease-induced cardiac remodelling, operative trauma, changes in atrial pressure and chemical stimulation and reflex sympathetic/parasympathetic activation have been implicated in the development of POAF. There is mounting evidence to support a major role for inflammation and oxidative stress in the pathogenesis of POAF. Both are consequences of using cardiopulmonary bypass and reperfusion following ischaemic cardioplegic arrest. Subsequently, several anti-inflammatory and antioxidant drugs have been tested in an attempt to reduce the incidence of POAF. However, prevention remains suboptimal and thus far none of the tested drugs has provided sufficient efficacy to be widely introduced in clinical practice. A better understanding of the cellular and molecular mechanisms responsible for the onset and persistence of POAF is needed to develop more effective prediction and interventions.

show abstract

Section: Inflammatory State Prior To Surgerymentioning

confidence: 96%

Inflammation, oxidative stress and postoperative atrial fibrillation in cardiac surgery

Zakkar

Ascione

James

et al. 2015

Pharmacology & Therapeutics

191

129

View full text Add to dashboard Cite

show abstract

“…The kidneys play a major role in the metabolism of cystatin C and this compound is considered a reliable marker of kidney disease. Its role as a marker for cardiovascular disease (CVD) is under investigation, in the acute setting (Negrusz‐Kawecka et al., ) and stable (De Servi et al., ) phase of a MI. GDF‐15 is a recently discovered protein, mainly expressed by macrophages activated by inflammatory stimuli (Hohensinner, Niessner, Huber, Weyand, & Wojta, ).…”

Section: Introductionmentioning

confidence: 99%

“…Plasma levels of NT‐proBNP are elevated in patients with heart failure and have been used both for diagnostic purposes and to guide therapy (Savarese et al., ). In addition, NT‐proBNP levels are increased in the presence of an acute MI (Cochet et al., ) and although the hormone levels decrease with time, they remain elevated in the post‐MI period (De Servi et al., ) indicating sustained myocardial damage.…”

Section: Introductionmentioning

confidence: 99%

Saliva and plasma levels of cardiac‐related biomarkers in post‐myocardial infarction patients

Rathnayake

Buhlin

Kjellström

et al. 2017

J Clinic Periodontology

View full text Add to dashboard Cite

show abstract

“…increase during acute phase and then return to baseline levels during the stable chronic phase. In a recent paper our group evaluated this still unexplored issue of the time course of serum Cys-C concentrations over the first 6 weeks after an acute ischemic cardiac episode in a highly selected homogeneous cohort of NSTE-ACS patients, correlating such measurements with those of other inflammatory and biomechanical stress markers obtained in two blood samples of these patients [36] . In this prospective, multicenter study, 222 patients with a first NSTE-ACS associated with a single-vessel coronary disease and treated with successful percutaneous revascularization at 16 Italian hospitals were enrolled.…”

Section: Cystatin-c Changes In Acute Coronary Syndromesmentioning

confidence: 99%

Clinical Significance of Cystatin C in Acute Coronary Syndromes: Something More Than a Marker of Renal Function?

Mariani¹,

Mariani²,

Servi³

2014

Inflamm Cell Signal

View full text Add to dashboard Cite

Serum cystatin C (Cys-C) levels perform better than other markers of renal function as indicator of cardiovascular outcome both in population-based studies and in patients with non-ST-elevation acute coronary syndrome (NSTE-ACS). Whether the relation between elevated serum Cys-C levels and risk of a worse cardiovascular prognosis reflects a more precise measurement of renal function or an association with nonrenal factors such as inflammation is a matter still poorly defined. In a prospective, multicenter study our group evaluated the time course of serum Cys-C levels in 222 patients over the first 6 weeks after an episode of NSTE-ACS and a successful percutaneous revascularization. We observed that Cys-C levels slightly but significantly increased from the admission to 6-week samples (7.1 to 7.8 mg/dL, p <0.0001), contrary to high sensitivity C Reactive Protein (hsCRP), N-terminal portion of the proBNP peptide (NT-proBNP), and Interleukin 6 (IL-6) levels which significantly decreased in the same period. Cys-C levels were not different in patients with or without elevated troponin (c-TnT), whereas the other inflammatory and biomechanical markers showed higher values in patients with versus those without increased c-TnT. Cys-C was highly correlated with estimated glomerular filtration rate both in ACS and 6-week samples. In conclusion, our data seem to contradict the hypothesis that inflammation is a determinant of the Cys-C levels because they did not show the typical pattern of an acute-phase reactant and secondly they were independent from myocardial necrosis diagnosed by c-TnT levels. Moreover, our results show that Cys-C remains a reliable marker of renal function also during ACS because is not influenced by myocardial necrosis or by acute left ventricular disfunction, as detected by increased NT-proBNP values.

show abstract

Time course changes of cystatin C and inflammatory and biochemical markers in non-ST-elevation acute coronary syndromes

Abstract: In contrast to inflammatory and biochemical stress markers, Cys-C is not affected by the occurrence of myocardial necrosis or by acute left-ventricular impairment, being a reliable marker of renal function during NSTE-ACS.

Cited by 10 publications

References 28 publications

Inflammation, oxidative stress and postoperative atrial fibrillation in cardiac surgery

Inflammation, oxidative stress and postoperative atrial fibrillation in cardiac surgery

Saliva and plasma levels of cardiac‐related biomarkers in post‐myocardial infarction patients

Clinical Significance of Cystatin C in Acute Coronary Syndromes: Something More Than a Marker of Renal Function?

Contact Info

Product

Resources

About