Time-course changes of nLDL-induced erectile dysfunction

Durmus, Nergiz; Toylu, Asli; Evcim, S; Soner, Burak Cem; Demir, Ömer; Kahraman, Erkan; Demir, Tevfik; İrer, Bora; Gidener, Sedef; Atabey, Neşe; Esen, Ahmet Adil

doi:10.1038/ijir.2017.5

Cited by 5 publications

(5 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The same finding was observed in cross-sectional studies included in a literature review conducted in 2009 [ 24 ]. Likewise, similar reports demonstrated that hyperlipidaemia was a significant risk factor for developing ED among this group of patients across the globe [ 34 – 37 ]. In contrast to this finding, one study documented a non-significant relationship between ED and dyslipidaemia among males with DM in Sri Lanka [ 7 ].…”

Section: Discussionmentioning

confidence: 61%

“…The significant association may reflect the negative effects of hyperlipidaemia on the vascular smooth muscle tissue of the penis and the peripheral cavernous nerve [ 38 , 39 ]. Moreover, hyperlipidaemia-induced impairments in erectile functions might be related to an increase in plasma asymmetrical dimethylarginine levels, changes in the regulation of the endothelial nitric oxide synthase (eNOS) levels, and eNOS expression in cavernous tissues [ 37 ]. Additionally, one study revealed that different statin types might have different effects on erectile dysfunction [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Prevalence and associated factors of erectile dysfunction in men with type 2 diabetes mellitus in eastern Sudan

et al. 2022

View full text Add to dashboard Cite

Background Diabetes mellitus (DM) is a global health threat and burden that is associated with many chronic complications. Erectile dysfunction (ED) among patients with DM is one of these complications. There is no published data on ED in Sudan; hence, we conducted this study to evaluate the prevalence of ED and the associated factors in patients with type 2 diabetes mellitus (T2DM) in eastern Sudan. Methods We performed a cross-sectional study. Data on blood glucose level, cholesterol level, anthropometric and demographic characteristics, results of the International Index of Erectile Function (IIEF-5) questionnaire, and clinical history were obtained. Results A total of 334 men with T2DM with a median (interquartile range [IQR]) age of 55.0 (±10.0) years were enrolled in the study. The median (IQR) of the duration of DM was 7.0 (±8) years, and 260 (77.8%) had uncontrolled T2DM. The median (IQR) body mass index was 24.5 (±4.9) kg/m2. Of the participants, 81 (24.3%) had severe ED, 52 (15.6%) had moderate ED, 75 (22.5%) had mild to moderate ED, and 63 (13.9%) had mild ED. Of the 334 men, 271 (81.1%) had ED. Logistic regression analysis showed that age (adjusted Odds Ratio [AOR] = 1.07, 95% confidence interval [CI] = 1.01–1.14), duration of DM (AOR = 1.26, 95% CI = 1.06–1.51), and cholesterol levels (AOR = 3.53, 95% CI = 1.75–7.11) were positively associated with ED. Moreover, poor glycaemic control (AOR = 3.38, 95% CI = 1.70–6.71, P < 0.001) was significantly associated with ED. Conclusion There is a high prevalence of ED among patients with T2DM in eastern Sudan. Age, duration of DM, and cholesterol were positively associated with ED.

show abstract

Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Prevalence and associated factors of erectile dysfunction in men with type 2 diabetes mellitus in eastern Sudan

et al. 2022

View full text Add to dashboard Cite

show abstract

“…We showed that LDL‐C and HDL‐C are associated with arteriogenic erectile dysfunction which confirmed the majority of previous studies, although different parameters were adopted. LDL‐C can cause endothelial dysfunction of the penile artery and induce erectile dysfunction in mice . The accumulation of sub‐endothelial lipids, especially low‐density lipoproteins, plays an important role in initiating endothelial dysfunction and atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

Significance of blood lipid parameters as effective markers for arteriogenic erectile dysfunction

Zhang

et al. 2020

Andrology

View full text Add to dashboard Cite

Objectives The aim of the study was to investigate the ability of the blood lipid parameters to predict the discrimination of arteriogenic erectile dysfunction (ED). Materials and methods 260 subjects with ED and 60 healthy controls were enrolled. Eight lipid parameters, including total cholesterol (TC), triglycerides (TG), LDL‐C, HDL‐C, non‐HDL‐C, TC/HDL ratio, TG/HDL ratio, and LDL/HDL ratio, together with other plasma biomarkers like sex hormones were measured in all participants. Nocturnal penile tumescence (NPT), penile color Doppler ultrasonography (pDUS), and neurophysiological tests were conducted in the ED group. Results Forty‐four ED patients with normal NPT, and 84 with normal vasculature or mixed vascular abnormalities were excluded. The remaining 132 men were classified into two groups, arteriogenic ED (n = 87) and venous leakage (n = 45), by pDUS. TC/HDL, LDL/HDL, and LDL‐C were significantly higher (P < .05) and HDL‐C was significantly lower (P < .05) in the arteriogenic ED group when compared with the venous and the control groups. Receiver operating characteristic curve analysis identified area under the curve values that were predictive of arteriogenic ED for: TC/HDL and LDL/HDL 0.720 and 0.737, TC/HDL ≥ 3.73 and LDL/HDL ≥ 2.01 (sensitivity: 56.3%; specificity: 83.3% vs sensitivity: 55.2%; specificity: 91.7%), HDL‐C (0.791), ≤1.25 mmol/L (sensitivity: 69%; specificity: 81.7%), LDL‐C (0.641), ≥2.41 mmol/L (sensitivity: 55.2%; specificity: 76.7%).In the arteriogenic ED group, a significant inverse correlation was detected between TC/HDL, LDL/HDL, LDL‐C and 10‐minutes peak systolic velocity (PSV) (All P < .01)and a significant positive correlation was recognized between HDL‐C and 10‐minutes PSV(P < .01). Multivariate step wise linear regression indicated lipid parameters of LDL/HDL and HDL‐C were significantly associated with 10‐MinPSV (P < .01). Conclusion These findings suggest the LDL/HDL and HDL‐C might be a powerful indicator to predict and diagnose arteriogenic ED, and lipid‐lowing therapy should be considered for these patients.

show abstract

“…17e19 Hyperlipidemia not only causes damage to the vascular smooth muscle tissue of the penis but it also can induce ED by causing damage to the peripheral cavernous nerve that innervates a penile erection. 19,20 It has been extensively studied that autophagy was shown to regulate lipid droplet degradation directly. 13 In our study, it was found, on the basis of MET, that there was improvement in FPG, HbA1c, and AGEs and that ICA II could regulate lipid metabolism by increasing HDL levels and decreasing LDL, TC, and TG levels in T2DMED rats.…”

Section: Discussionmentioning

confidence: 99%

“…17 It has been shown that downregulation of the NOS and cGMP-phosphodiesterase activities are an important occurrence in the pathogenesis of ED. 20,21 Serum T is the main component of androgen and plays a key role in maintaining male sexual function. 22 E2 can resist androgen action in vivo.…”

Section: Discussionmentioning

confidence: 99%

Effect of Icariside II and Metformin on Penile Erectile Function, Histological Structure, Mitochondrial Autophagy, Glucose-Lipid Metabolism, Angiotensin II and Sex Hormone in Type 2 Diabetic Rats With Erectile Dysfunction

Zhang

et al. 2020

Sexual Medicine

View full text Add to dashboard Cite

Introduction: Type 2 diabetes mellitus erectile dysfunction (T2DMED) is one of the common complications of type 2 diabetes mellitus (T2DM). Icariside II (ICA II), a flavonoid derived from Epimedium, has been shown to improve erectile function in T2DMED rats. Aim: To investigate the effect of ICA II and metformin (MET) on penile erectile function, mitochondrial autophagy, glucose-lipid metabolism in rats with T2DMED. Methods: In the control and T2DMED groups, rats were administered normal saline. In the MET group, rats were administered MET for 0.2 g/kg/day. In the ICA IIþMET group, rats were administered ICA II for 10 mg/kg/day and MET for 0.2 g/kg/day. Results: The number of mating rats, number of erectile rats, erection rate, erection frequency, intracorneal pressure, and intracorneal pressure/mean arterial pressure in the ICA IIþMET group and control group were significantly higher than corresponding values in than T2DMED group. The absolute values of fasting plasma glucose, glycated haemoglobin in the ICA IIþMET group, MET group, and control group were significantly lower than in the T2DMED group. The advanced glycation end product (AGE) values in the ICA IIþMET group and the MET group were lower than in the T2DMED group. The receptors for the AGE values and angiotensin II values in the ICA IIþMET group were lower than in the T2DMED and MET groups. The highdensity lipoprotein values, testosterone values, nitric oxide synthase activity, and cyclic guanosine monophosphate content in the ICA IIþMET and control groups were higher than in the T2DMED group. The lowdensity lipoprotein values, triglyceride values, estradiol values, and total cholesterol values in the ICA IIþMET and control groups were lower than in the T2DMED group. Conclusion: ICA II could increase erectile function and smooth muscle cell/collagen fibril proportions, decreased mitochondrial autophagy, and AGE concentrations and improve lipid metabolism, nitric oxide synthase activity, cyclic guanosine monophosphate content, testosterone, estradiol, and Ang II in rat with T2DMED. Zhang J, Li S, Zhang S, et al.

show abstract

Time-course changes of nLDL-induced erectile dysfunction

Cited by 5 publications

References 26 publications

Prevalence and associated factors of erectile dysfunction in men with type 2 diabetes mellitus in eastern Sudan

Prevalence and associated factors of erectile dysfunction in men with type 2 diabetes mellitus in eastern Sudan

Significance of blood lipid parameters as effective markers for arteriogenic erectile dysfunction

Effect of Icariside II and Metformin on Penile Erectile Function, Histological Structure, Mitochondrial Autophagy, Glucose-Lipid Metabolism, Angiotensin II and Sex Hormone in Type 2 Diabetic Rats With Erectile Dysfunction

Contact Info

Product

Resources

About