Time-Course Evaluation of Oxidative Stress-Related Biomarkers after Renal Transplantation

Abstract

Patients with chronic renal disease have a high prevalence of oxidative stress (OS), which is associated with the cardiovascular complications occurring in this population. The restoration of kidney function after kidney transplantation (KT) can lead to reduction in the metabolic abnormalities and elimination of the OS. Time-dependent changes in OS-related markers and specific kidney function and metabolic parameters were evaluated in patients (N = 39; 23 males; 16 females; mean age = 57 ± 10 years) before (day 0) and after KT (day 1, 7, 30, 90, and 180) to monitor the graft. In particular, total antioxidant capacity (TAC), levels of advanced oxidation protein products (AOPP), lipid peroxidation as thiobarbituric acid-reactive substances (TBARS) and reduced glutathione (GSH); activities of glutathione peroxidase, catalase, and superoxide dismutase; and kidney function markers were measured. AOPP, TAC, and TBARS were significantly decreased, whereas GSH was significantly increased after KT. Antioxidant enzyme activities were not significantly changed during the monitored period after KT. Apropos specific kidney function markers and glomerular filtration significantly increased and creatinine level significantly decreased after transplantation. Changes in high-density lipoprotein cholesterol were also found. Our results show that successful KT results in normalization of the antioxidant status and lipid metabolism that is connected with both improved renal function and reduced cardiovascular complications.

Oxidative stress is associated with weight gain in recipients at 12-months following kidney transplantation

“…Our findings are congruent with other studies which reported decreased TAOC at 12 days [20], 6 months [21] and 12 months [22] after kidney transplantation. However, the mechanism which induced decreased TAOC is controversial.…”

“…It was suggested that it might be caused by the reduction of uric acid which may lead to major variations of the internal redox state [20]. Meanwhile, it was also suggested that TAOC may not be related or insufficiently sensitive to oxidative stress after kidney transplantation [21, 22]. Immunosuppressant is considered to be an important factor for the change of TAOC, however, the effect of immunosuppressant is also controversial.…”

Potential role of tacrolimus in erythrocytes’ antioxidative capacity in long-term period after renal transplantation

“…Although, oxidative injury appears to decrease in the first week after Tx, it stays elevated in later post-transplantation period in comparison to healthy individuals (Vostálová et al, 2012) and may result from the end stage renal disease (ESRD)-associated oxidative stress, immune response to allograft, ischemia reperfusion http://dx.doi.org/10.1016/j.ejps.2015.01.013 0928-0987/Ó 2015 Elsevier B.V. All rights reserved. injury, opportunistic infections, and immunosuppressive therapy (Campise et al, 2003;Naesens et al, 2009).…”

Serum Thiol/Disulfide Homeostasis in Hemodialysis, Peritoneal Dialysis, and Renal Transplantation Patients

“…Oxidative stress is supposed to be associated with the pathophysiology of cardiovascular complications of ESRD. Restoration of kidney function after kidney transplantation has been shown to mitigate oxidative stress (7).…”